Comparative Fungicidal Activities of N-Chlorotaurine and Conventional Antiseptics against Candida spp. Isolated from Vulvovaginal Candidiasis

Hacıoğlu, Mayram; Oyardı, Özlem; Yilmaz, Fatima Nur; Nagl, Markus

doi:10.3390/jof8070682

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…Compared to quaternary ammonium compounds, OCT exhibits reduced toxicity due to the absence of amide and ester constituents within its chemical composition [29]. Previous studies have reported that OCT demonstrates antifungal and antibiofilm properties [30][31][32][33][34][35]. The current study reveals that OCT effectively inhibits the growth of hyphae in C. albicans, preventing biofilm formation and disrupting mature biofilms.…”

Section: Discussionmentioning

confidence: 56%

Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity

Fang,

Xiong,

Wang

et al. 2023

Antibiotics

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Candida albicans filamentation plays a significant role in developing both mucosal and invasive candidiasis, making it a crucial virulence factor. Consequently, exploring and identifying inhibitors that impede fungal hyphal formation presents an intriguing approach toward antifungal strategies. In line with this anti-filamentation strategy, we conducted a comprehensive screening of a library of FDA-approved drugs to identify compounds that possess inhibitory properties against hyphal growth. The compound octenidine dihydrochloride (OCT) exhibits potent inhibition of hyphal growth in C. albicans across different hyphae-inducing media at concentrations below or equal to 3.125 μM. This remarkable inhibitory effect extends to biofilm formation and the disruption of mature biofilm. The mechanism underlying OCT’s inhibition of hyphal growth is likely attributed to its capacity to impede ergosterol biosynthesis and induce the generation of reactive oxygen species (ROS), compromising the integrity of the cell membrane. Furthermore, it has been observed that OCT demonstrates protective attributes against invasive candidiasis in Galleria mellonella larvae through its proficient eradication of C. albicans colonization in infected G. mellonella larvae by impeding hyphal formation. Although additional investigation is required to mitigate the toxicity of OCT in mammals, it possesses considerable promise as a potent filamentation inhibitor against invasive candidiasis.

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Section: Discussionmentioning

confidence: 56%

Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity

Fang,

Xiong,

Wang

et al. 2023

Antibiotics

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“…However, povidone iodine is less-irritant, favoring its use. Hacioglu et al [21] tested the efficacy of different antiseptics compounds as a potential anti-fungal for isolates of VVC and reported that N-Chlorotaurine was the most effective agent followed by octenidine dihydrochloride and povidone iodine. They advocated the use of N-Chlorotaurine.…”

Section: Candida Glabrata and Candida Krusei]mentioning

confidence: 99%

Use of Povidone Iodine Vaginal Swabbing in Treatment of Recurrent Vulvovaginal Candidiasis

Younis,

Mahmoud,

Elshorbagy

2023

International Journal of Medical Arts

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Article informationBackground: Recurrent vulvovaginal candidiasis [RVVC] is a common condition affecting millions of women worldwide. It is associated with significant morbidity. Vulvovaginal candidiasis affects up to 75% of women of childbearing age once in their life, and up to 9% of women in different populations experience more than three episodes per year, which is defined as recurrent vulvovaginal candidiasis [RVVC].The Aim of the work was to test efficacy of povidone iodine vaginal swabs in treatment of recurrent vaginal candidiasis. Patients and Methods: This study included 210 women, who suffered from symptomatic acute episode of RVVC, and attended Obstetrics and Gynecology Department, Al-Azhar university hospital Damietta. They were divided into three groups: Group A [70 women] who were treated with povidone iodine vaginal swabs. Group B [70 patients] who were treated with oral fluconazole and topical azole therapy. Group C [70 patients] who were treated with a combination of povidone iodine swabs and fluconazole. The overall clinical cure rate and improvement were assessed and compared between groups.Results: There was no significant difference between study groups, regarding overall clinical cure rate, which was higher in group C. As the clinical cure, improvement and no improvement percentage were in group A, 62.8%, 27.2%, 10% respectively. In group B, the values were 60.0%, 28.5%, and 11.5%, respectively. The values in group C were 65.7%, 31.3% and 3.2% with the same order. However, the recurrence rate 6 months after treatment was significantly different between groups [it was 7.9%, 3.2% and 1.47% in groups A, B and C, respectively]. Conclusion:Povidone iodine swabs were effective in treatment of RVVC as medical treatment almost with lower cost and lower side effects with good compliance.

