Comparative evaluation of NovaMin desensitizer and Gluma desensitizer on dentinal tubule occlusion: a scanning electron microscopic study

Abstract

PurposeIn this study, the effect of calcium sodium phosphosilicate (NovaMin) desensitizing agent, which is a powder-based system, and hydroxyethyl methacrylate and glutaraldehyde (Gluma desensitizer), which is liquid-based system, on dentinal tubule occlusion was analyzed by scanning electron microscope. The effects of the above two along with one control group were compared to determine the more effective method of sealing the dentinal tubules after initial application.MethodsTwenty specimens were allocated to each of 3 groups: Control, Gluma desensitizer, and NovaMin. Two additional samples were also prepared and treated with Gluma and NovaMin; these samples were longitudinally fractured. The specimens were prepared from extracted sound human premolars and were stored in 10% formalin at room temperature. The teeth were cleaned of gross debris and then sectioned to provide one to two dentin specimens. The dentin specimens were etched with 6% citric acid for 2 minutes and rinsed in distilled water. Control discs were dried, and the test discs were treated with the desensitizing agents as per the manufacturer's instructions. The discs as well as longitudinal sections were later analyzed under the scanning electron microscope. The proportions of completely occluded, partially occluded, and open tubules within each group were calculated. The ratios of completely and partially occluded tubules to the total tubules for all the groups was determined, and the data was statistically analyzed using nonparametric tests and statistical significance was calculated.ResultsNovaMin showed more completely occluded tubules (0.545±0.051) while Gluma desensitizer showed more partially occluded tubules (0.532±0.075). The differences among all the groups were statistically significant (P≤ 0.05).ConclusionBoth materials were effective in occluding dentinal tubules but NovaMin appeared more promising in occluding tubules completely after initial application.

Effectiveness of various toothpastes on dentine tubule occlusion

“…68 Several in vitro studies demonstrated a good occluding effect of Pro-Argin technology on open dentine tubules. 34,[69][70][71][72] Clinical studies of Pro-Argin technology supported the in vitro results and showed instant relief of dentine hypersensitivity. 24,73 Currently, no in vitro or in vivo studies regarding the occluding effects of zinc-carbonate hydroxyapatite on dentine tubules are available; only reports regarding the effects of zinc-carbonate hydroxyapatite on enamel have been published.…”

“…30,31 Calcium sodium phosphosilicates precipitate onto dentine collagen as calcium phosphate and silicate, forming deposits on the dentine surface and in dentine tubules. [32][33][34][35][36] These precipitates are water-and acid-resistant. Randomized controlled clinical studies of calcium sodium phosphosilicates have shown the effective treatment of dentine hypersensitivity compared to controls.…”

Effect of GLUMA desensitizer on the retention of full metal crowns cemented with Rely X U200 self-adhesive cement

“…Glutaraldehyde results in the coagulation of amino acids and proteins in dentinal tubules and works as an effective disinfectant. HEMA can effectively seal the dentinal tubules 22. Our hypothesis regarding the effect of GLUMA desensitizer on self-adhesive cement bond to dentin and the selection of these two materials were based on the study by Munksgaard and Asmussen in 1984.…”

Efficacy of Diode Laser and Gluma on Post‐Preparation Sensitivity: A Randomized Split‐Mouth Clinical Study

“…Desensitizing agents can plug the dentinal tubules and make them less responsive to stimulation by two mechanisms . They can either form a resin seal over the dentinal surface with or without light‐curing or precipitate proteins or crystals into and around dentine tubules by rubbing action with a brush or cotton pellet …”