The flow boiling heat transfer performance of R22 and R407c, in a microfin tube with a helix angle of 22° and an apex angle of 48°, was evaluated in a study. The study is aimed at investigating the impact of heat flux, mass flux, saturation temperature, and vapor quality on the heat transfer coefficient during flow boiling. Two different saturation temperatures, 293.15 K and 313.15 K, were used in the experiments, with heat fluxes ranging from 25 to 85 kW.m-2 and mass fluxes ranging from 150 to 350 kg.m-2.s-1. To validate the experimental data, the results were compared with existing correlations for microfin tubes. The calculated error margin among all correlations with the experimental dataset, which ±15% and ±30%, was also matched by 85% and 95% of the datasets, respectively. Findings reveal that at lower saturation temperatures, the average heat transfer coefficients augmented with increasing mass flux. The study also found that R22 has a higher heat transfer coefficient than R407c at low saturation temperatures due to its stronger thermal conductivity and lower viscosity.