Comparative efficacy of Keishi-bukuryo-gan and Pentoxifylline on RBC deformability in patients with “oketsu” syndrome

Hikiami, Hiroaki; Goto, Hirozo; Sekiya, Nobuyasu; Hattori, Naoko; Sakakibara, Iwao; Shimada, Yutaka; Terasawa, Katsutoshi

doi:10.1078/094471103322331395

Cited by 36 publications

(33 citation statements)

References 11 publications

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“…Keishibukuryogan is reported to improve the microcirculation of the bulbar conjunctiva, 9) to protect vasofunction in a model of diabetic rat, 10) to decrease atherosclerosis in a model of hypercholesterolemic rabbit, 11) and so on. Concerning the mechanisms of these vasoprotective effects, keishibukuryogan is reported to exert an improvement effect on hemorheological factors 9,12) as well as an anti-oxidant effect. 13) As part of this formula, Cinnamomi Cortex is thought to have various effects on anti-platelet aggregation, 5,6) inhibition of thromboxane A2, 14) to have a vasorelaxation effect, 7) and so on.…”

Section: Discussionmentioning

confidence: 99%

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Yanaga

Goto

Nakagawa

et al. 2006

Biological & Pharmaceutical Bulletin

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Animals Male Wistar rats weighing 370-420 g were purchased from Japan SLC (Shizuoka, Japan). They were kept in an animal room at an ambient temperature of 23Ϯ1°C under a 12-h dark-light cycle. Experimental protocols met the "Guidelines for Animal Experimentation" approved by the Japanese Association of Laboratory Animal Science and the Japanese Pharmacological Society.Preparation of Rat Aorta Rats were anesthetized (50 mg/kg i.p. pentobarbital) and sacrificed by cutting their abdominal aorta. Fats and connective tissues were removed from a section of the thoracic aorta, and 3-mm-wide aortic rings were prepared. For an endothelium-free aorta, the endothelial lining of each ring was removed by pressing the ring and rolling it gently onto a filter paper a few times. The endothelium was considered to be intact when relaxation induced by 1 mM of acetylcholine was over 20% of the maximal tension obtained by 60 mM KCl-induced contraction, and the removal of the endothelium was confirmed by the absence of acetylcholine-induced relaxation.Vasodilative Effect of Cinnamaldehyde on Isolated Aortic Rings The aortic rings were mounted on steel hooks in a Magnus chamber (Kishimoto UC-5TD, Kyoto, Japan). One end of the aorta was attached to a force-displacement transducer (Kishimoto UM-203) so that its isometric contraction could be recorded (NEC RECTI-HORIZ-8K, Tokyo, Japan). The baths were filled with 5 ml of Krebs solution containing the following (mM): NaCl 120, KCl 4.7, NaHCO 3 25.0, KH 2 PO 4 1.2, MgSO 4 · 7H 2 O 1.2, CaCl 2 2.5, and glucose 10.0. The solution was maintained at 37°C and bubbled continuously with 5% CO 2 in O 2 at pH 7.4. The rings were equilibrated for 45 min at an initial resting tension of 1 g. During this period, the Krebs solution in the bath was

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Section: Discussionmentioning

confidence: 99%

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Yanaga

Goto

Nakagawa

et al. 2006

Biological & Pharmaceutical Bulletin

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“…One of the causes of Oketsu is insufficiency of microcirculation in modern medicine. 23) Keishibukuryogan has been reported to improve blood circulation and vasoendothelial disorders in animal models of diabetes and hypertension. 5,6,24,25) The mechanism for this improvement by keishibukuryogan was an anti-oxidative effect on microcirculation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Keishibukuryogan on Vascular Function in Adjuvant-Induced Arthritis Rats

Nozaki

Goto

Nakagawa

et al. 2007

Biological & Pharmaceutical Bulletin

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“…The impacts of keishibukuryogan on the laboratory parameters of coagulation system are shown in reports on shortened PT in disseminated intravascular coagulation (DIC) model rats, 26) shortened PT in patients taking warfarin, 27) and increased D-dimer in patients having received knee replacement surgery. 20) On the other hand, reports on blood coagulation factors in patients receiving keishibukuryogan described decreased fibrinogen in patients with lacunar infarct, 18) improved reduction of thrombotest results and AT-III activity in rats with high blood viscosity, 28) improved reduction of fibrinogen and platelet in DIC model rats. 26) These reports will lead to an assumption that the effects of keishibukuryogan on the coagulation system vary according to the conditions, and these effects will help correct an unbalanced status by exerting impacts both on coagulation and fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

“…The studies on the effect of keishibukuryogan for sensory disturbance include that on arteriosclerosis obliterans of lower extremities reported by Yokokawa, et al 9) and that in patients with cerebral stroke reported by Fujita, et al 10) The authors of the both studies estimated that keishibukuryogan with its effects to promote blood fluidity and peripheral blood flow contributed to the alleviation of the subjective symptoms of the patients by improving coldness and numbness. Various effects of keishibukuryogan have so far been reported: decrease in blood viscosity, 11) dilation of arteries, 11) inhibition of platelet aggregation, 12,13) and promotion of erythrocyte deformability 14) in the field of basic pharmacology, and increase in blood flow rate, 15) decrease in blood viscosity, [15][16][17] inhibition of platelet aggregation, 17) inhibition of erythrocyte aggregation, 15) promotion of erythrocyte deformability, 18) and decrease in hematocrit level 15) in the field of clinical pharmacology. These factors may contribute to the effect of keishibukuryogan to increase peripheral blood flow.…”

Section: Skin Perfusion Pressure (Spp)mentioning

confidence: 99%

Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity

Hayashi¹,

Shibutani²,

Okubo³

et al. 2014

Annals of Vascular Diseases

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The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (*English translation of Jpn J Phlebol 2013; 24: 303-310)

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Comparative efficacy of Keishi-bukuryo-gan and Pentoxifylline on RBC deformability in patients with “oketsu” syndrome

Cited by 36 publications

References 11 publications

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Effects of Keishibukuryogan on Vascular Function in Adjuvant-Induced Arthritis Rats

Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity

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