Comparative efficacy of metaphylaxis with tulathromycin and pentavalent modified-live virus vaccination in high-risk, newly received feedlot cattle

Munoz, Veronica I; Samuelson, Kendall L; Tomczak, Dexter J; Seiver, Hannah A; Smock, Taylor M

doi:10.15232/aas.2020-02054

Cited by 14 publications

(18 citation statements)

References 3 publications

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“…Rectal temperature did not differ ( P > 0.53) among groups during any therapeutic treatment which is consistent with previously published literature ( Godinho et al, 2005 ; Munoz et al, 2020 ). Nonetheless, Catry et al (2008) reported rectal temperature was greater for calves given florfenicol than calves given no metaphylaxis.…”

Section: Resultssupporting

confidence: 92%

“…Our findings are supported by studies comparing tulathromycin and ceftiofur as metaphylaxis to a negative control that reported no difference in final BW ( Godinho et al, 2005 ; Benton et al, 2008 ). In contrast, others have reported increased final BW during the receiving period when metaphylaxis is given ( Catry et al, 2008 ; Munoz et al, 2020 ). The inconsistency of results could be explained by a different length of time in the receiving period [20 d in the Catry et al (2008) study, and 56 d in the Munoz et al (2020) study, compared to 38–45 d in the present study].…”

Section: Resultsmentioning

confidence: 87%

“…In contrast, others have reported increased final BW during the receiving period when metaphylaxis is given ( Catry et al, 2008 ; Munoz et al, 2020 ). The inconsistency of results could be explained by a different length of time in the receiving period [20 d in the Catry et al (2008) study, and 56 d in the Munoz et al (2020) study, compared to 38–45 d in the present study].…”

Section: Resultsmentioning

confidence: 87%

“…Metaphylaxis is the administration of long-acting antibiotics at arrival to cattle that may not have a chance to develop an appropriate immune response to control BRD ( Urban-Chmiel and Grooms, 2012 ; Abell et al, 2017 ). Munoz et al (2020) reported a decreased percentage of calves required treatment for BRD when given metaphylaxis (18.5% vs. 51.2%). Many commercially available metaphylactic antimicrobials act with differing efficacies, making the selection of medications challenging for commercial producers.…”

Section: Introductionmentioning

confidence: 98%

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The effects of administering different metaphylactic antimicrobials on growth performance and health outcomes of high-risk, newly received feedlot steers

Coppin

Smock

Helmuth

et al. 2022

Translational Animal Science

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Bovine respiratory disease is the primary animal health concern facing feedlot producers. Many antimicrobial mitigation strategies are available, but few studies have compared feedlot performance during both the receiving and finishing periods following application of different antimicrobials used as metaphylaxis at arrival. The objective of this study was to compare antimicrobial metaphylaxis methods on clinical health and growth performance across both the receiving and finishing periods. A total of 238 multiple-sourced steers in 2 source blocks were used in a generalized complete block design. The 4 treatments included: 1) a negative control, 5 mL of sterile saline injected subcutaneously (CON); 2) subcutaneous administration of florfenicol at 40 mg/kg of BW (NUF); 3) subcutaneous administration of ceftiofur in the posterior aspect of the ear at 6.6 mg/kg of BW (EXC); and 4) subcutaneous administration of tulathromycin at 2.5 mg/kg of BW (DRA). The morbidity rate for the first treatment of BRD was decreased for the DRA and EXC treatments compared to CON and NUF (P < 0.01). Additionally, average daily gain (ADG), dry matter intake (DMI), and gain-to-feed (G:F) were greater (P ≤ 0.02) in the DRA treatment during the receiving period compared to all other treatments. The ADG was also greater (P < 0.05) for EXC than the CON treatment throughout the finishing period. Nonetheless, other growth performance variables did not differ among metaphylactic treatments during the finishing period (P ≥ 0.14). Likewise, no differences in carcass characteristics or liver abscess score were observed (P ≥ 0.18). All complete blood count (CBC) variables were affected by day (P ≤0.01) except mean corpuscular hemoglobin concentration (P = 0.29). Treatment ×time interactions were observed for platelet count, white blood cell (WBC) count, monocyte count and percentage, and lymphocyte percentage (P ≤0.03). However, there were no observed hematological variables that differed among treatment (P ≥0.10). The results indicate that some commercially available antimicrobials labeled for metaphylactic use are more efficacious than others in decreasing morbidity rate.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

The effects of administering different metaphylactic antimicrobials on growth performance and health outcomes of high-risk, newly received feedlot steers

Coppin

Smock

Helmuth

et al. 2022

Translational Animal Science

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“…Treatments did not differ in BW and ADG throughout the 42-d study, but the percentage of calves treated once (28.4 vs. 53.4) or twice (4.6 vs. 28.4) for BRD was less with tulathromycin than with tilmicosin. The interaction of metphylaxis with tulathromycin and vaccination with a pentavalent modified-live virus respiratory vaccine was evaluated by Munoz et al (2020) using 478 bull and steer calves (234 kg) sourced from auction markets. The metaphylaxis × vaccination interaction was not significant for BRD morbidity or performance variables.…”

Section: Introductionmentioning

confidence: 99%

Galyean Appreciation Club Review: revisiting nutrition and health of newly received cattle—what have we learned in the last 15 years?

