Comparative Evaluation of Cranial Base and Facial Morphology of Cleft Lip and Palate Patients With Normal Individuals in Cone Beam Computed Tomography

Jahanbin, Arezoo; Eslami, Neda; Zarch, Hosein Hoseini; Kobravi, Sepehr

doi:10.1097/scs.0000000000001361

Cited by 16 publications

(27 citation statements)

References 12 publications

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“…Furthermore, slight but non-significant increase was detected in vertical skeletal dimensions in cleft individuals. Hence when these data are evaluated coherently with the literature that point out similar mandibular morphologies between cleft and NC individuals ( 26 , 27 , 28 ) but report significantly lower sagittal parameters for cleft patients ( 29 , 30 , 31 ), backwards rotation of the mandible with retrognathic sagittal position ( 19 , 32 , 33 ) appears to be responsible for the deficient projection values. Likewise, although statistically significant correlations between SNB and projection values of LLA and B’ were detected, the correlation coefficients were relatively weak hence it will not be possible to make precise predictions concerning Arnett and Gunson soft tissue parameters based on skeletal parameters.…”

Section: Discussionsupporting

confidence: 78%

Evaluation of Mandibular Hard and Soft Tissues in Cleft Patients

Aras¹,

Baykal²,

Bulut³

et al. 2017

J Istanbul Univ Fac Dent

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Purpose:The aim of this study was to compare the mandibular hard and soft tissue measurements of unilateral and bilateral cleft lip and palate patients with non-cleft individuals.Materials and Methods:The study sample comprised of lateral cephalograms of 45 subjects. Sample included 15 non-cleft (NC), 15 unilateral cleft lip and palate (UCLP) and 15 bilateral cleft lip and palate (BCLP) cases whose age were between 15 to 17. 1 angular 13 linear measurements were carried out using Arnett and Gunson soft tissue cephalometric analysis and 4 angular measurements were calculated with Steiner Analysis.Results:Mandibular incisor inclinations relative to the occlusal plane (Md1-Md OP) were significantly greater and mandibular incisor projections (Md1-TVL) were significantly retrusive in cleft subjects (p<0.05). Projection values pertaining to lower lip anterior (LLA-TVL), soft tissue B point (B’-TVL), and soft tissue pogonion (Pog’-TVL) were significantly deficient as well in cleft patients (p<0.05). Sagittal position of the maxilla (SNA) (p<0.001) and intermaxillary relation of the jaws (ANB) were significantly deficient in UCLP subjects (p<0.05) and BCLP individuals (p<0.01). LLA-TVL and B’-TVL correlated with SNB in cleft patients (p<0.05).Conclusion:Decreased lower lip and chin projection values suggest that mandibular region of cleft patients should be taken into account in forming the treatment plan to improve the esthetic outcome of orthodontic and plastic surgery interventions.

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Section: Discussionsupporting

confidence: 78%

Evaluation of Mandibular Hard and Soft Tissues in Cleft Patients

Aras¹,

Baykal²,

Bulut³

et al. 2017

J Istanbul Univ Fac Dent

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“…A maioria dos estudos feitos anteriormente comparando as medidas cefalométricas da base de crânio de pacientes portadores de fissura labiopalatal utilizou-se de métodos bidimensionais (2D) (Brader, 1957;Moss, 1956;Blaine, 1969;Dalh, 1970;Horswell;Gallup,1992;Trotman et al, 1993;Chang et al, 2005;Corbo et al, 2005;Cortés;Granic, 2006;Alkofide, 2008;Chang et al, 2014;Jahanbim et al, 2015;Tinano et al, 2015).…”

Section: Discussionunclassified

“…As anormalidades nas estruturas craniofaciais têm sido apontadas como fatores responsáveis pelo pouco desenvolvimento na área da fissura e também em outras regiões da base do crânio. Muitas pesquisas mostram que se as alterações nas estruturas cranianas são encontradas nesses indivíduos portadores de fissuras labiopalatais, tais anormalidades poderiam influenciar o desenvolvimento do terço médio da face (Moss, 1956;Blaine, 1969;Dalh, 1970;Horswell;Gallup,1992;Trotman et al, 1993;Chang et al, 2005;Cortés;Granic, 2006;Alkofide, 2008), no entanto, outros estudos não encontraram diferenças nas dimensões e forma da base do crânio nesses indivíduos (Brader, 1957;Corbo et al, 2005;Jahanbim et al, 2015;Tinano et al, 2015).…”

