Comparative evaluation of the prophylactic effect of slow release devices containing homidium bromide and isometamidium on Trypanosoma congolense in rabbits

Clinical and Microbiologic Effects of Subgingivally Delivered 0.5% Azithromycin in the Treatment of Chronic Periodontitis

“…A study by Robert et al 59 tested the bioabsorbability and biocompatibility of a polylactic membrane and showed excellent tissue tolerance with minimal inflammatory reaction. PLGA used in the present study has been widely investigated [28][29][30][31][32][33][34][35][36][37][38] and has regulatory approval as a carrier for the delivery of drugs, including antibiotics. It has been used successfully in the field of periodontology for local delivery of agents such as tetracycline.…”

“…They are biocompatible, exhibit predictable biodegradation kinetics and ease of fabrication, and have regulatory approval, thus showing wide applications in controlled drug delivery 25–27 . The most active area of research using bioabsorbable polymers from glycolide and lactide is in the controlled delivery of pharmaceuticals, such as the antifungal agent fluconazole; 28 the anti‐inflammatory compound piroxicam; 29 antibiotics, including ampicillin, gentamicin, polymyxin B and chloramphenicol, 30–35 and doxorubicin hydrochloride; 36 and narcotic antagonists, including naloxone, naltrexone, L‐methadone, and cyclazocine 37 ,38 . Copolymers from lactic and glycolic acids are more easily degradable than their respective pure polymers 39 .…”

Field Evaluation of the Prophylactic Effect of an Isometamidium Sustained-Release Device against Trypanosomiasis in Cattle

“…After some successful preliminary experiments with rabbits (6,11,13), Geerts et al (12) reported that the prophylactic activities of ISMM and homidium in cattle could be extended significantly by incorporating the drugs in polymers in order to produce sustained-release devices (SRDs). Using a poly(D,Llactide) SRD, an extension of the protection period of ISMM by a factor of 3.2 was obtained.…”