Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, HR 810 (a new cephalosporin), RU28965 (a new macrolide), and other agents against enteropathogens

Goossens, Herman; Mol, Patrick De; Coignau, H; Levy, Jack S.; Grados, O; Ghysels, G; Innocent, H; Butzler, Jean‐Paul

doi:10.1128/aac.27.3.388

Cited by 89 publications

(31 citation statements)

References 24 publications

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“…This was reported previously in C. jejuni strains by Goossens et al (1985) and by our group (Tejero et al 1996) We have previously found a low percentage (2.3%) of tetracycline resistance in strains isolated from hens (Tejero et al 1996), and in the present study only two (1.8%) out of the 108 clinical strains tested were resistant to this antibiotic. So, based on the evidence mentioned above, we can conclude that in this geographical region tetracycline is not yet a problem as it is in other countries (Taylor & Courvalin 1988, Gaudreau & Gilbert 1998, Li et al 1998.…”

supporting

confidence: 40%

Antimicrobial susceptibility of Campylobacter jejuni subsp. jejuni assessed by E-test and double dilution agar method in Southern Chile

Fernández

Mansilla

González

2000

Mem. Inst. Oswaldo Cruz

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Campylobacter jejuni subsp. jejuni is one of the most frequent causes of infectious diarrhea in both, developed and developing countries (Fernández 1992, Allos & Blaser 1995. Although C. jejuni subsp. jejuni diarrhea is a self-limited disease, in some clinical instances it is necessary the prescription of antibiotics, being erythromycin the drug of choice (Allos & Blaser 1995). For several years however, higher levels of resistance to this drug, as well as to others, such as tetracycline and fluoroquinolones, have been reported in several countries (Taylor & Courvalin 1988).The information on bacteriological, biological, pathogenical, clinical and epidemiological aspects of C. jejuni subsp. jejuni generated in South America is vast and valuable (Fernández 1992). However, the susceptibility patterns of this bacterium have not been well defined in this geographical region.The aim of this study was to determine the susceptibility patterns of C. jejuni subsp. jejuni clinical strains, to six antimicrobial agents, in Southern Chile by using two quantitative methods.A total of 108 C. jejuni subsp. jejuni strains submitted in this study, had been isolated and identified from pediatric diarrheic stools specimens using standard procedures between March 1996 and December 1997. Strains were stored at -35ºC in freezing medium until analyzed. Staphylococcus aureus ATCC 25923 and Escherichia coli and E. coli ATCC 25922 were used as control strains.The antimicrobial susceptibility patterns of the strains under study were determined by means of the E-test and the double dilution agar method (Baker et al. 1991).To perform the E-test, several colonies of each strain, obtained from a fresh culture in blood agar plate, were suspended in 5 ml of Mueller-Hinton broth to achieve a turbidity equal to the 0.5 Mac Farland standard. The suspensions were inoculated with sterile swabs onto 150 mm diameter MuellerHinton 5% sheep blood agar plates and after the agar surfaces were allowed to dry, six E-test strips were applied on each plate. Plates were incubated at 37ºC for 48 h under microaerobic conditions and inhibitory concentrations were read at the point where the elliptical zone of inhibition intersected the E-test strip.For the agar dilution method, Mueller-Hinton agar plates containing serial twofold dilutions of each antimicrobial agent from 0.125 to 128 µg/ ml were prepared. Inocula of the strains were prepared diluting 1:10 each bacterial suspension made in Mueller-Hinton broth with a turbidity equal to the 0.5 Mac Farland standard. Plates were inoculated with a multipoint replicator delivering spots of 4This work received financial support from grants S-97-21 DID-UACH and FONDECYT 1980920. + Corresponding

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supporting

confidence: 40%

Antimicrobial susceptibility of Campylobacter jejuni subsp. jejuni assessed by E-test and double dilution agar method in Southern Chile

Fernández

Mansilla

González

2000

Mem. Inst. Oswaldo Cruz

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“…Little is known about the ,B-lactam susceptibility pattern of C. coli. A few studies have reported data about ampicillin (4,12,14), amoxicillin (6,14), cefotaxime (4,6,15), cephalothin (4,10,15), cefoperazone (14), and cefuroxime and penicillin G (15) susceptibility. ,B-Lactamase production was reported in 29 of 31 C coli tested by Fliegelman et al (4).…”