Section: Discussionunclassified

“…O único estudo encontrado na literatura que fez análise de imagens em 3D não encontrou diferenças significativas na base de crânio de pacientes portadores de fissura labiopalatais, quando comparados com outros grupos de pacientes que não têm a deformidade facial (Jahanbim et al, 2015), os nossos resultados estão de acordo com este estudo quando se refere à variável ângulo Ba-S-N e a distância S-N, mas a distância Ba-S, revelou ter diferenças estatísticas em relação aos outros dois grupos.…”

Section: Discussionunclassified

“…Um único estudo analisou a base de crânio em imagens 3D. Este, foi realizado em 2015 por Jahanbin et al, não encontrou diferença na base de crânio entre pacientes fissurados e um grupo controle (Jahanbim et al, 2015), o que não está em conformidade com o nosso estudo.…”

Section: Classificação Das Fissuras Labiopalataisunclassified

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Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular

Lima¹

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The aim of this study was to verify the existence of variations of the skull base morphometry between patients with cleft lip and palate, with dentofacial deformity group and without dentofacial deformity (control group). Methodology: Three groups of patients, one group with dentofacial deformity associated without cleft lip and palate (DFSF), another with cleft lip and palate (FS), and another group of patients without cleft and without deformity (CTRL) were included by means of medical records and DICOM (Digital Imaging Communications in Medicine) images of their CT (Computed Tomography) scans. By identifying the basio (Ba), sela (S) and nasio (N) cephalometric points in the Dolphin Imaging 11.9 software, the distance between the points Ba-S (DBaS), S-N(DSN) and the angle formed between points Ba-S-N (AnGBaSN) were the variables. They were statistically evaluated by means of the p> 0.05. Results: Twenty patients were included on each group. We found that the distance S-N (DSN) is not statistically different between the groups, but the Ba-S distance (DBaS) and the Ba-S-N angle (AnGBaSN) are statistically different when compared the three groups. The Ba-S-N angle (AnGBaSN) did not present statistically different when compared to the control group (CTRL) and the group cleft lip and palate patients (FS), but presented statistical difference in relation to the group of patients with facial deformities without cleft lip and palate (DFSF). The distance BaS (DBaS) presented statistical difference between the group of patients with fissures (FS) in relation to the other two groups. Conclusion: Differences in skull base morphometry among patients with dentofacial deformity associated or not with cleft lip and palate suggest that standardized values for cephalometric analyzes involving such structures should be used with caution. New cephalometric patterns, especially by 3D analysis, are desirable to compensate for these anatomical differences.

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MEMO1 drives cranial endochondral ossification and palatogenesis

Otterloo

Feng

Jones

et al. 2016

Developmental Biology

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The cranial base is a component of the neurocranium and has a central role in the structural integration of the face, brain and vertebral column. Consequently, alteration in the shape of the human cranial base has been intimately linked with primate evolution and defective development is associated with numerous human facial abnormalities. Here we describe a novel recessive mutant mouse strain that presented with a domed head and fully penetrant cleft secondary palate coupled with defects in the formation of the underlying cranial base. Mapping and non-complementation studies revealed a specific mutation in Memo1 - a gene originally associated with cell migration. Expression analysis of Memo1 identified robust expression in the perichondrium and periosteum of the developing cranial base, but only modest expression in the palatal shelves. Fittingly, although the palatal shelves failed to elevate in Memo1 mutants, expression changes were modest within the shelves themselves. In contrast, the cranial base, which forms via endochondral ossification had major reductions in the expression of genes responsible for bone formation, notably matrix metalloproteinases and markers of the osteoblast lineage, mirrored by an increase in markers of cartilage and extracellular matrix development. Concomitant with these changes, mutant cranial bases showed an increased zone of hypertrophic chondrocytes accompanied by a reduction in both vascular invasion and mineralization. Finally, neural crest cell-specific deletion of Memo1 caused a failure of anterior cranial base ossification indicating a cell autonomous role for MEMO1 in the development of these neural crest cell derived structures. However, palate formation was largely normal in these conditional mutants, suggesting a non-autonomous role for MEMO1 in palatal closure. Overall, these findings assign a new function to MEMO1 in driving endochondral ossification in the cranium, and also link abnormal development of the cranial base with more widespread effects on craniofacial shape relevant to human craniofacial dysmorphology.

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Comparative Evaluation of Cranial Base and Facial Morphology of Cleft Lip and Palate Patients With Normal Individuals in Cone Beam Computed Tomography

Cited by 16 publications

References 12 publications

Evaluation of Mandibular Hard and Soft Tissues in Cleft Patients

Evaluation of Mandibular Hard and Soft Tissues in Cleft Patients

Comparação da morfometria da base de crânio de indivíduos com fissura labiopalatal e indivíduos com ou sem discrepância maxilo-mandibular

MEMO1 drives cranial endochondral ossification and palatogenesis

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