Effective Control of Hepatic Bleeding With a Novel Collagen-Based Composite Combined With Autologous Plasma

Chapman, William C.

doi:10.1001/archsurg.135.10.1200

Cited by 110 publications

(94 citation statements)

References 23 publications

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“…This vascularization exists with sinusoidal formation that does not contain smooth muscle fi bres, which would provide vasoconstriction. Therefore, uncontrollable severe bleedings occur when tissue integration is impaired in any way (3).…”

Section: Introductionmentioning

confidence: 99%

“…One of these methods is the use of topical hemostatic agents. For this purpose, studies have been performed with oxidized cellulose compounds, gelatin sponge with or without thrombin, microfi ber collagens, and fi brin glue (3). Ca 2+ Alginate cover (Sorbalgon, Hartmann) is a topical hemostatic agent, which acts by releasing Ca ion and provides clotting.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Ankaferd Blood Stopper and calcium alginate in experimental model of hepatic parenchymal bleeding

Aydin¹,

Tuncal²,

Kilicoglu³

et al. 2015

BLL

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:Background:This experimental study compared the hemostatic effects of calcium alginate and Ankaferd Blood Stopper in hepatic parenchymal bleedings. Material and method:The study comprised 39 male Wistar albino rats (weight 230±30 g). Laceration model was created in the left lateral lobe of the liver. Standard cotton gauze that was impregnated 0.9% NaCl solution and Calcium alginate cover was compared to ABS tampon. The amount of preoperative bleeding, preoperative and postoperative Day 1 hematocrit levels, and the difference between them were assessed and statistically analyzed. Results: Comparing the hematocrit levels between the groups, we found that the amount of bleeding was signifi cantly higher in the control group versus the study groups (p<0.001). Histopathological examination revealed the portal area enlargement and biliary canaliculi proliferation. In the Ca 2+ Alginate group, it was observed that the fi bres were still present in the incision line with massive fi brotic area around. In the Ankaferd group, examination of the preparations revealed patchy focal necrosis areas but no fi brotic area. Conclusion:With this study, we demonstrated that both calcium alginate and Ankaferd have hemostatic effect in preventing hepatic parenchymal bleeding and that calcium alginate causes fi brosis in the liver, where ABS causes focal necrosis areas (Tab. 2, Fig. 4, Ref. 19). Text in PDF www.elis.sk.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Ankaferd Blood Stopper and calcium alginate in experimental model of hepatic parenchymal bleeding

Aydin¹,

Tuncal²,

Kilicoglu³

et al. 2015

BLL

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show abstract

“…The time for clotting is around 2-3 min when compared to other published similar hemostats which are in the range 3-10 min [21][22][23][24][25][26][27]. This is due to high porosity because of fi brous nature and easy release or accessibility of throm- bin for clotting phenomenon.…”

Section: Resultsmentioning

confidence: 94%

Rapid purification of high purity thrombin and preparation of a novel hemostat for clinical purposes

Turaga

Rao

Sripad

2008

Indian J Hematol Blood Transfus

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Thrombin was prepared from crude prothrombin enriched plasma by activation using Russell's viper venom. Prothrombin was prepared by barium sulphate adsorption and elution of prothrombin enriched fraction using high concentrations of sodium citrate. This fraction was directly activated with venom and thrombin was purifi ed by SP Sepharose ion-exchange chromatography and subsequently over Phenyl-sepharose column. This product exhibits a purity of >98% with an activity of at least 6000U/ mg or higher. The Thrombin was further used in the preparation of a novel bio-absorbable hemostat using Calcium Alginate fi ber sheet which acts as an absorbable hemostat. The present hemostat is highly porous, easy to use and has faster clotting time due to higher solubility of calcium fi bers and thereby releasing thrombin.

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“…Karaciğer ve dalak cerrahisinde kullanımının kanama kontrolündeki etkisi gösteril-miştir. [9][10][11][12][13] Ankaferd Blood Stopper ® (ABS) son yıllarda klinik kullanıma giren, bitkisel kökenli, topikal hemostatik ajandır. Hemostazı, kanama pıhtılaşma faktörle-rinden bağımsız olarak, enkapsüle protein ağı ile fokal eritrosit agregasyonunu sağlayarak gerçekleştirir.…”

Section: Resultsunclassified

“…Ameliyat süresinin kısalması için, kanamanın kontrolünde topikal hemostatiklerin kullanımı da cerraha avantaj sağlayabilir Günümüz-de Japonya'da topikal hemostatiklerin karaciğer cerrahisinde standart bir endikasyon olmadan kullanımı %60'a kadar çıkmıştır. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Bu ajanların seçiminde cerrahın tercihi kadar, hemostatik materyalin yapısı, kanamanın ciddiyeti, acil ya da elektif cerrahi yaklaşımlar gibi faktörler oynar. Fiyat, uygulama kolaylığı ve muhafaza edilme özellikleri de seçimi etkilemektedir.…”

Section: Discussionunclassified

Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats

Akarsu¹,

Kalaycı²,

Yavuz³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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Effective Control of Hepatic Bleeding With a Novel Collagen-Based Composite Combined With Autologous Plasma

Cited by 110 publications

References 23 publications

Effects of Ankaferd Blood Stopper and calcium alginate in experimental model of hepatic parenchymal bleeding

Effects of Ankaferd Blood Stopper and calcium alginate in experimental model of hepatic parenchymal bleeding

Rapid purification of high purity thrombin and preparation of a novel hemostat for clinical purposes

Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats

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