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confidence: 99%

Susceptibilities of beta-lactamase-positive and -negative strains of Campylobacter coli to beta-lactam agents

Lachance

Gaudreau

Lamothe

et al. 1993

Antimicrob Agents Chemother

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The percentages of susceptibility of 28 strains of Campylobacter coli to 1-lactam agents were 96% for amoxicillin and ampicillin, 57% for ticarcillin, 4% for cefoxitin and cefuroxime, 61% for cefotaxime, and 11% for ceftazidime. None of the strains were susceptible to penicillin G, piperacillin, cefazolin, cephalothin, cefamandole, and cefoperazone. All strains were susceptible to imipenem and ciprofloxacin, and 21% were susceptible to erythromycin. A 13-lactamase was detected in 68% of the strains by cefinase disks and by the nitrocefin method. The 13-lactamase-positive strains were significantly less susceptible to amoxicillin, ampicillin, and ticarcillin than the 13-lactamase-negative strains (P < 0.003). Clavulanic acid (0.25 ,ug/ml) but not sulbactam and tazobactam (2 jg/ml) lowered to susceptible levels the amoxicillin and ampicillin MICs of the only strain of C. coli resistant to amoxicillin, ampicillin, and ticarcillin.Campylobacter coli has been recognized as a cause of human bacterial diarrhea and represents between 3 and 7% of Campylobacter human infections (1,8). Little is known about the ,B-lactam susceptibility pattern of C. coli. A few studies have reported data about ampicillin (4,12,14), amoxicillin (6, 14), cefotaxime (4, 6, 15), cephalothin (4, 10, 15), cefoperazone (14), and cefuroxime and penicillin G (15) susceptibility. ,B-Lactamase production was reported in 29 of 31 C coli tested by Fliegelman et al. (4). The purpose of this study was to determine the susceptibility pattern of C. coli to 3-lactam agents and to investigate the role of the ,-lactamase in the resistance to these antibiotics. The effect of clavulanic acid, sulbactam, and tazobactam on amoxicillin, ampicillin and ticarcillin was also studied.Ten strains of C. coli were obtained from a collection of 160 human thermophilic Campylobacter strains isolated in five hospitals in the Montreal area. Eighteen other human strains of C coli were obtained from the Laboratoire de Sante Publique du Quebec. Identification was done by the methods of the Centers for Disease Control, Atlanta, Ga. (8)

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“…For presumptive therapy, the quinolone class of antimicrobial agents offers the advantage of marked bactericidal activity against pathogens of bacterial enteritis, including Campylobacter spp., enterotoxigenic Escherichia coli, and Vibrio spp. (7,14). Tosufloxacin (T-3262; A-60969 HCl; A-61827 tosylate) has improved activity compared with other quinolones against gram-positive cocci and anaerobic organisms (4,6), as well as Listeria monocytogenes (4).…”

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confidence: 99%

In vitro activities of tosufloxacin, temafloxacin, and A-56620 against pathogens of diarrhea

Bryan

Waters

Sheffield

et al. 1990

Antimicrob Agents Chemother

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Tosufloxacin (A-60969 HCl), a new quinolone with broad activity against gram-positive and anaerobic organisms, was compared in vitro with other quinolones against bacterial pathogens of diarrhea. Tosufloxacin was the most active agent against Salmonella spp., Shigella spp., Campylobacter spp., Aeromonas hydrophila, and Vibrio spp. Temafloxacin (A-62254) also demonstrated good activity against these organisms.

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Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, HR 810 (a new cephalosporin), RU28965 (a new macrolide), and other agents against enteropathogens

Cited by 89 publications

References 24 publications

Antimicrobial susceptibility of Campylobacter jejuni subsp. jejuni assessed by E-test and double dilution agar method in Southern Chile

Antimicrobial susceptibility of Campylobacter jejuni subsp. jejuni assessed by E-test and double dilution agar method in Southern Chile

Susceptibilities of beta-lactamase-positive and -negative strains of Campylobacter coli to beta-lactam agents

In vitro activities of tosufloxacin, temafloxacin, and A-56620 against pathogens of diarrhea

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