Comparative efficacy of topical hemostatic agents in a rat kidney model

Raccuia, Joseph S.; Simonian, Gregory; Dardik, Michael; Hallac, David; Raccuia, Salvatore V.; Stahl, Rosalyn; Dardik, Herbert

doi:10.1016/0002-9610(92)90108-4

Cited by 43 publications

(37 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Bleeding from experimental liver injuries in animal models has been reported to be effectively controlled with collagen-based hemostatic agents. 13,15,21,22,25 Laboratory investigations confirm that these collagenbased agents trigger platelet aggregation when directly applied to bleeding tissue. 26,27 Bovine thrombin likewise has inherent hemostatic properties via the conversion of fibrinogen to fibrin.…”

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

Effective Control of Hepatic Bleeding With a Novel Collagen-Based Composite Combined With Autologous Plasma

Chapman¹

2000

Arch Surg

110

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 99%

“…6,[10][11][12] Topical hemostatic agents also have been used with varying degrees of success in this setting. These agents include oxidized regenerated cellulose, 13 …”

Section: See Invited Critique At End Of Articlementioning

confidence: 99%

Effective Control of Hepatic Bleeding With a Novel Collagen-Based Composite Combined With Autologous Plasma

Chapman¹

2000

Arch Surg

110

View full text Add to dashboard Cite

“…Results from animal studies show improved haemostatic performance of fibrin sealants compared with conventional topical haemostats [17, 18]. In a clinical study of haemostasis during arteriovenous polytetrafluoroethylene graft placement for dialysis, more rapid haemostasis was achieved with a fibrin sealant (derived from pooled plasma and thrombin) than with bovine thrombin-soaked cellulose sponges or Surgicel (mean times to haemostasis were 0.5, 6 and 17 min, respectively) [19].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Haemostatic Effect of Vivostat<sup>®</sup> Patient-Derived Fibrin Sealant with Oxidised Cellulose (Surgicel<sup>®</sup>) in Multiple Surgical Procedures

2003

View full text Add to dashboard Cite

Aim: To evaluate the haemostatic properties of Vivostat^® patient-derived fibrin sealant in a broad range of surgical procedures. Method: In a prospective, randomised, multicentre, clinical study, typical surgical wounds of 69 patients (cardiothoracic, general, obstetric and gynaecologic, and vascular), requiring intervention to control bleeding, were treated with either Vivostat-derived sealant (n = 35) or Surgicel^® (n = 34) as required and the time taken to arrest bleeding was assessed. Results: Compared with Surgicel, the mean time to haemostasis of Vivostat-derived sealant was significantly shorter (1.6 vs. 3.3 min, p < 0.0001) and more patients were successfully treated (i.e. no additional haemostatic measures required; 94 vs. 65%, p = 0.003). Conclusion: Vivostat-derived sealant is a more reliable and rapidly effective surgical haemostat than Surgicel.

show abstract

“…Advantages of collagen fleece are fast induction of hemostasis, low S90 tissue reaction, and fast resorption [4] .Another significant advantage is that excess collagen can be carefully teased away from around the hemorrhage site without re-initiating bleeding. A major disadvantage of using the collagen fleece is difficulty in manipulating the agent during attempts to place it in the area of bleeding [34]. ORC is a chemically altered form of cellulose [26,33,48,49].…”

Section: Chemical Propertiesmentioning

confidence: 99%

“…The collagen materials, though effective, required a longer time to control bleeding and did not differ from one another statistically in their activity. Microfibrillar collagen was showed to be the best overall hemostatic agent in microvascular surgery [34].…”

Section: Animal Studiesmentioning

confidence: 99%