Comparative Evaluation of Platelet-rich Fibrin and Mineral Trioxide Aggregate as Pulpotomy Agents in Permanent Teeth with Incomplete Root Development: A Randomized Controlled Trial

Keswani, Deepa; Pandey, Ramesh Kumar; Ansari, Afroz Alam; Gupta, Shalini

doi:10.1016/j.joen.2014.01.009

Cited by 37 publications

(47 citation statements)

References 29 publications

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“…Certain studies also indicated that PRF increases HDPC proliferation and differentiation (5,11), which is consistent with the results of the present study. PRF has been applied in vital pulp therapy in a preclinical trial (12) and a case report (13), where good outcomes were suggested. The application of CGF in vital pulp therapy is rare and the effect of CGF on HDPC has remained to be determined.…”

Section: Discussionmentioning

confidence: 99%

Effect of five dental pulp capping agents on cell proliferation, viability, apoptosis and mineralization of human dental pulp cells

Dou

Yang

2020

Exp Ther Med

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The aim of the present study was to investigate the effect of calcium hydroxide [Ca(OH) 2 ], mineral trioxide aggregate (MTA), iRoot BP, platelet-rich fibrin (PRF) and concentrated growth factors (CGF) on the proliferation, viability, apoptosis and mineralization of human dental pulp cells (HDPCs). HDPCs were treated with Ca(OH) 2 , MTA, iRoot BP, PRF and CGF exudates. Cell viability, apoptosis, proliferation, cell cycle and alkaline phosphatase (ALP) activity were evaluated in vitro. PRF significantly increased the cell proliferation as compared with that in the MTA and iRoot BP groups on day 3. The CGF group displayed higher proliferation rates as compared with that in the MTA group on days 3 and 7. The MTA group displayed the highest ALP activity on days 1 and 3, and the CGF group on day 7. Ca(OH) 2 inhibited cell proliferation and the percentages of dead and apoptotic cells were relatively higher in the Ca(OH) 2 group on days 1, 3 and 7 compared with those in the other groups. In conclusion, PRF and CGF may be potential pulp-capping materials for vital pulp therapy. Future in vivo studies are required to confirm this.

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Section: Discussionmentioning

confidence: 99%

Effect of five dental pulp capping agents on cell proliferation, viability, apoptosis and mineralization of human dental pulp cells

Dou

Yang

2020

Exp Ther Med

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“…The authors recommended platelet‐rich fibrin as a more economic method for pulp capping (Keswani et al . , Kumar et al . ).…”

Section: Vital Pulp Therapiesmentioning

confidence: 97%

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy

2017

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Mineral trioxide aggregate (MTA) is a bioactive endodontic cement (BEC) mainly comprised of calcium and silicate elements. The cement was introduced by Torabinejad in the 1990s and has been approved by the Food and Drug Administration to be used in the United States in 1997. A number of new BECs have also been introduced to the market, including BioAggregate, Biodentine, BioRoot RCS, calcium-enriched mixture cement, Endo-CPM, Endocem, EndoSequence, EndoBinder, EndoSeal MTA, iRoot, MicroMega MTA, MTA Bio, MTA Fillapex, MTA Plus, NeoMTA Plus, OrthoMTA, Quick-Set, RetroMTA, Tech Biosealer and TheraCal LC. It has been claimed that these materials have properties similar to those of MTA without its drawbacks. In this article, the chemical composition and the application of MTA and other BECs for vital pulp therapy (VPT), including indirect pulp cap, direct pulp cap, partial pulpotomy, pulpotomy and partial pulpectomy, have been reviewed and compared. Based on selected keywords, all papers regarding chemical composition and VPT applications of BECs had been reviewed. Most of the materials had calcium and silicate in their composition. Instead of referring to the cements based on their chemical compositions, we suggest the term 'bioactive endodontic cements (BECs)', which seems more appropriate for these materials because, in spite of differences in their chemical compositions, bioactivity is a common property for all of them. Numerous articles were found regarding use of BECs as VPT agents for indirect and direct pulp capping, partial pulpotomy and cervical pulpotomy. Most of these investigations used MTA for VPT. In most studies, newly introduced materials have been compared to MTA. Some of the BECs have shown promising results; however, the number of their studies compared to investigations on MTA is limited. Most studies had several methodological shortcomings. Future investigations with rigorous methods and materials are needed.

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“…The five included studies were published between 2006 and 2018, two of which were conducted in India [16, 19], one in Iran [15], one in Turkey [18] and one in Egypt [17]. Of the five studies, four were parallel trials and the remaining study was a split-mouth trial.…”

Section: Resultsmentioning

confidence: 99%

“…Of the five studies, four were parallel trials and the remaining study was a split-mouth trial. Of the included studies, two compared MTA with CH [17, 18], one compared CEM with MTA [15], one compared PRF with MTA [16], and one compared MTA, TAP and abscess remedy [19]. Four studies with 232 teeth used each tooth as a unit of analysis [16–19], while the other one with 118 roots used each root as a unit [15].…”

Section: Resultsmentioning

confidence: 99%

Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis

Chen

Zhang

et al. 2019

BMC Oral Health

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BackgroundPulpotomy is one of the most widely used methods in preserving vital pulp in teeth, which is of great significance in achieving continue root formation in immature permanent teeth suffering from dental caries or trauma. The aim of this meta-analysis and systemic review is to synthesize the available evidences to compare different pulpotomy dressing agents for pulpotomy treatment in immature permanent teeth.MethodsElectronic databases including MEDLINE (via Pubmed), EMBASE, the Cochrane library (CENTRAL) and the clinicaltrials.gov database were searched. The references of all included articles or relevant reviews were cross-checked. Only randomized controlled trials (RCTs) comparing two or more pulp dressing agent in permanent teeth with open apex would be included. Also, the studies should have at least 6 months of follow-up, report clinical and radiographic success in detail and publish in English.ResultsFive RCTs were included for a systematic review, and all of them had a high risk of bias. There is little difference in success rate between mineral trioxide aggregate (MTA) and calcium hydroxide (CH) at 6-month follow-up (risk ratio (RR) 1; 95% confidence interval (CI) 0.94 to 1.06) and 12-month follow-up (RR 1.04; 95% CI 0.96 to 1.13). There is no difference between MTA versus platelet-rich fibrin and MTA versus calcium-enriched mixture (CEM). There is only weak evidence of increased success rate in using MTA and triple antibiotic paste (TAP) rather than abscess remedy.ConclusionsBased on the present evidence, similar success rates with MTA were found between the dressing agents CH, CEM, RPF and TAP as pulpotomy-dressing agents in the treatment of immature permanent teeth. More high-quality RCTs are needed in this field in future studies.

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Comparative Evaluation of Platelet-rich Fibrin and Mineral Trioxide Aggregate as Pulpotomy Agents in Permanent Teeth with Incomplete Root Development: A Randomized Controlled Trial

Cited by 37 publications

References 29 publications

Effect of five dental pulp capping agents on cell proliferation, viability, apoptosis and mineralization of human dental pulp cells

Effect of five dental pulp capping agents on cell proliferation, viability, apoptosis and mineralization of human dental pulp cells

Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy

Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis

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