Comparative Evaluation of Filters Used in Membrane Plasmapheresis

Gurland, Hans J.; Lysaght, Michael J.; Samtleben, W.; Schmidt, Bernhard

doi:10.1159/000183148

Cited by 34 publications

(12 citation statements)

References 6 publications

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“…Too high pressures within the plasmapheresis blood compartment might be important in induc ing mechanical damage to blood compo nents, and should be avoided [ 14], As already noticed by Gurland [ 15], over all filtration proved to be quite independent of available membrane area. The CPS-10 fil ter of 0.17 m2 performed as well as the Plas maflo Hi-05 having at least 3 times as much surface area.…”

Section: Discussionmentioning

confidence: 99%

Single-Needle Membrane Plasmapheresis

Lambrecht¹,

Vanholder²,

Ringoir³

1988

Blood Purif

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Plasma filtration characteristics of three hollow fiber plasma separation filters (Plasmaflo Hi-05, Extraplex BL 550 and CPS-10®⁾ were studied in a single-needle setting by means of the double headpump. Plasma exchange was carried out in 12 patients during a total number of 59 sessions. For each filter, a mean total ultrafiltration volume of ± 3,000 ml was obtained over a period from 92 to 121 min. The lowest and highest obtained mean filtration flows were 26.7 ± 2.5 and 36.6 ± 1.7 ml/min for Extraplex BL 550 and CPS-10, respectively (p < 0.01). The pre- and postplasmapheresis pressures, measured in the bubble trap chamber as an indirect estimation of transmembrane pressure, were lower for the Plasmaflo Hi-05 than for the two other filters under study; pressures remained unaltered during the session. Blood pressure showed a minor but significant decline during plasmapheresis with the Plasmaflo filter. A reduction after plasmapheresis by more than 40 % of the immunoglobulins IgE, IgG, IgM and IgA, and of complement factors C3 and C4 was seen for each of the filters and no significant differences between the filters were observed. An additional study on 6 filters with constant blood flow and TMP showed minor differences in the trans-membrane pressure necessary to obtain a given filtration volume per unit of time and similar sieving coefficients for immunoglobulins. This study demonstrates that with this single-needle technique a satisfying immunoglobulin extraction performance was obtained for each of the filter types studied; however, there existed minor but significant differences in the patient hemodynamic status according to the membrane used.

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Section: Discussionmentioning

confidence: 99%

Single-Needle Membrane Plasmapheresis

Lambrecht¹,

Vanholder²,

Ringoir³

1988

Blood Purif

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“…When therapeutic plasma exchange is performed with a highly permeable filter and standard dialysis equipment, it is often referred to as membrane plasma separation (MPS). Having undergone considerable investigation and use in both Europe and Japan,21,22 MPS has become increasingly popular in the United States 23‐26. There have also been numerous articles detailing the technical and nursing management of the MPS system 27‐29.…”

Section: Tpe With Dialysis Equipmentmentioning

confidence: 99%

Why nephrologists should perform therapeutic plasma exchange

Kaplan

2009

Dialysis & Transplantation

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“…According to another approach, the siev ing coefficient is derived from the pre-and postcapillary plasma concentrations in rela tion to the filtrate concentration and was found to be 0.97 for IgG with the continuous exchange technique [Gurland et al" 1984]. According to this approach, we calculated also a sieving coefficient of 0.97 for IgG in 1 patient treated by the single-needle tech nique.…”

Section: Aucmentioning

confidence: 99%

Membrane Plasma Exchange by Single-Needle Hemofiltration Device

Wilms¹,

Keller²,

Offermann³

1984

Blood Purif

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Membrane plasma exchange can be performed by the use of a double-pump hemofiltration device with only one central venous Shaldon catheter. According to this single-needle technique the intermittent blood flow is controlled by pressure monitoring resulting in a continuous filtration flow of 70 m1/min which is quantitatively replaced by an albumin (30 g/l) substitution fluid. Thus, a 4,000-m1 plasma exchange can be performed within 1 h and an equal or even better sieving coefficient for IgG (S = 0.81) is achieved compared with the continuous technique using two vascular accesses.

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Comparative Evaluation of Filters Used in Membrane Plasmapheresis

Cited by 34 publications

References 6 publications

Single-Needle Membrane Plasmapheresis

Single-Needle Membrane Plasmapheresis

Why nephrologists should perform therapeutic plasma exchange

Membrane Plasma Exchange by Single-Needle Hemofiltration Device

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