Comparative gene expression profiles of intestinal transporters in mice, rats and humans

Species-Dependent Uptake of Glycylsarcosine but Not Oseltamivir in Pichia pastoris Expressing the Rat, Mouse, and Human Intestinal Peptide Transporter PEPT1

“…Still, it appears that differences may exist in the levels of gene expression among these species. In this regard, human and mouse, but not rat, had comparable levels of PEPT1 mRNA expression in duodenal samples (Kim et al, 2007). In kidney samples, PEPT1 mRNA was moderately expressed in rat with very low expression levels in mouse (Lu and Klaassen, 2006).…”

Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type andPept1Knockout Mice

“…Immunolocalization studies further place PEPT1 at the apical membrane of small intestine (i.e., duodenum, jejunum, and ileum), with little or no expression in the colon of humans and mice (Walker et al, 1998;Groneberg et al, 2001;Ford et al, 2003). Finally, gene expression studies show that both species have comparative intestinal expression patterns and levels, unlike that of the rat (Kim et al, 2007;RubioAliaga and Daniel, 2008).…”

Regulation of the fructose transporter GLUT5 in health and disease

“…The small intestine regulates fructose absorption from dietary sources and, therefore, the availability of fructose to other tissues. It is also the organ system expressing the greatest amount of GLUT5 in human (13,20,47,79,81), rat (24, 35-38, 45, 72, 75, 84, 108, 112, 113, 139, 140, 147), mouse (22,33,83,107), rabbit (109), chicken (60), and horse (104). In cattle, GLUT5 expression in the intestine is significantly lower than in skeletal muscle (159), probably because this species is a foregut fermenter, and it is possible that fructose-like cellulose and other carbohydrate products are fermented in the stomach and little sugar reaches the intestinal lumen.…”