Comparative metabolic profiles of total and partial body radiation exposure in mice using an untargeted metabolomics approach

Maan, Kiran; Tyagi, Rajeev K.; Dutta, A.; Bakhshi, Radhika; Rana, Poonam

doi:10.1007/s11306-020-01742-7

Cited by 17 publications

(19 citation statements)

References 41 publications

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“…The importance of these metabolites in radiation studies is however known but this combined analysis further reconfirms their significance and also substantiates our recent previous findings. 5,8,12–15,39,40…”

Section: Discussionmentioning

confidence: 99%

“…A few of the mechanisms involved in post-radiation exposure are well explained in our recent study. 15…”

Section: Discussionmentioning

confidence: 99%

“…Radiation metabolomics has utilized both 1 H NMR and LC-MS techniques to identify radiation induced changes. 8,10–15 Many of these studies have also demonstrated a dose correlation between the level of the expressed biomarker and received radiation dose in murine and nonhuman primate models. 10,11,16–18 Our recent study has also shown a proof of concept on developing a prediction model for radiation exposure based on metabolite biomarkers.…”

Section: Introductionmentioning

confidence: 99%

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An integrative chemometric approach and correlative metabolite networking of LC-MS and ¹H NMR based urine metabolomics for radiation signatures

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…A few of the mechanisms involved in post-radiation exposure are well explained in our recent study. 15…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An integrative chemometric approach and correlative metabolite networking of LC-MS and ¹H NMR based urine metabolomics for radiation signatures

et al. 2022

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“…Very recent studies on radiation biodosimetry report that it is possible to distinguish the metabolic changes in blood and urine due to a partial-and total-body irradiation of animals and humans [17,18]. However, in case of tumors of a similar stage and location, e.g., in the locally advanced head and neck cancers, the irradiated volumes differ only slightly.…”

Section: Introductionmentioning

confidence: 99%

NMR-Based Metabolomics in Investigation of the Radiation Induced Changes in Blood Serum of Head and Neck Cancer Patients and Its Correlation with the Tissue Volumes Exposed to the Particulate Doses

Boguszewicz

Bieleń

Ciszek

et al. 2021

IJMS

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In the present study, we analyze the nuclear magnetic resonance (NMR) blood serum metabolic profiles of 106 head and neck squamous cell carcinoma (HNSCC) patients during radio (RT) and concurrent radio-chemotherapy (CHRT). Four different fractionation schemes were compared. The blood samples were collected weekly, from the day before the treatment until the last week of CHRT/RT. The NMR spectra were acquired on A Bruker 400 MHz spectrometer at 310 K and analyzed using multivariate methods. Seven metabolites were found significantly to be altered solely by radiotherapy: N-acetyl-glycoprotein (NAG), N-acetylcysteine, glycerol, glycolate and the lipids at 0.9, 1.3 and 3.2 ppm. The NMR results were correlated with the tissue volumes receiving a particular dose of radiation. The influence of the irradiated volume on the metabolic profile is weak and mainly limited to sparse correlations with the inflammatory markers, creatinine and the lymphocyte count in RT and the branched-chain amino-acids in CHRT. This is probably due to the optimal planning and delivery of radiotherapy improving sparing of the surrounding normal tissues and minimizing the differences between the patients (caused by the tumor location and size).

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“…Different biomarkers quantified in various biofluids have been proposed: microRNAs, metabolites, or proteins. [77][78][79][80][81] This strategy assumes that the individual's susceptibility might change over time and repeated testing may identify current, rather than genetically predetermined, susceptibility before starting treatment or during the course of RT. The principle of these tests relies on the manifestation of a cellular damage signal in the biofluids due to irradiation, and correlating the intensity of the signal with the incurred damage or a specific outcome after treatment.…”

Section: Primary Prevention Of Radiation Pneumonitismentioning

confidence: 99%

The clinician’s guide to radiotherapy complications

Fendler¹,

Tomasik²,

Atkins³

et al. 2022

Polish Archives of Internal Medicine

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effects of radiotherapy 1 is not limited to tumor cells. However, as the effects of radiotherapy are local or locoregional, the histologic properties of irradiated tissues influence the clinical presentation of toxicity. Organs in the human body consist of functional units and, based on their arrangement, they can be classified either as parallel (eg, the lungs) or serial (eg, the esophagus). 3 For parallel organs, the percentage of irradiated volume and mean dose are the dose -limiting factors. Conversely, serial organs cannot tolerate excessive doses even to very small areas because the damage of just one segment can affect the function of the whole organ.Introduction Radiation therapy (RT) is an essential modality of cancer treatment and is used with curative or palliative intent in more than half of cancer patients. 1 External beam radiotherapy (EBRT) is the most common type of RT, typically using a linear accelerator to deliver treatment. Brachytherapy (BT), the other major form of RT, is performed by direct insertion of the radioactive source into the body to deliver the dose in close proximity to a malignant lesion. The latter method spares a greater amount of normal tissues from dose exposure, but requires an invasive procedure. 2 The mechanism of cell killing from radiation is similar, regardless of the modality used, and

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Comparative metabolic profiles of total and partial body radiation exposure in mice using an untargeted metabolomics approach

Cited by 17 publications

References 41 publications

An integrative chemometric approach and correlative metabolite networking of LC-MS and ¹H NMR based urine metabolomics for radiation signatures

An integrative chemometric approach and correlative metabolite networking of LC-MS and ¹H NMR based urine metabolomics for radiation signatures

NMR-Based Metabolomics in Investigation of the Radiation Induced Changes in Blood Serum of Head and Neck Cancer Patients and Its Correlation with the Tissue Volumes Exposed to the Particulate Doses

The clinician’s guide to radiotherapy complications

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Comparative metabolic profiles of total and partial body radiation exposure in mice using an untargeted metabolomics approach

Cited by 17 publications

References 41 publications

An integrative chemometric approach and correlative metabolite networking of LC-MS and 1H NMR based urine metabolomics for radiation signatures

An integrative chemometric approach and correlative metabolite networking of LC-MS and 1H NMR based urine metabolomics for radiation signatures

NMR-Based Metabolomics in Investigation of the Radiation Induced Changes in Blood Serum of Head and Neck Cancer Patients and Its Correlation with the Tissue Volumes Exposed to the Particulate Doses

The clinician’s guide to radiotherapy complications

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An integrative chemometric approach and correlative metabolite networking of LC-MS and ¹H NMR based urine metabolomics for radiation signatures

An integrative chemometric approach and correlative metabolite networking of LC-MS and ¹H NMR based urine metabolomics for radiation signatures