Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat

Çimen, Üzeyir; Yılmaz, Atakan; Cimen, Yesim Kinaci; Seyit, Murat; Özen, Mert; Erdur, Bülent; Turkcuer, Ibrahim; Oncel, Gizem

doi:10.1111/ijcp.14511

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…There was no significant difference between groups in terms of the mean DSS, SPIS, SwoTS, and STRS scores at the examined time points. Both drugs reduced the sore throat equally [17].…”

Section: Resultsmentioning

confidence: 93%

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New Studies on Dexketoprofen

Kuczyńska

Pawlak

Nieradko-Iwanicka

2021

Polish Hyperbaric Research

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Introduction. Dexketoprofen(DEX) belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) and has analgesic, anti-inflammatory, and antipyretic properties. DEX is an enantiomer of ketoprofen (S+) and has a stronger effect than ketoprofen. It is highly effective even after the administration of small doses. The therapy with DEX does not cause serious side effects and is additionally tolerated by the body. Aim. The review aimed to find original scientific publications on DEX in recent years and its therapeutic efficacy, safety, and tolerability. Method. A systematic review of scientific articles published no earlier than 2015 was carried out. Materials from the PubMed, Google Scholar, and Medline Complete databases were used. The literature review was carried out in November 2021. Among the publications found, 28 scientific articles were selected for analysis. Results and discussion. Over the recent years, there have been many publications about DEX. Articles describing new data on DEX in the treatment of pain were analyzed, compared with other drugs and mesotherapy, the latest reports of its combination with tramadol and thiocolchicoside were reviewed, and a new slow release form of DEX and new therapeutic applications of this drug were investigated. After analyzing all the studies, it was found that DEX produced similar or more effective analgesia compared to other drugs and reduced the need for emergency medications. In addition, it was noted that using DEX in combination therapy was far better than taking it alone, and was also found to be effective in raising the epileptic threshold. Mesotherapy achieved higher results in the treatment of pain symptoms compared to DEX. The side effects that appeared as a result of the use of DEX therapy were not life-threatening. Conclusion. The results of the review confirm that DEX is a very good analgesic, which is more potent than paracetamol and diclofenac sodium while having similar effects to dexmedetomidine and lidocaine. DEX in combination with tramadol or thiocolchicoside is more effective than when the two drugs are used alone. Scientists are working on the long-acting DEX and are looking for new applications of the drug in epilepsy and oncology.

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“…There was no significant difference between groups in terms of the mean DSS, SPIS, SwoTS, and STRS scores at the examined time points. Both drugs reduced the sore throat equally [17].…”

Section: Resultsmentioning

confidence: 93%

“…Cimen U. et al compared intravenous DEX with paracetamol for the treatment of sore throat pain in a randomized, prospective, controlled, double-blind study [17]. Two hundred adult patients were enrolled in the study and divided into two groups.…”

Section: Resultsmentioning

confidence: 99%

New Studies on Dexketoprofen

Kuczyńska

Pawlak

Nieradko-Iwanicka

2021

Polish Hyperbaric Research

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“…A prospective randomised controlled double-blind study investigating the efficacy of intravenous dexketoprofen and paracetamol in resolving pain caused by sore throat reported that both exhibited similar analgesic effects by reducing throat pain to a comparable extent. 26 However, German guidelines recommend ibuprofen or naproxen for symptomatic therapy in acute pharyngitis and only offer weak support for the use of throat preparations (pastilles, gargle solutions or sprays) containing local anaesthetics and/or non-steroidal anti-inflammatory drugs. 27 It should be remembered that the throat preparations prescribed as symptomatic therapy provide, at best, low effectiveness for a brief period against self-limiting symptoms.…”

Section: Implications For Research and Practicementioning

confidence: 99%

Knowledge, attitudes and practices of general practitioners and paediatricians towards Group A beta-haemolytic streptococcal tonsillopharyngitis: A cross-sectional study from Türkiye

Akca,

Sahin

2023

Aust J Gen Pract

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Background and objectiveGeneral practitioners (GPs) and paediatricians are very important in the management of sore throat in terms of providing correct diagnosis and treatment. The aim of this study was to evaluate the knowledge, attitudes and practices of GPs and paediatricians towards Group A beta-haemolytic streptococcal (GABHS) tonsillopharyngitis. MethodsThree vignettes/case studies, in which the causative agents were GABHS, Epstein-Barr virus (EBV) and non-EBV viral infection, were presented as part of a questionnaire sent to paediatricians and GPs to elicit information regarding their diagnosis and treatment of tonsillopharyngitis. ResultsIn all, 236 physicians responded to the questionnaire (126 paediatricians, 106 GPs). GPs registered more accurate diagnoses of GABHS tonsillopharyngitis and tended to administer more symptomatic treatment in the case of non-EBV tonsillopharyngitis than paediatricians. Paediatricians requested more tests in the diagnosis of GABHS tonsillopharyngitis than GPs. DiscussionMost GPs and paediatricians possess adequate knowledge regarding GABHS diagnosis and the differential diagnosis of patients. Differences between the hospital and general practice settings may have affected the approach to symptomatic treatment and requesting tests.SORE THROAT is one of the most common and frequently seen complaints in children. 1 Because viral infections are responsible for most cases of acute pharyngitis in children, most paediatric patients with a sore throat do not require antibiotic therapy. 2 However, antibiotics are frequently and inappropriately prescribed for children with a sore throat, even in high-income countries. 3,4 This results in considerable spending on unnecessary healthcare and in antimicrobial resistance in the community. 5,6 The most frequent bacterial cause for which antibiotic therapy is definitely required in the case of acute pharyngitis is Group A beta-haemolytic streptococcus (GABHS), seen in 30% of cases of sore throat in the paediatric population. 7 Streptococcal infections can lead to life-threatening non-suppurative complications (eg acute rheumatic fever, glomerulonephritis and paediatric autoimmune neuropsychiatric disorders) and suppurative complications (peritonsillar abscess, septic jugular vein thrombophlebitis, Vincent's angina) requiring emergency medical or surgical intervention. 8 Complications such as acute rheumatic fever, which are responsible for significant mortality and morbidity, are 100-200% more prevalent in low-and middleincome countries than in high-income countries. 9 However, because the signs and symptoms of GABHS pharyngitis cannot generally be differentiated from other causes of sore throat, diagnosis is difficult. 10 GABHS pharyngitis has potentially life-threatening complications, whereas viral pharyngitis does not even require antibiotics; so, the decision process is important for clinicians. Diagnostic and therapeutic guidelines are available to standardise clinician approaches. 7,[11][12][13] COVID-19 spread across the globe at ...

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A novel method for decision-making approach using multi-fuzzy soft systems with applications in analyzing the ımpact of two distinct drug categories

Şanlıbaba,

Jana

2024

Comp. Appl. Math.

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Comparative evaluation of intravenous dexketoprofen and paracetamol in the management of pain induced by sore throat

Cited by 4 publications

References 13 publications

New Studies on Dexketoprofen

New Studies on Dexketoprofen

Knowledge, attitudes and practices of general practitioners and paediatricians towards Group A beta-haemolytic streptococcal tonsillopharyngitis: A cross-sectional study from Türkiye

A novel method for decision-making approach using multi-fuzzy soft systems with applications in analyzing the ımpact of two distinct drug categories

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