2019
DOI: 10.20473/j.djmkg.v52.i1.p36-40
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Comparative in vitro study of the cytotoxicity of gelatine and alginate to human umbilical cord mesenchymal stem cells

Abstract: Background: Mesenchymal stem cells (MSCs) and scaffold combination constitute a promising approach currently adopted for tissue engineering. Umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are easily obtained and non-invasive. Gelatine and alginate constitute a biocompatible natural polymer scaffold. At present, a cytotoxicity comparison of gelatine and alginate to hUC-MSCs is not widely conducted Purpose: This study aimed to compare the cytotoxicity of gelatine and alginate in hUC-MSCs in vitro. Meth… Show more

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Cited by 4 publications
(4 citation statements)
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“…[32][33][34][35] Alginate is another natural hydrogel which is extensively used in bioprinting in general [36][37][38][39][40][41] and in cartilage engineering in particular. [39,[42][43][44] That is because it is non-toxic, [45,46] low-immunogenic, [47] and can gelate into a 3D structure upon exposure to Ca 2+ ions. [48,49] Here, we report an advanced 4D biofabrication method based on the differential swelling of a multi-material smart hydrogelbased bioink, with a special focus on cartilage TE.…”
Section: Introductionmentioning
confidence: 99%
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“…[32][33][34][35] Alginate is another natural hydrogel which is extensively used in bioprinting in general [36][37][38][39][40][41] and in cartilage engineering in particular. [39,[42][43][44] That is because it is non-toxic, [45,46] low-immunogenic, [47] and can gelate into a 3D structure upon exposure to Ca 2+ ions. [48,49] Here, we report an advanced 4D biofabrication method based on the differential swelling of a multi-material smart hydrogelbased bioink, with a special focus on cartilage TE.…”
Section: Introductionmentioning
confidence: 99%
“…[ 32–35 ] Alginate is another natural hydrogel which is extensively used in bioprinting in general [ 36–41 ] and in cartilage engineering in particular. [ 39,42–44 ] That is because it is non‐toxic, [ 45,46 ] low‐immunogenic, [ 47 ] and can gelate into a 3D structure upon exposure to Ca 2+ ions. [ 48,49 ]…”
Section: Introductionmentioning
confidence: 99%
“…There is a higher interest in searching the prospects of human umbilical cord mesenchymal stem cells (HUCMSC) because this stem cell can be isolated and expanded easily in large quantities, and non-invasive compared to commonly used bone marrow mesenchymal stem cells [18]. There are studies about other MSC sources, but little information was available regarding HUCMSC and its potential use in pulpal and periapical regeneration.…”
Section: Discussionmentioning
confidence: 99%
“…Although human bone marrow mesenchymal stem cells are more popular, there are disadvantages, such as the requirement of general anesthesia regarding the invasive surgical procedure involved, and multiple procedures may be needed to acquire a sufficient number of cells [10]. Human umbilical cord mesenchymal stem cells (HUCMSC) are used in this study because they can be isolated and expanded easily in large quantities in vitro [2].…”
Section: Discussionmentioning
confidence: 99%