2019
DOI: 10.1111/vop.12634
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Comparative efficacy of topical oclacitinib 0.1% and tacrolimus 0.01% in canine keratoconjunctivitis sicca

Abstract: Objective To assess the efficacy of 0.1% oclacitinib as a single agent, and in combination with tacrolimus 0.01%, for the control of ophthalmic signs of keratoconjunctivitis sicca (KCS) in dogs. Animals studied Thirty‐two dogs (57 eyes) diagnosed with idiopathic KCS were included. Inclusion criteria were Schirmer Tear Test 1 (STT‐1) values <15 mm/min and concurrent clinical signs such as ocular hyperemia and discharge. Procedures The animals were submitted to a randomized, open‐label, 5‐week study and divided … Show more

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Cited by 7 publications
(6 citation statements)
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“…The STT I is performed by placing a standardized 5 mm 9 35 mm strip of Whatman no. 41 filter paper in the ventral conjunctival fornix for 60 seconds, without the use of topical anesthesia . KCS is usually suspected when STT results are below 15 mm/min and are associated with ophthalmic signs, such as hyperemia, mucoid discharge accumulation, and keratitis .…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The STT I is performed by placing a standardized 5 mm 9 35 mm strip of Whatman no. 41 filter paper in the ventral conjunctival fornix for 60 seconds, without the use of topical anesthesia . KCS is usually suspected when STT results are below 15 mm/min and are associated with ophthalmic signs, such as hyperemia, mucoid discharge accumulation, and keratitis .…”
Section: Methodsmentioning
confidence: 99%
“…12 KCS is usually suspected when STT results are below 15 mm/min and are associated with ophthalmic signs, such as hyperemia, mucoid discharge accumulation, and keratitis. 12 Exclusion criterion was preexisting ocular disease. Information retrieved from the medical records were: breed, weight, sex, tumor histology, modified Adams stage retrospectively;…”
Section: Introductionmentioning
confidence: 99%
“…However, these more subtle features are not always apparent to owners, thus dogs typically present with more advanced stages of disease with severe clinical signs, including hyperemia, mucopurulent discharge, and secondary corneal disease, such as fibrosis, neovascularization, and pigmentation (Figure 2). 46,47 …”
Section: Clinical Presentationmentioning
confidence: 99%
“…Topical 0.1% oclacitinib has been used to treat canine keratoconjunctivitis sicca (KCS), and its efficacy has been compared to that of 0.1% topical tacrolimus. 56 Topical 0.1% oclacitinib twice daily was not effective in controlling the ocular signs of KCS in dogs, and its use is not justified.…”
Section: Use For Nonallergic/ Atopic Disease Autoimmune/immune-mediat...mentioning
confidence: 99%