2004
DOI: 10.1101/gr.1524804
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Comparative Genomics of Gene Expression in the Parasitic and Free-Living Nematodes Strongyloides stercoralis and Caenorhabditis elegans

Abstract: Although developmental timing of gene expression is used to infer potential gene function, studies have yet to correlate this information between species. We analyzed 10,921 ESTs in 3311 clusters from first-and infective third-stage larva (L1, L3i) of the parasitic nematode Strongyloides stercoralis and compared the results to Caenorhabditis elegans, a species that has an L3i-like dauer stage. In the comparison of S. stercoralis clusters with stage-specific expression to C. elegans homologs expressed in either… Show more

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Cited by 92 publications
(105 citation statements)
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“…3). Of all P. penetrans clusters with homologies, the majority (62.6%) matched sequences in all three databases, as has been observed in previous studies (McCarter et al 2003a;Mitreva et al 2004). Many gene products in this category are conserved across metazoans, and are involved in core biological processes.…”
Section: Functional Classification Based On Gene Ontology and Kegg Assupporting
confidence: 57%
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“…3). Of all P. penetrans clusters with homologies, the majority (62.6%) matched sequences in all three databases, as has been observed in previous studies (McCarter et al 2003a;Mitreva et al 2004). Many gene products in this category are conserved across metazoans, and are involved in core biological processes.…”
Section: Functional Classification Based On Gene Ontology and Kegg Assupporting
confidence: 57%
“…Many gene products in this category are conserved across metazoans, and are involved in core biological processes. In contrast to our prior studies of M. incognita (McCarter et al 2003a) and S. stercoralis (Mitreva et al 2004), the C. elegans genome alone was no longer the best source for P. penetrans sequence homologies (78.9%), as 95.5% of the clusters matched nematode sequences from species other than C. elegans. The prominence of matches to Fig.…”
Section: Functional Classification Based On Gene Ontology and Kegg Ascontrasting
confidence: 51%
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