Comparative evaluation of ibuprofen co-crystals prepared by solvent evaporation and hot melt extrusion technology

Kshirsagar, Sharvari M.; Chatale, Bandoo C.; Amin, Purnima D.

doi:10.1016/j.jddst.2021.103003

Cited by 10 publications

(1 citation statement)

References 18 publications

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“…Co-crystallization method using heat is a novel method to form co-crystals. It has several advantages compared with the solvent evaporation method such as it does not need any organic solvent and can be used without drug coformer solubility determination that is a time-consuming and laborious work [29].…”

Section: Heat-induced Co-crystallizationmentioning

confidence: 99%

Chemistry and Modern Techniques of Characterization of Co-Crystals

Ali¹,

Кузнецов²,

Ibrahim³

et al. 2023

Drug Formulation Design

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Co-crystals are multicomponent molecular materials held together through non-covalent interactions that have recently attracted the attention of supramolecular scientists. They are the monophasic homogeneous materials where a naturally occurring pharmaceutical active ingredient (API) and a pharmaceutically acceptable co-crystal former are bonded together in a 1:1 via non-covalent forces such as H-bonds, π–π, and van der Waals forces. Co-crystallization is a promising research field, especially for the pharmaceutical industry, due to the enormous potential of improved solubility and bioavailability. Co-crystals are not the only multicomponent molecular materials, as there are many other forms of multicomponent molecular solids such as salts, hydrates, solvates, and eutectics. The formation of co-crystals can roughly be predicted by the value of ∆pKa, that is, if the ∆pKa is more than 3, then this monophasic homogeneous material usually falls in the category of salts, whereas if the ∆pKa is less than 2, then co-crystals are usually observed. A number of methods are available for the co-crystal formation, broadly classified into two classes established on state of formation, that is, solution-based and solid-based co-crystal formation. Similarly, a number of techniques are available for the characterization of co-crystals such as Fourier transforms-infrared spectroscopy, single-crystal and powder X-ray diffraction, etc. In this chapter, we will discuss the available methods for co-crystallization and its characterization.

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Section: Heat-induced Co-crystallizationmentioning

confidence: 99%