Comparative evaluation of the efficacy of platelet-rich fibrin and calcium phosphosilicate putty alone and in combination in the treatment of intrabony defects: A randomized clinical and radiographic study

Abstract

Background:Combination of platelet-rich fibrin (PRF) and bone substitutes for the treatment of intrabony pockets is based on sound biologic rationale. The present study aimed to explore the clinical and radiographic effectiveness of autologous PRF and calcium phosphosilicate (CPS) putty alone and in combination in treatment of intrabony defects.Materials and Methods:A total of 45 intrabony defects were selected and randomly divided into three groups. In Group I, mucoperiosteal flap elevation followed by placement of PRF was done. In Group II, mucoperiosteal flap elevation followed by placement of CPS putty was done. In Group III, mucoperiosteal flap elevation followed by placement of PRF and CPS putty was done. Clinical parameters such as gingival index (GI), pocket depth (PD), clinical attachment level (CAL), gingival marginal position and radiographic parameters such as bone fill, changes in crestal bone level, and defect depth resolution were recorded at baseline and after 6 months postoperatively.Results:Statistically significant changes in GI, PD reduction, CAL gain, defect fill, and defect depth resolution from baseline to 6 months were seen in all the three groups (P < 0.05). On intergroup comparison, no statistically significant changes were seen in all clinical parameters. However, the difference in defect fill and defect depth resolution between the Groups I and III and Group II and III was significant.Conclusion:Within limitations of study, combination of PRF and CPS putty showed a significant improvement in PD reduction, CAL gain, and bone fill.

Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

“…This finding could have been because of the placement of the PRF over the graft which in turn, separated and stimulated the interface between the gingival tissue and the root surface preventing epithelial migration. This helps to maintain the flap in a high and stable position, enhances neoangiogenesis and reduces the necrosis and shrinkage of the flap, thus providing maximal root coverage . These findings explain the biologic rationale for the use of a combination of BG and PRF.…”

The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis

“…Initial periodontal therapy, scaling and root planning (SRP) is not frequently resolute at repairing disease-related defects [6,7]. The periodontal wound healing after SRP usually induces the development of a long junctional epithelium, which is responsible for frequent recurrence of a periodontal pocket [8]. To enhance the process of regeneration, the adjunctive therapeutic procedures have been added to the conventional therapy since the end of the last century.…”

“…Platelets have been applied in dentistry over the past three decades. These autologous regenerative tools are concentrated suspensions of supra-physiological amount of growth factors (GFs) and, when applied locally, can induce soft and hard tissue regeneration [8]. Platelets are important reservoirs of various GFs and cytokines, which are vital in wound repair and homeostasis [8].…”

“…These autologous regenerative tools are concentrated suspensions of supra-physiological amount of growth factors (GFs) and, when applied locally, can induce soft and hard tissue regeneration [8]. Platelets are important reservoirs of various GFs and cytokines, which are vital in wound repair and homeostasis [8]. The periodontal wound healing process implies a series of cell-to-cell interactions and molecular signals that are primarily mediated by cytokines and GFs.…”

Combination of platelet rich fibrin and carbonate hydroxyapatite alloplastic bone graft as periodontal tissue engineering in management of chronic periodontitis: a case report

“…11 PRFconsists of a fibrin matrix polymerized with the incorporation of platelets, leukocyte, and cytokines, and circulating stem cells with a specific slow release of growth factors and glycoproteins. 12 An intermediate layer after centrifuge called "buffy coat" or L-PRF where most leucocytes and platelets are concentratedthat stimulates the local environment for differentiation and proliferation of stem and progenitor cells. It acts as an immune regulation node with inflammation control abilities.…”