Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial

Abstract

Adjunctive use of locally delivered 1.2% RSV and 1% MF gel stimulates a significant PD reduction, CAL gains and improved bone fill when compared with placebo gel. Results were significantly better with the use of 1.2% RSV gel than 1% MF gel.

The adjunctive use of host modulators in non‐surgical periodontal therapy. A systematic review of randomized, placebo‐controlled clinical studies

“…Remarkably, metformin gel was superior in terms of PPD reduction in comparison with aloe vera gel, but it was inferior to 1.2% rosuvastatin gel (Kurian et al, ; Pankaj et al, ).…”

Contribution of Statins towards Periodontal Treatment: A Review

“…Concerning locally applied statins, most clinical studies investigated the 1.2% dose (mainly atorvastatin, simvastatin, and rosuvastatin) [20, 23, 125, 126]. Therefore, other doses should be tested to compare efficacy.…”

“…In several preclinical and clinical studies, statins have exhibited contradictory results [21–23] depending on the mode of delivery (local vs systemic), anatomy and severity of the lesions, type of disease, and treatment approach (nonsurgical vs surgical). Therefore, the aim of this literature review was to establish a better understanding of the prophylactic and therapeutic effects of all statin types administered locally or systemically as adjuvant to nonsurgical/surgical periodontal treatment in existing preclinical models and clinical settings and to explore the biological mechanisms underlying these healing and proregenerative effects in the management of periodontitis.…”

Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA‐related kinase 7 (Nek7) expression

“…To date, there are no reported inhibitors of Nek7. Thanks to abundant reports on metformin use, we determined that Nek7 shared an interesting similarity with metformin as a mediator both in inflammation and the cell cycle. During diabetic periodontitis, endoplasmic reticulum and oxidative stress, which have been discovered to dramatically increase potassium efflux and lead to inflammasomes activation, are highly augmented by pathogens and damage, and thus, extensive tissue destruction occurs.…”

“…Metformin has been highly recommended as an effective treatment for diabetes . Its reported effects on chronic periodontitis draw from extensive research . However, little is known about the underlying mechanisms.…”