Comparative immunologic studies with salivary and epithelial extracts of the dog, cat, and rabbit

Spain, W.C.; Gillson, Reginald E.; Strauss, Margaret B.

doi:10.1016/s0021-8707(42)90069-8

Cited by 17 publications

(4 citation statements)

References 5 publications

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“…dander has been shown with many animals. Allergens have been found in serum (6,16,19, Crossed line radioimmunoelectrophoresis was per-21, 22, 28), saliva (10,25), urine (7) and brain formed on St.C-75 against rabbit anti-cow hair (20). Recently, the importance of saliva as and dander with "line gels" containing extracts source of allergens has been stressed (10).…”

Section: Sheep and Goatmentioning

confidence: 99%

Allergens in Cow Hair and Dander

Prahl

1981

Allergy

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Quantitative immunoelectrophoretic methods were used for the analysis of the allergens in cow hair and dander and for comparison with related preparations. The immunoelectrophoretic precipitation pattern of an extract from cow hair and dander showed 17 precipitates. Crossed radioimmunoelectrophoresis showed four of these to be major allergens of the extract, and these allergens are common major allergens in four investigated cow breeds. The allergens are associated predominantly with hair and dander, but they were also demonstrated in cow saliva, urine, whey, amniotic fluid and beef, as well as in cow-hide products. Allergens displaying partial immunological identity with the major allergens of cow hair and dander were found in extracts from goat and sheep pelts, in products made of these materials such as carpet and knitting wool, and in carpets made of animal hair.

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Section: Sheep and Goatmentioning

confidence: 99%

Allergens in Cow Hair and Dander

Prahl

1981

Allergy

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“…As early as 1942, Spain et al [19] demonstrated that the specific antibody activity in the sera of cat allergic subjects could be neutralized by saliva as well as pelt extract. In 1978, the allergenic activity of feline saliva was confirmed in the preliminary report of Karpas and Baer [l], and later by other investigators [4,5], Ac cording to these studies, the allergenic activity of cat saliva was so extensive that saliva could be considered as the main source of the allergenicity of cats [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Also Lutsky et al [II] found evidence of allergenic activity in dog urine: 80% of dog-allergic atopic subjects gave a positive skin test reaction to dog urine. There are no reports of the allergenicity of dog saliva since the pioneering studies of Spain et al [ 19].…”

Section: Introductionmentioning

confidence: 99%

Cross-Reactivity of Cat and Dog Allergen Extracts

Viander

Valovirta

Vanto

et al. 1983

Int Arch Allergy Immunol

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The commercial cat and dog allergen extracts are traditionally prepared from pelt, fur or dander. However, there is increased evidence of the allergenicity of saliva and urine of the animals. We have investigated 25 asthmatic children with a positive cat and/or dog RAST result. All 20 subjects with a positive cat RAST gave a positive skin prick test result to cat saliva, cat urine and cat hair. Analogously, all 20 subjects with a positive dog RAST had a positive skin reaction to dog saliva, urine and dander. In RAST inhibition experiments with dog and cat allergen discs, dog saliva appeared to be at least as potent as a commercial dog dander and hair extract, while cat saliva was less potent than the respective commercial extract. Both dog and cat salivas were clearly more potent than the respective urine. Significant cross-reactivity was observed between cat hair and dog dander in the RAST inhibition, whereas saliva and urine were shown to be more species-specific. An experimental dog dander preparation had about the same specificity as, and even higher allergenic activity than, that of dog saliva or urine. Our results suggest that saliva actually may be the best source of cat and dog allergen preparations. The importance of urine warrants further investigation.

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“…No difference could be demonstrated between the other six extracts (European shorthair, Chestnut brown, Persian, Color point long hair, Manxhair and Abyssinian). Spain et al [1942] pointed out that individuals sensitive to animals exhibit local reactions when licked or mouthed by pets. They were able to show the presence of a common allergen in cat saliva and cat epithelia extracts.…”

mentioning

confidence: 99%

The Allergens of Cat Epithelia and Cat Serum

Brandt¹,

Ponterius²,

Yman³

1973

Int Arch Allergy Immunol

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Cat epithelia extracts were found to contain several electrophoretically separable allergens. Some of these were also detected in cat serum. In addition to serum proteins the epithelia extracts contain allergens with higher electrophoretic mobility than albumin, which was found to be the main allergen of cat serum. The molecular weight of the main cat epithelia allergen was about 32,000. 56 sera from allergic patients were studied by means of the radioallergosorbent test using cat epithelia extracts, a purified epithelia allergen fraction and cat serum as test allergens. About 7% of the patient sera were found to contain IgE specific to cat serum proteins. IgE specific to the epithelia allergen fraction, which was free from serum proteins, was found in 66% of the patient sera, while the rest, about 27%, contained IgE reacting with both kinds of allergens.

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Comparative immunologic studies with salivary and epithelial extracts of the dog, cat, and rabbit

Cited by 17 publications

References 5 publications

Allergens in Cow Hair and Dander

Allergens in Cow Hair and Dander

Cross-Reactivity of Cat and Dog Allergen Extracts

The Allergens of Cat Epithelia and Cat Serum

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