Comparative evaluation of plasma ROM levels in chronic periodontitis patients before and after non-surgical and surgical periodontal therapy: A clinical trial

Abstract

Objective:Chronic periodontitis (CP) is associated with increased levels of blood reactive oxygen species (ROS). So, treatment of CP may lead to decrease in blood ROS. However, not much literature is available comparing the effect of surgical and non-surgical periodontal treatment on blood ROS levels. Reactive oxygen metabolites (ROMs) are a useful measure of blood ROS. The aim of this study was to investigate the effect of periodontal treatment on plasma ROM levels in CP patients.Materials and Methods:Thirty CP patients and 15 controls were monitored. Plasma samples were collected at baseline and the clinical parameters were recorded. The CP patients were randomly divided into two groups: Scaling and root planing (Group II) and periodontal flap surgery (Group III). Both groups were re-evaluated 1 and 2 months after therapy. Clinical parameters were reviewed, plasma samples collected, and ROM levels were determined using a spectrophotometric technique.Results:At baseline, the ROM levels for Group II and Group III were 519.8 ± 62.4 and 513.4 ± 74.7 CARR U, respectively, which were higher than Group I value (282.9 ± 23.9, P < 0.001). Periodontal treatment in CP patients resulted in improvement of clinical parameters and a highly significant reduction in plasma ROM level (P < 0.001) after 2 months. Also, there was a more significant reduction in plasma ROM levels in Group III as compared to Group II (P < 0.05).Conclusions:In CP patients, surgical periodontal treatment was more effective in lowering the plasma ROM levels than when non-surgical periodontal treatment was performed alone and, therefore, may be more beneficial in reducing systemic oxidative stress.

The effect of periodontal therapy on oxidative stress biomarkers: A systematic review

“…The search strategy yielded 3,199 studies, but just 20 fulfilled the inclusion criteria (Akpinar, Toker, Ozdemir, Bostanci, & Aydin, ; Bostanci, Toker, Senel, Ozdemir, & Aydin, ; Chaudhary, Gowda, Mehta, & Kumar, ; Cifcibasi et al., ; Dede, Ozden, & Avcı, ; Grant, Brock, Matthews, & Chapple, ; Guentsch et al., ; Hendek, Erdemir, Kisa, & Ozcan, ; Koromantzos et al., ; Kurgan et al., ; Marcaccini et al., ; Mizuno et al., ; Muthuraj et al., ; Novakovic et al., ; Önder et al., ; Patel, Rao, & Pradeep, ; Singh, Chander Narula, Kumar Sharma, Tewari, & Kumar Sehgal, ; Tamaki, Tomofuji, Ekuni, Yamanaka, & Morita, ; Toker, Akpınar, Aydın, & Poyraz, ; Wei, Zhang, Wang, Yang, & Chen, ). Figure summarizes the flow chart of the inclusion process, and the reasons for exclusions are expressed in Supporting Information Table .…”

“…The majority of the included studies were non‐RCTs (Akpinar et al., ; Bostanci et al., ; Cifcibasi et al., ; Dede et al., ; Grant et al., ; Guentsch et al., ; Hendek et al., ; Kurgan et al., ; Marcaccini et al., ; Muthuraj et al., ; Önder et al., ; Patel et al., ; Singh et al., ; Tamaki et al., ; Toker et al., ; Wei et al., ). Four studies were RCTs (Chaudhary et al., ; Koromantzos et al., ; Mizuno et al., ; Novakovic et al., ). All the included studies were written in English.…”

“…Regarding the systemic conditions of the included participants, 16 studies included only systemically healthy individuals (Akpinar et al., ; Chaudhary et al., ; Cifcibasi et al., ; Dede et al., ; Grant et al., ; Guentsch et al., ; Hendek et al., ; Kurgan et al., ; Marcaccini et al., ; Önder et al., ; Patel et al., ; Singh et al., ; Tamaki et al., ; Toker et al., ; Wei et al., ), three studies included only patients with type II diabetes (Koromantzos et al., ; Mizuno et al., ; Muthuraj et al., ), and one study included individuals with Mediterranean fever (Bostanci et al., ). Seven studies included smokers (Akpinar et al., ; Guentsch et al., ; Hendek et al., ; Kurgan et al., ; Mizuno et al., ; Önder et al., ; Toker et al., ), while the other studies included only nonsmokers (Bostanci et al., ; Chaudhary et al., ; Cifcibasi et al., ; Dede et al., ; Grant et al., ; Koromantzos et al., ; Marcaccini et al., ; Muthuraj et al., ; Novakovic et al., ; Singh et al., ; Tamaki et al., ; Wei et al., ). Regarding periodontal diagnosis, only one study involved patients with aggressive periodontitis (Cifcibasi et al., ), and the others included individuals with chronic periodontitis.…”

“…Four studies were evaluated by the Cochrane Collaboration tool, and Figure summarizes this analysis (Chaudhary et al., ; Koromantzos et al., ; Mizuno et al., ; Novakovic et al., ). For all studies, blinding of participants and personnel was not considered applicable, as all RCTs included periodontal healthy individuals (Chaudhary et al., ; Novakovic et al., ) and/or did not involve periodontal therapy (Koromantzos et al., ; Mizuno et al., ; Novakovic et al., ). Three studies presented low risk of bias for the randomization process (Koromantzos et al., ; Mizuno et al., ; Novakovic et al., ).…”

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

“…[18][19][20][21] This study was of the short duration needs evaluation on a long-term basis. The reason for Small sample size selected for the study and for quantitative research design because of lack of use of probability sampling techniques and limits the ability to make broader generalization from present results.…”