Comparative evaluation of platelet-rich fibrin membrane and collagen membrane along with demineralized freeze-dried bone allograft in Grade II furcation defects: A randomized controlled study

Abstract

Background:The management of the furcation areas in multirooted teeth is often challenging due to difficulty in access. Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has shown to accelerate the healing of soft and hard tissues. This study was designed to evaluate the efficacy of autologous PRF as a membrane in treatment of Grade II furcation defects in molars as compared to collagen membrane along with demineralized freeze-dried bone allograft in both the groups.Materials and Methods:A split-mouth study was planned with 18 patients having 2 sites of Grade II furcation defects each. Random allocation of the defect site was done for the test and control group. Plaque index, probing depth (PD), relative vertical clinical attachment level (RVCAL), gingival marginal level, and radiographic bone levels were recorded at baseline, 3 months, and 6 months postoperatively.Results:Both the groups showed statistically significant outcomes in intragroup comparison from baseline to 3 and 6 months. However, there was no statistical difference between PRF membrane and collagen membrane groups on intergroup comparison.Conclusion:There was a significant reduction of PD, improvement in RVCAL, and defect fill with autogenous PRF as membrane. This indicates its role as a regenerative material in treating furcation defects, which can be used as alternative to other expensive membranes.

Biofunctionalization of porcine-derived collagen matrices with platelet rich fibrin: influence on angiogenesis in vitro and in vivo

“…A plentitude of studies suggest that PRF may be used for optimized soft tissue healing in regenerative medicine and periodontology [10,11] and, in addition, may even show antimicrobial capacity namely against periopathogens such as Porphyrymona gingivalis [31]. However, a recent cochrane review defines the evidence for the use of PRF for treating intrabony defects insufficient [32].…”

“…Since the introduction of the PRF in 2001 by Choukroun et al, it is widely used to support oral soft tissue regeneration [9]. In the literature, there is evidence that PRF can be successfully used in the therapy of gingival recession or intrabony defects in periodontology [10,11], in reducing pain and swelling after third molar removal [12], implant stability [13] and other aspects of regenerative medicine [14,15]. It is chair side produced via specific centrifugation after venous blood collection and can be processed as a liquid, injectable or stable PRF respectively.…”

Comparative evaluation of platelet rich fibrin matrix (PRFM) membrane and collagen membrane with demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular class II furcation defects: A randomized controlled trial

“…49 The mean PPD reduction (0.16AE0.71 mm; p=0.43) in our study is supported by evidence, which shows PPD decrease by employing DFDBA with and without PRF in the management of class II furcation defects and showed statistical significant PI score (p<0.001) at six months compared to baseline. 17,50 In this study, the test group had a gain RGML (0.25AE0.62) than control group (0). Sharma et al 51 found that the PRF group (0.344AE0.086) had similar GML alterations to the OFD group (0.756AE0.115) in their study.…”

“…In the present study, both groups showed no statistically significant difference for mean CAL gain-0.41AE1.08; p=0. 50 where statistical non-significant difference found in RHCAL (p= 0.055) with combination therapy. The use of PRFM and collagen membrane along with bone graft has led to a demonstrable CAL gain in furcation defects, thus indicating a regenerative potential of both the membranes.…”

Effectiveness of Platelet-Rich Fibrin with Decalcified Freeze-Dried Bone Allograft Compared to Decalcified Freeze-Dried Bone Allograft Alone in Mandibular Grade-II Furcation Defects: A Quasi-Experimental Study

“…Also, in grade II furcation defects DFDBA along with amniotic membrane has resulted in greater volumetric changes than DFDBA alone [14]. Mehta et al [15] reported that PRF, compared to collagen membranes and DFDBA, resulted in greater regenerative potential for grade II furcation defects. Basireddy et al [16] analyzed the benefit of PRF and DFDBA in grade II mandibular furcation defects and found a statistically significant difference with respect to only Relative horizontal clinical attachment level gain and Gingival margin level change.…”