Comparative Expression of Novel Vascular Endothelial Growth Factor/Vascular Permeability Factor Transcripts in Skin, Papillomas, and Carcinomas of v-Ha-rasTg.AC Transgenic Mice and FVB/N Mice

Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation

“…In a previous work, we demonstrated the absolute necessity of VEGF signaling for bone gain under mechanical strain as mechanically-induced bone gain was fully prevented by a treatment with neutralizing VEGF antibodies (60). Alternative splicing of primary transcript from a single VEGF pre-mRNA produces at least five different isoforms of which three (VEGF-121, 165 and 189) are more prevalent in human (15) (56) (61).…”

Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review

“…Vascular endothelial growth factor The role of angiogenesis in the production of Tg.AC tumors has been explored though several means (Larcher et al, 1996(Larcher et al, , 1998Tober et al, 1998). Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VGP), stimulates the formation of new capillaries and increases vascular permeability.…”

“…In addition, TPA is able to upregulate VEGF/ VGP expression in mouse skin (Larcher et al, 1996). The four smaller splice variants of VEGF have been identified in Tg.AC and FVB/N skin, papillomas, and carcinomas (Tober et al, 1998). Of interest is a fifth, larger splice variant present during the latter stages of tumor promotion and progression and perhaps related to the presence of v-Ha-ras (Tober et al, 1998).…”

“…The four smaller splice variants of VEGF have been identified in Tg.AC and FVB/N skin, papillomas, and carcinomas (Tober et al, 1998). Of interest is a fifth, larger splice variant present during the latter stages of tumor promotion and progression and perhaps related to the presence of v-Ha-ras (Tober et al, 1998). Its presence in the latter stages may ensure that growth factors, oxygen, and nutrients are able to nourish the tumors by ensuring vascular permeability.…”

Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)

“…There are five isoforms for VEGF-A resulting from alternative splicing of the same gene: VEGF 120 , VEGF 144 , VEGF 164 , VEGF 188 and VEGF 205 (Neufeld et al, 1996;Shima et al, 1996;Tober et al, 1998). Only the three most abundant isoforms, VEGF 120 , VEGF 164 , and VEGF 188 , were detected in the seven pools of RNA from non-TG ovaries and RNA from 20 human mutant TG ovaries, but the level of each was higher in TG ovaries than in non-TG ovaries ( Figure 6).…”