Comparative evaluation of coenzyme Q₁₀-based gel and 0.8% hyaluronic acid gel in treatment of chronic periodontitis

Abstract

Background:The anti-inflammatory and immune enhancing effects of coenzyme Q10 (CoQ10) and hyaluronic acid are well established in medical literature. The present study was undertaken to evaluate their role in chronic periodontitis.Materials and Methods:One hundred twenty sites in 24 patients with clinically confirmed periodontitis were included in the study. A split-mouth design was used for intrasulcular application of CoQ10 as adjunct to scaling and root planing (SRP), 0.8% hyaluronic acid as adjunct to SRP and SRP alone. Clinical parameters such as plaque index (PI), gingival color change index (GCCI), Eastman interdental bleeding index (EIBI), pocket depth (PD), and clinical attachment level (CAL) were recorded. All the clinical parameters PI, EIBI, GCCI, PD, and CAL were recorded at baseline before SRP. Only PI, EIBI, and GCCI were recorded at 1st and 2nd week. Twenty-one days post 2nd week, i.e., 6th week all the clinical parameters were recorded again.Results:Intragroup analysis of all the clinical parameters showed clinical significant results between baseline and 6th week. However, on intergroup analysis, the results were not significant.Conclusion:The local application of CoQ10 and hyaluronic acid gel in conjunction with SRP may have a beneficial effect on periodontal health in patients with chronic periodontitis.

Subgingivally delivered coenzyme Q10 in the treatment of chronic periodontitis among smokers: A randomized, controlled clinical study

“…The reduction in plaque scores could be attributed to the proper oral hygiene maintenance after SRP. These results are consistent with the clinical study conducted by Sharma et al 22 who found that there was no difference in plaque index scores in sites receiving coenzyme-Q10. This suggests that co-enzyme Q10 might not have any additional benefit in reducing plaque formation.…”

Evaluation of Efficacy of Coenzyme Q10 as an Adjunct to Nonsurgical Periodontal Therapy and Its Effect on Crevicular Superoxide Dismutase in Patients with Chronic Periodontitis

“…In similar studies by Sharma et al (2016), 13 Attia et al (2016), 14 and Roopa et al (2014), 15 it was found that there were some clinical changes in the group treated with CoQ10, but it was not statistically significant than the control group. The clinical change could be due to immune enhancing property of CoQ10, but it was not statistically significant due to the fact that effect of CoQ10 locally may not be enough to provide a significant change than SRP.…”

“…10 Antioxidant therapy for treatment of periodontitis has given positive results as stated in a systemic review by Castro et al 11 CoQ10, which is also known as ubiquinone, because of its ubiquitous presence, is an antioxidant enzyme and has been studied widely for its effect in treatment of periodontal disease. [12][13][14][15][16][17][18][19][20] In the present study, an attempt had been made to evaluate the efficacy of CoQ10 in reduction of clinical parameters (GI, PI, PPD, and CAL) and its effect on SOD in GCF as an adjunct to Phase 1 periodontal therapy.…”

“… 10 Antioxidant therapy for treatment of periodontitis has given positive results as stated in a systemic review by Castro et al 11 CoQ10, which is also known as ubiquinone, because of its ubiquitous presence, is an antioxidant enzyme and has been studied widely for its effect in treatment of periodontal disease. 12 13 14 15 16 17 18 19 20 …”

“…Previous studies conducted with CoQ10 by various authors 12 13 14 15 16 17 18 19 20 did not use any biochemical parameter to assess its efficacy and the results were assessed by the clinical parameters alone.…”