Comparative isoconversional thermal analysis of <i>Artemisia vulgaris</i> hydrogel and its acetates; a potential matrix for sustained drug delivery

Farid-ul-Haq, Muhammad; Amin, Muhammad; Hussain, Muhammad Ajaz; Sher, Muhammad; Khan, Taskin Aman; Kausar, Fahmeeda; Amin, Hatem M. A.

doi:10.1080/1023666x.2020.1819085

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…From Figure 14 and Figure 15 and Table 2 , it can be seen that gel 1 and gel 2 showed two significant weight losses, while gel 3 and gel 4 showed almost one weight loss. This shows that the thermal stability of gel 3 and gel 4 is higher than that of gel 1 and gel 2 [ 43 , 53 ]. This is because the higher the degree of polymerization, the more hydrogen bonding, the stronger the force and the higher the relative weight loss temperature [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Stereo-Complex and Click-Chemical Bicrosslinked Amphiphilic Network Gels with Temperature/pH Response

Yang

Wang

Jia

et al. 2023

Gels

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Stimulus-responsive hydrogels have been widely used in the field of drug delivery because of their three-dimensional pore size and the ability to change the drug release rate with the change in external environment. In this paper, the temperature-sensitive monomer 2-methyl-2-acrylate-2-(2-methoxyethoxy-ethyl) ethyl ester (MEO2MA) and oligoethylene glycol methyl ether methacrylate (OEGMA) as well as the pH-sensitive monomer N,N-Diethylaminoethyl methacrylate (DEAEMA) were used to make the gel with temperature and pH response. Four kinds of physicochemical double-crosslinked amphiphilic co-network gels with different polymerization degrees were prepared by the one-pot method using the stereocomplex between polylactic acid as physical crosslinking and click chemistry as chemical crosslinking. By testing morphology, swelling, thermal stability and mechanical properties, the properties of the four hydrogels were compared. Finally, the drug release rate of the four gels was tested by UV–Vis spectrophotometer. It was found that the synthetic hydrogels had a good drug release rate and targeting, and had great application prospect in drug delivery.

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Section: Resultsmentioning

confidence: 99%

Stereo-Complex and Click-Chemical Bicrosslinked Amphiphilic Network Gels with Temperature/pH Response

Yang

Wang

Jia

et al. 2023

Gels

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“…Therefore these multistep processes occur at different E a values relative to α . [ 18 ] The following equation (Equation (2)) was generally believed that this equation can only be applied to one α value, so that single step equation with several specific alpha values was used to determine the kinetics process of degradation.

\begin{equation}\frac{{d\alpha }}{{dT}} = A{e^{\frac{{ - {E_a}}}{{RT}}}}f(\alpha )\end{equation}

…”

Section: Methodsmentioning

confidence: 99%

“…Definite thermal and kinetic parameters were determined through Flynn–Wall–Ozawa (FWO) and Kissinger methods. [ 18 ] Significant kinetic of degradation were determined by model free linear integral technique FWO. The FWO whose non‐graphical shape was given below as Equation (3):

\begin{equation} ln\beta = \frac{{\ln A{E_\alpha }}}{{Rg(x)}} - 5.331 - 1.052\frac{{{E_a}}}{{RT}}\;\end{equation}

where, β represented the heating rate, A was a pre‐exponential factor, E a was the activation energy, R was a general gas constant, T was the absolute temperature at the conversion rate ( α ).…”

Section: Methodsmentioning

confidence: 99%

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Synthesis, Characterization, Isoconversional Analysis and Degradation Kinetics of Novel Acetate Coated Hydroxyethyl Starch: A New Candidate as a Drug Carrier

Abbas

Rizwan

et al. 2022

Starch Stärke

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The hydroxethyl starch (HES) is very trending biopolymer in biomedical field.In recent research we have successfully synthesized a novel ester of HES, i.e., HES-acetate by acetylation of HES followed by investigation of its thermal behavior. The successful acetylation of HES was confirmed by Fourier Transform Infrared (FTIR) and Proton-Nuclear Magnetic Resonance (1H NMR) spectroscopic techniques. Thermal stability and thermal degradation kinetics of HES-acetate were investigated by thermo-gravimetric analysis. Flynn-Waal-Ozawa model was fitted to the thermal data to find the values of thermodynamic triplet (𝚫S, 𝚫G and 𝚫E). Energy of activation (Ea) values of the major thermal degradation steps were found to be 242.85 and 287.17 kJ mol -1 for HES and HES-acetate, respectively. The order of degradation, integral procedural decomposition temperature (IPDT) and index of intrinsic thermal stability (ITS) were also taken into account. The results of the thermal analysis reveal that the HES-acetate gained significant thermal stability as compared to that of HES. This benign polysaccharide-based material was investigated for its potential in drug release studies by taking caffeine as a model drug. HES-acetate-based matrix tablets showed sustained release behavior of the drug indicating its potential for the development of oral delivery systems for sustained drug release.

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“…Isoconversional methods of thermal analysis are based on assuming that the reaction model remains independent of the degree of conversion. Two methods were used in the current work: [33] Kissinger-Akahira-Sunose (KAS, equation (5)) and Flynn-Wall-Ozawa (FWO, equation (6)).…”

Section: Thermal Analysismentioning

confidence: 99%

The model pH-controlled delivery system based on gelatin-tannin hydrogels containing ferrous ascorbate: iron release in vitro

Osetrov¹,

Olekhnovich²,

Uspenskaya³

2023

Biomed. Phys. Eng. Express

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Hydrogels became an essential class among all biomaterials. Specialized biomaterials are highly appreciated in the field of biomedical applications. One of problem in wound management is a local deficiency of microelements related to extensive wound lesions. The significant absence of an elemental iron in human body leads to serious consequences and prolongation of treatment. The synthesis of gelatin-tannin hydrogels with ion delivery function is proposed in this study. The ability to release ions in low acidity solution is a sphere of great interest. pH downing in wound cavity usually concerns with contamination of some bacterial cultures. pH-controlled delivery of iron in buffer solutions (рН=5.5/6.4/7.4) was considered for these hydrogels. The kinetic of iron release was determined by visible spectroscopy. Theoretical models were applied to describe process of ion delivery. The structure of materials was examined by IR-spectroscopy and demonstrated incorporation of ferrous ascorbate in hydrogel matrix. Thermal analysis was used to pointed the key differences in thermal behavior by isoconversional methods (Flynn-Wall-Ozawa/Kissinger-Akahira-Sunose). Mechanical characteristics of materials were studied. The effect of iron ascorbate on polymer network parameters was discussed. Current study showed a possibility of obtaining gelatin-tannin hydrogels for pH-dependent iron delivery. That provides future perspectives to expand the set of releasing microelements for biomedical applications.

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Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery

Cited by 6 publications

References 14 publications

Stereo-Complex and Click-Chemical Bicrosslinked Amphiphilic Network Gels with Temperature/pH Response

Stereo-Complex and Click-Chemical Bicrosslinked Amphiphilic Network Gels with Temperature/pH Response

Synthesis, Characterization, Isoconversional Analysis and Degradation Kinetics of Novel Acetate Coated Hydroxyethyl Starch: A New Candidate as a Drug Carrier

The model pH-controlled delivery system based on gelatin-tannin hydrogels containing ferrous ascorbate: iron release in vitro

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