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Silver secnidazole nano‐hybrid emulsion‐based probiotics as a novel antifungal formula against multidrug‐resistant vaginal pathogens

Mosallam,

Helmy,

El‐Bastawisy

et al. 2024

Biotech and App Biochem

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This study presents a novel approach to manage vaginal infections due to Candidiasis, utilizing a novel silver secnidazole nano‐hybrid emulsion (Ag‐Secn‐NHE)‐based probiotics and free Ag‐Secn‐NHE. Ag‐Secn‐NHE was prepared by simple homogenization‒ultrasonication technique and validated by using a ultraviolet‒visible scan, dynamic light scattering, transmission electron microscopy (TEM), Fourier‐transform infrared spectroscopy, and zeta potential. Saccharomyces cerevisiae (RCMB 002Y001) is the most effective probiotic‐producing organism that demonstrates significant effects when combined with Ag‐Secn‐NHE. Ag‐Secn‐NHE‐based probiotics showed significant antifungal effect compared to free Ag‐Secn‐NHE, silver nitrate, silver nanoparticles, secnidazole, secnidazole nanoemulsion, and commercial vaginal wash against multidrug‐resistant vaginal pathogens. The highest inhibitory effect was achieved with Ag‐Secn‐NHE‐based probiotic against Candida auris, Candida albicans, and Cryptococcus neoformans with minimal inhibitory concentration (MIC) 0.625 ± 0.002, 0.00625:1.25 ± 0.012 and 0.00625:1.25 ± 0.032 mg/mL, respectively, in comparison with Ag‐Secn‐NHE that show MIC at 0.00625:1.25 ± 0.612, 0.0125:2.5 ± 0.812, and 0.0125:2.5 ± 0.112 mg/mL (Ag:Secn). Ag‐Secn‐NHE‐based‐ probiotic show minimum fungicidal concentration (MFC) at range from 2.5 to 20 mg/mL, wherever free Ag‐Secn‐NHE show MFC range from 5 to >20 mg/mL. Additionally, Ag‐Secn‐NHE‐based probiotics have 75% inhibition of biofilm formation against C. auris and 60% inhibition of biofilm formation against both Cryptococcus neoformans and C. albicans in comparison with free Ag‐Secn‐NHE. Time‐kill curves showed that the antifungal effect of Ag‐Secn‐NHE‐based probiotics was fungistatic at 2MIC value after 4 h and after 16 h for Ag‐Secn‐NHE. TEM photographs showed that C. auris cells treated with Ag‐Secn‐NHE‐based probiotic formula revealed severe deformations and distored ultrastructural changes. furthermore, results indicated that the Gamma radiation up to 15 kGy increases production of Ag‐Secn‐NHE in comparison with non‐irradiated one.

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Comparative Fungicidal Activities of N-Chlorotaurine and Conventional Antiseptics against Candida spp. Isolated from Vulvovaginal Candidiasis

Cited by 6 publications

References 39 publications

Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity

Unexpected Inhibitory Effect of Octenidine Dihydrochloride on Candida albicans Filamentation by Impairing Ergosterol Biosynthesis and Disrupting Cell Membrane Integrity

Use of Povidone Iodine Vaginal Swabbing in Treatment of Recurrent Vulvovaginal Candidiasis

Silver secnidazole nano‐hybrid emulsion‐based probiotics as a novel antifungal formula against multidrug‐resistant vaginal pathogens

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