Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements

Garg, Prachi; Ghalaut, Pankaj; Dahiya, Kiran; Ravi, Reena; Sharma, Anshu; Wakure, Poonam

doi:10.4103/njms.njms_49_20

Cited by 12 publications

(13 citation statements)

References 30 publications

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“…Zhou et al found an increase in osseointegration in osteoporotic rats given Vitamin D supplements (23), while Wu et al found an increase in the percentage of interaction of bone with implant in diabetic rats given Vitamin D supplements (23). According to the findings of this study, vitamin D stimulates osteoblasts and promotes the synthesis of extracellular matrix proteins by osteoblasts (24).…”

Section: Discussionsupporting

confidence: 54%

Impact of Vitamin D3 Supplementation on Dental Implant Stability

Salih¹,

Al-Mashhadane²,

Hamed³

2023

Mil. Med. Sci. Lett.

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Objectives: The goal of this study was to see how systemic vitamin D3 supplementation affected the durability of dental implants as assessed by radiofrequency analysis.Methods: This split-mouth clinical trial included a total of twelve patients seeking dental implant therapy, ranging in age from 25 to 50 years. The patients were divided into control group and treatment group. Each patient in both groups received dental implants in posterior maxillary extraction sites. The radiofrequency analysis (RFA) was conducted using Osstell Mentor device to evaluate the stability of dental implant at various time points.Results: During the three months of the trial, substantial differences between the treatment and control groups were detected according to osstell meter device at the time of insertion (primary stability) and 3 months later (secondary stability).Conclusion: Vitamin D supplementation has a positive effect on dental implant stability.

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Section: Discussionsupporting

confidence: 54%

Impact of Vitamin D3 Supplementation on Dental Implant Stability

Salih¹,

Al-Mashhadane²,

Hamed³

2023

Mil. Med. Sci. Lett.

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“…The articles excluded and the reasons for their exclusion are shown in Table 1 [ 24 , 25 , 26 , 27 , 28 ]. In this review, the study by Mangano et al [ 29 ] was considered a continuation of the study by Mangano et al [ 30 ], so it was treated as a single study for purposes of data extraction.…”

Section: Resultsmentioning

confidence: 99%

Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review

Bazal-Bonelli

Sánchez-Labrador

Brinkmann

et al. 2022

IJERPH

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This systematic literature review set out to investigate the relationship between serum vitamin D levels and dental implants in terms of survival rates, marginal bone loss, and associated complications. The review was conducted according to PRISMA guidelines, performing an electronic search in four databases (Pubmed, Web of Science, Cochrane, and Scopus), complemented by a manual search up to April 2022. Four articles were selected for analysis. The Newcastle-Ottawa Quality Assessment Scale tool was used to assess the quality of evidence of cohort studies, and the Cochrane bias assessment tool was used to assess the quality of evidence of randomized clinical trials. The study included 1089 patients restored with 1984 dental implants, with follow-up periods ranging from 20–240 months. Cases presenting lower serum vitamin D levels obtained slightly worse results in terms of marginal bone loss. Longer follow-up periods are needed in order to determine whether serum vitamin D levels affect implant survival rates and osseointegration over time.

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“…Higher vitamin D levels on the dental implant surgery day were associated with lower marginal bone loss after 6 and 12 months in the RCT from Kwiatek and co-workers [70]. Accordingly, on prospective clinical trial, there was a tendency for less peri-implant bone loss in patients taking vitamin D3 supplements [71]. Despite the limited number of studies, clinical findings support a potential role for supplementation in vitamin D deficient patients subjected to implant-based tooth replacement.…”

Section: Peri-implant Disease and Vitamin Dmentioning

confidence: 86%

The Role Of Vitamin D In Periodontal And Peri-Implant Health

Molayem¹,

Lin²,

Pontes³

2021

JOMDR

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The study of rickets led to the discovery of vitamin D, which is a fat-soluble steroid hormone, whose precursor is converted into active metabolites in the skin when subjects to ultraviolet light. Few foods are rich in vitamin D, with sensible exposure to sunlight being the main natural source for the production of this vitamin. Vitamin D is carried by vitamin D-Binding Protein (DBP) in the circulation and binds to host cells through the Vitamin D Receptor (VDR). Several diseases and conditions have been linked to vitamin D deficiency and insufficiency, including periodontal disease. Vitamin D insufficiency is highly prevalent worldwide. It negatively impacts bone growth and metabolism, and multiple aspects of the immune response, mainly through the regulation of anti-microbial peptides such as Cathelicidin and β-defensins. Low vitamin D levels have been linked to increased gingival inflammation, periodontal destruction, alveolar bone loss, and tooth loss. It can also possibly affect osseointegration, although it has been explored in clinical studies on dental implants to a lesser degree. It is currently unclear whether vitamin D gene polymorphisms constitute risk factors for periodontitis. Higher levels of vitamin D can favor nonsurgical and surgical periodontal treatment outcomes, which can be achieved through a combination of dietary changes, increased sunlight exposure, and supplementation. Serum levels of vitamin D should be In the skin, the precursor of vitamin 7-dehydrocholesterol (7-DHC) is converted into pre-vitamin D3 and vitamin D3 when exposed to UVB radiation. Diet and/or supplements are additional sources of vitamin D. From the skin and small intestine, vitamin D binds to vitamin D-binding protein (DBP) for transport to the liver via blood circulation. In the liver, vitamin D is converted into 25-hydroxyvitamin D (25(OH)D). In the kidneys, 25(OH)D is converted into 1,25(OH)2D, which is the active vitamin D metabolite responsible for its endocrine, autocrine, and paracrine functions.Autoimmune diseases, infectious diseases, type 2 diabetes, preeclampsia, hypertension, cardiovascular disease, oral diseases, neurological disease, osteoporosis, different types of cancer, and higher overall mortality have been associated with vitamin D deficiency [6,7]. Deficiency is generally defined as values of 25(OH)D below 30 ng/ml [2,8,9]. It constitutes a public health challenge, affecting approximately 1 billion people around the globe. Insufficiency or subclinical deficiency can affect upto 50% of the world population [10,11]. General factors that contribute to low vitamin D levels and include decreased dietary intake, limited exposure to sunlight, reduced endogenous synthesis due to certain diseases, and lower hepatic catabolism due to certain medications [12]. Older age, obesity, dark skin, and conditions that change fat metabolism constitute additional factors that affect vitamin D status. Severe deficiency leads to incomplete mineralization of osseous tissues, which manifests as rickets in children, and oste...

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Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements

Cited by 12 publications

References 30 publications

Impact of Vitamin D3 Supplementation on Dental Implant Stability

Impact of Vitamin D3 Supplementation on Dental Implant Stability

Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review

The Role Of Vitamin D In Periodontal And Peri-Implant Health

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