Comparative Genomics Analysis and Outer Membrane Vesicle-Mediated Horizontal Antibiotic-Resistance Gene Transfer in Avibacterium paragallinarum

Xu, Jie; Chen, Mei; Zhi, Yan; Liang, Zhi-Xuan; Zhang, Xue; Wang, Hong-Jun

doi:10.1128/spectrum.01379-22

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…This will require collecting a large amount of data on the drug-resistance of bacteria ( Hsu et al, 2007 ). Research conducted using A. paragallinarum strains obtained from chickens has shown a progressive increase in resistance to a wide range of antimicrobial agents ( Xu et al, 2022 ). Recently, A. paragallinarum isolates have developed resistance to several antimicrobial drugs, such as streptomycin and sulfonamides ( Heuvelink et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China

Cao,

Huang,

Lin

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China

Cao,

Huang,

Lin

et al. 2024

Poultry Science

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“…The MIC of the transformed cells did not increase compared with the susceptible strain Modesto, although the PCR results confirmed that those colonies had amplification match ARG products. As assumed by the authors, this phenomenon was associated with a low gene recombination, where the ARGs were not integrated in the chromosomes, leading to a limited persistency of the transformation in the receiving strain [71]. These results differ from those illustrated by Chen et al, who revealed that the OMVs of a carbapenemase-2-producing K. pneumoniae (KP-R1) might induce a stable resistance in an antibiotic-susceptible strain of K. pneumoniae, and this acquired property was maintained after the third generation [65].…”

Section: Omv-mediated Horizontal Gene Transfermentioning

confidence: 94%

Latest Update on Outer Membrane Vesicles and Their Role in Horizontal Gene Transfer: A Mini-Review

Marinacci,

Krzyżek,

Pellegrini

et al. 2023

Membranes

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Outer membrane vesicles (OMVs) are spherical, lipid-based nano-structures, which are released by Gram-negative bacteria in both in vitro and in vivo conditions. The size and composition of OMVs depend on not only the producer bacterial species but also cells belonging to the same strain. The mechanism of vesicles’ biogenesis has a key role in determining their cargo and the pattern of macromolecules exposed on their surface. Thus, the content of proteins, lipids, nucleic acids, and other biomolecules defines the properties of OMVs and their beneficial or harmful effects on human health. Many studies have provided evidence that OMVs can be involved in a plethora of biological processes, including cell-to-cell communication and bacteria–host interactions. Moreover, there is a growing body of literature supporting their role in horizontal gene transfer (HGT). During this process, OMVs can facilitate the spreading of genes involved in metabolic pathways, virulence, and antibiotic resistance, guaranteeing bacterial proliferation and survival. For this reason, a deeper understanding of this new mechanism of genetic transfer could improve the development of more efficient strategies to counteract infections sustained by Gram-negative bacteria. In line with this, the main aim of this mini-review is to summarize the latest evidence concerning the involvement of OMVs in HGT.

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“…Moreover, it should be noted that not every EV-mediated transfer of resistance genes can stably induce a resistant phenotype. For example, Xu and colleagues [ 62 ] co-cultured EVs from Avibacterium paragallinarum P4chr1, which carried resistance genes, with the susceptible strain A . paragallinarum Modesto.…”

Section: Bacterial Evs Contribute To Antimicrobial Resistancementioning

confidence: 99%

Microbial extracellular vesicles contribute to antimicrobial resistance

Jiang,

Lai,

Xiao

et al. 2024

PLoS Pathog

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With the escalating global antimicrobial resistance crisis, there is an urgent need for innovative strategies against drug-resistant microbes. Accumulating evidence indicates microbial extracellular vesicles (EVs) contribute to antimicrobial resistance. Therefore, comprehensively elucidating the roles and mechanisms of microbial EVs in conferring resistance could provide new perspectives and avenues for novel antimicrobial approaches. In this review, we systematically examine current research on antimicrobial resistance involving bacterial, fungal, and parasitic EVs, delineating the mechanisms whereby microbial EVs promote resistance. Finally, we discuss the application of bacterial EVs in antimicrobial therapy.

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Comparative Genomics Analysis and Outer Membrane Vesicle-Mediated Horizontal Antibiotic-Resistance Gene Transfer in Avibacterium paragallinarum

Abstract: The functions and roles of OMVs on ARG and virulent gene transfer and dissemination have been reported in numerous Gram-negative bacteria. However, the role of OMVs in mediating antibiotic resistance in A. paragallinarum has not been reported.

Cited by 8 publications

References 31 publications

Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China

Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China

Latest Update on Outer Membrane Vesicles and Their Role in Horizontal Gene Transfer: A Mini-Review

Microbial extracellular vesicles contribute to antimicrobial resistance

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