Galyean

Duff

Rivera

2022

Journal of Animal Science

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Our objective was to review the literature related to the health and management of newly received cattle published since a previous review by Duff and Galyean (2007). Bovine respiratory disease (BRD) continues to be a major challenge for the beef industry. Depending on disease severity, animals treated for BRD have decreased performance and lowered carcass value. Diagnosis of BRD is less effective than desired, and progress on developing real-time, chute-side methods to diagnose BRD has been limited. Systems that combine lung auscultation with temperature and BW data show promise. Assessment of blood metabolites and behavior monitoring offer potential for early identification of morbid animals. Vaccination and metaphylaxis continue to be important tools for prevention and control of BRD, but antimicrobial resistance is a concern with antibiotic use. Dietary energy concentration and roughage source/level continue to be important topics. Mineral supplementation has received considerable attention, particularly the use of organic vs. inorganic sources and injectable minerals or drenches given on arrival. Use of probiotics and prebiotics for newly received cattle has shown variable results, but further research is warranted. Health and nutrition of newly received cattle will continue to be an important research area in the years to come.

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Impacts of including Sweet Bran and wet distillers grains with solubles alone or in combination in finishing cattle diets on physically effective fiber concentrations and rumen buffering characteristics of feedlot cattle

Spowart

Richeson

Crawford

et al. 2022

Translational Animal Science

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This study evaluated the effects of Sweet Bran (SB) and wet distillers grains with solubles (WDGS) in the diet alone or in combination on physically effective NDF (peNDF), ruminal pH, and rumination behavior of finishing beef cattle. For this study, 455 steers (373 ± 15.5 kg) were allocated to 48 pens in a randomized complete block design. Treatments (n = 12 pens per treatment) were 1 of 4 steam-flaked corn-based diets containing no corn-milling products (CON), 20% WDGS (WDGS20), 20% SB (SB20), or 20% SB and 10% WDGS (COMBO). Within each pen, 2 steers were randomly selected to receive an indwelling ruminal pH bolus to quantify ruminal pH and a 3-axis accelerometer tag to measure rumination for the first 92 d of the study. Diet samples were collected weekly to determine particle size, neutral detergent fiber (NDF) concentration, and peNDF. Physically effective NDF was calculated using both the proportion of particles > 4.0 mm (peNDF4.0) and the proportion of particles > 8.0 mm (peNDF8.0). The percentage of particles > 4.0 mm was greatest (P < 0.01) for CON, intermediate for SB20, and least for WDGS20 and COMBO. Both NDF (P < 0.01) and peNDF4.0 (P < 0.01) were greatest for COMBO, intermediate for WDGS20 and SB20, and least for CON. The percentage of particles > 8.0 was greatest (P < 0.01) for CON, intermediate for WDGS20 and SB20, and least for COMBO, but peNDF8.0 did not differ (P = 0.40). A diet × day interaction (P < 0.01) was observed for daily rumination minutes per kg of DMI, NDF, peNDF8.0, and peNDF4.0. A diet × hour interaction (P < 0.01) was observed where CON cattle spent less time ruminating at 0800 and 1000 h in a 24 h period. Daily ruminal pH was greatest (P < 0.01) for COMBO, intermediate for SB20 and WDGS20, and least for CON. A diet × hour interaction (P < 0.01) was also observed for circadian ruminal pH, where pH was least for CON from 0800 to 1800 h. Relationships between peNDF, rumination behavior, and ruminal pH observed in this study suggest that SB and WDGS similarly enhance rumen buffering capacity when steam-flaked corn is replaced in the diet.

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Comparative efficacy of metaphylaxis with tulathromycin and pentavalent modified-live virus vaccination in high-risk, newly received feedlot cattle

Cited by 14 publications

References 3 publications

The effects of administering different metaphylactic antimicrobials on growth performance and health outcomes of high-risk, newly received feedlot steers

The effects of administering different metaphylactic antimicrobials on growth performance and health outcomes of high-risk, newly received feedlot steers

Galyean Appreciation Club Review: revisiting nutrition and health of newly received cattle—what have we learned in the last 15 years?

Impacts of including Sweet Bran and wet distillers grains with solubles alone or in combination in finishing cattle diets on physically effective fiber concentrations and rumen buffering characteristics of feedlot cattle

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