Comparative evaluation of salivary immunoglobulin a levels between pedodontic subjects

Jha, Anju; Singh, Rohit; Jha, Sovendu; Singh, Supriya; Chawla, Riddhi; Prakash, Akanksha

doi:10.4103/jfmpc.jfmpc_967_19

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…In all the saliva sIgA tests, males were found to have greater levels of sIgA than females. This finding is in line with previous studies that found younger males to have significantly higher IgA mean values (p less than 0.05) than females [27,33,34].…”

Section: Discussionsupporting

confidence: 93%

“…All participants were asked not to eat or drink 1 hour before unstimulated saliva was collected. To prevent any variation in saliva concentrations due to the influence of circadian rhythm, a morning appointment was scheduled (10-11 a.m.) [27]. All saliva samples were collected in sterile containers, and saliva was collected by the passive saliva method; the participant was asked to collect saliva on the floor of the mouth and then spit it into a pre-labeled bag Sterile container.…”

Section: Collection Of Salivamentioning

confidence: 99%

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The Effect of Dental Implants on Secretory Iga Level in Saliva

TAM,

FMA,

et al. 2024

Int J Dent Oral Health

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Background and aims: The host immune response is altered by a series of physiological and pathological factors such as age, gender, inflammation, surgery, and medications. This study was conducted to evaluate differences in salivary IgA (S-IgA) levels in individuals who underwent dental implant surgery and compare them to individuals who were not exposed to dental treatments. S-IgA levels were determined at least 3 months after implant installation. Methods: A total of 60 healthy individuals were included in the study; 30 participants received implant treatment (Implant Group) and were compared with 30 participants with no implant treatment as controls (Control Group). 1.5 ml of unstimulated saliva was obtained for all participants. The quantitative enzyme-linked immunosorbent assay (ELISA) technique was used for the measurement of salivary IgA levels. Results: The age range of the participants in the implant group was 38-62 years, with a mean age of 47.9 years; 18 (60%) were males and 12 (40%) were females. The age range of the study's controls was 38-59 years, with a mean age ± SD of 45.2 ± 5.2 years for 18 (60%) males and 12 (40%) females. The mean number of implants was 2.7 ± 0.83, and the mean period after implant placement was 19.2 ± 8.2 months. A low sIgA level (< 250 μg/mL) was present in 10% of implant patients, but not in any cases in the control group. In contrast, only 6.7% of implant patients had this amount at a level greater than 351 μg/mL, compared to 53.3% in the control group. The mean ± SD for cases was 302.7 ± 36.8 g/mL versus 370.8 ± 59.2 μg/mL for controls, indicating that all normal distribution values were significantly lower in the implant patient group compared to higher values in healthy controls. Males had higher normal values across the board in both groups (cases and controls). Male dental implant patients' mean and standard deviation (312.2 ± 38.3 vs. 408.2 ± 42.2 µg/ml) showed a statistically significant decrease. Female dental implant patients' mean and standard deviation (287.3 30.6 vs. 314.7 ± 27.6 µg/ml) showed a statistically significant decrease. Overall, there was a significant decrease in the mean ±SD of dental implant patients (302.7 ± 36.8 µg/ml) versus the rising level in the total healthy control group (370.8 ± 36.8 µg/ml). The observed averages of sIgA for the presence of peri-implant mucositis in the two independent samples (yes, no) differed significantly by 60.7, with a 95% confidence interval of 41.1-80.3, and this finding is very significant (p<0.0001). Conclusion: Salivary immunoglobulin A level values were significantly lower statistically in implant patients compared to the control group. The results, however, showed that there is a connection between lower sIgA levels in saliva and the development of pre-implant mucositis, meaning that low sIgA levels are risk factors for peri-implant mucositis or that peri-implant mucositis causes lower sIgA levels to be produced in mouth saliva.

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Section: Discussionsupporting

confidence: 93%

Section: Collection Of Salivamentioning

confidence: 99%

The Effect of Dental Implants on Secretory Iga Level in Saliva

TAM,

FMA,

et al. 2024

Int J Dent Oral Health

View full text Add to dashboard Cite

show abstract

“…This immunoglobulin specifically binds and agglutinates cariogenic bacteria, thus preventing cariogenic bacteria from adhering to dental or mucosal surfaces. Antimicrobial sIgA interacts with antibodies that bind to specific antigens on the bacterial cell wall, leading to bacterial leukocyte agglutination [17,18]. The flow of saliva can be stimulated, either mechanically or chemically.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Black Tea on Secretory IgA from Saliva in Caries and Caries-Free Subjects

Fitri,

Yendriwati,

Astari

et al. 2024

JBBBE

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The crucial role of saliva in the prevention of dental caries is associated with the regulation of its flow rate as well as salivary protein. Black tea, derived from the plant Camellia sinensis, contains catechins and has been shown to have a beneficial effect on saliva in preventing tooth decay. Nevertheless, research on the oral health benefits of black tea is still limited. This study aimed to investigate the effects of black tea (Camellia sinensis) on salivary pH (potential hydrogen), salivary flow rate, lysozyme, and sIgA levels in caries and caries-free patients. The study used a quasi-experimental design with a pre-test and a post-test. Twenty six subjects (male or female) were selected and divided into two groups (caries and caries free), thirteen subjects for each. Saliva samples were obtained before and thirty minutes after tea consumption. The flow rate of saliva was measured by dividing the weight of saliva collected by the time. At the same time, secretory immunoglobulin A (sIgA) levels were analyzed by enzyme-linked immunosorbent assay (ELISA). The t-dependent and t-independent tests and Mann-Whitney tests were selected to evaluate the effect of drinking black tea on salivary flow rate and sIgA value. The results showed that black tea significantly increased salivary flow rate but did not significantly affect the concentration of sIgA. No statistically significant differences in salivary flow rate and sIgA were observed between patients with and without caries after tea consumption. Although the concentration of sIgA did not demonstrate a significant change, however, the salivary flow rate was significantly enhanced. Therefore, drinking black tea did not negatively affect the saliva in the oral cavity, suggesting it can be a good option for daily consumption due to its protective role against dental caries.

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