Comparative Palynological, Physicochemical, Antioxidant and Antibacterial Properties of Romanian Honey Varieties for Biomedical Applications

Iosăgeanu, Andreea; Mihai, Elena; Prelipcean, Ana-Maria; Anton, Ruxandra Elena; Uțoiu, Elena; Oancea, Anca; Crăciunescu, Oana; Cîmpean, Anișoara

doi:10.1002/cbdv.202200406

Cited by 6 publications

(4 citation statements)

References 59 publications

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“…Accordingly, a wide range of nectar and pollen producing plants were distributed in Iran which has led to the production of about 55 different types of mono-floral and polyfloral honey in Iran 45 , a wide range of which are classified as medical food and medical grades 46 . Melissopalynology is considered as an effective method of identifying and determining the abundance of plants selected by honey bees, which, along with measuring the antioxidant activity of honey, can determine the effect of plants on the antioxidant activity of honey 47 , 48 . In this study, to determine the frequency of the presence of plant families of the antioxidant activity of honey, the method of melissopalynology and the laboratory measurement of the antioxidant activity of honeys produced in the Zagros and Alborz Mountains were used.…”

Section: Introductionmentioning

confidence: 99%

The amount of antioxidants in honey has a strong relationship with the plants selected by honey bees

Shakoori,

Salaseh,

Mehrabian

et al. 2024

Sci Rep

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As one of the main sources of natural antioxidants, flowering plants play a role in the prevention and treatment of many diseases directly and indirectly. Honey is considered as an important nutrient in the supply of natural antioxidants, the amount of which is directly dependent on the plant origin and geographical location of the bee feeding place. The existence of valuable communities of native and endemic plant species has turned Alborz, Zagros and Azerbaijan into the most important hubs of honey production in Iran. In this study, we collected samples of honey from more than 90 regions in Alborz, Zagros and Azerbaijan during the years 2020 to 2021. We evaluated the samples using melissopalynology method and measuring the amount of antioxidant activity. The rise of antioxidant activity in honey is dependent on the abundance of some plant families as well botanical origins. The abundance of plant families Rosaceae, Amaranthaceae, Fabaceae and Asteraceae showed a higher influence on the amount of antioxidants in honey than other plant families. Also, the abundance of plant families Rosaceae and Fabaceae increased with increasing altitude. In general, the amount of antioxidant activity of honey samples shows a different percentage under the influence of ecological and geographical changes.

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Section: Introductionmentioning

confidence: 99%

The amount of antioxidants in honey has a strong relationship with the plants selected by honey bees

Shakoori,

Salaseh,

Mehrabian

et al. 2024

Sci Rep

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“…42 The role of honey in phase II detoxification could be attributed to augmentation of the process of glucuronidation through its content of glucuronic acid. 43 In the infants studied, the levels of glutathione S transferase were not assessed.…”

Section: Discussionmentioning

confidence: 99%

Medical-grade Spore-free Natural Honey is an Effective Choleretic in Neonatal Cholestasis: A Pilot Single-center Trial

Kotb¹,

Satar²,

Badr³

et al. 2023

Gene Expr

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Background and objectives: Liver damage in cholestasis is multifactorial, yet bile acid-mediated hepatotoxicity is pivotal. Honey consumption has many physiological effects; it influences detoxification process (phase I, II and III), has antioxidant, anti-inflammatory, immune-stimulant, anti-ulcer, wound/burn healing effects and others. The bile acid ursodeoxycholic acid (UDCA) is currently used off-label to treat neonatal cholestasis. This study aimed to assess the effectiveness of spore-free natural honey to treat neonatal nonobstructive cholestasis.Methods: Thirty infants with cholestasis received spore-free natural honey. Their progression was compared to a control group with cholestasis (28 infants) and a historical group (31 infants) on UDCA. Results:The mean ± standard deviation (SD) follow-up duration was 29.68 ± 18.68 months. At presentation, the total bilirubin concentrations were 9.5 ± 5.9 mg/dL, 10.9 ± 7 mg/dL and 14 ± 9 mg/dL in the honey, control and UDCA groups, respectively (p = 0.064), and their direct bilirubin concentrations were 6 ± 4 mg/dL, 6.7 ± 4 mg/dL and 8.4 ± 6.9 mg/dL, respectively (p = 0.169). The final total bilirubin concentrations were 1.2 ± 1.7 mg/dL, 4.6 ± 8.2 mg/dL and 7.3 ± 8.9 mg/dL, (p = 0.006), and their final direct bilirubin concentrations were 0.8 ± 1 mg/dL, 2.77 ± 5.2 mg/dL and 5.1 ± 7.2 mg/dL (p = 0.008), with cure achievement in 25, 16 and 16 (p = 0.023), improvement in 3, 5 and 3 (p = 0.565), failure in 2, 3 and 10 (p = 0.016), and death in 0, 4 and 2, respectively (p = 0.095). None suffered from botulism or flaccid paralysis.Conclusions: Spore-free honey is effective in clearing cholestasis in neonates and infants. UDCA use in cholestasis in pediatric age should be abandoned as it is less effective and is associated with a worse outcome.

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“…[37] In addition, antioxidant activities of SHs from Portuguese, Romania, Hungary, Serbia and Thai were determined by DPPH * and ABTS * + scavenging assays. The IC 50 value of the DPPH * scavenging activity of Hungarian SH was 26.62 � 0.49 mg/mL; [38] the IC 50 value of DPPH * scavenging activity of Romanian SH was 65.80 � 2.01 mg/mL; [39] the IC 50 value of ABTS * + scavenging activity of Portuguese SH was found to be 3.17 mg/mL; [40] IC 50 value of DPPH * scavenging activity of SH from Serbia was 324 � 5.51 mg/mL; [41] IC 50 value of DPPH * and ABTS * + scavenging activities of Thai SHs were as 0.06 and 0.59 g/mL, respectively. [42] Antimicrobial and anti-QS activities…”

Section: Phenolic Compoundsmentioning

confidence: 97%

HPLC‐DAD Analysis and Versatile Bioactivities of Turkish Sunflower Honeys Using Chemometric Approaches

Duru

Eroğlu

Tel‐Çayan

et al. 2023

Chemistry & Biodiversity

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Sunflower honey (SH) is bright yellow, fragrant, pollen‐flavoured, slightly herbaceous and has a unique taste. The present research aims to examine the enzyme inhibitory, antioxidant, anti‐inflammatory, antimicrobial and anti‐quorum sensing activities and phenolic compositions of 30 sunflower honeys (SHs) produced from several regions of Turkey with chemometric study. SAH from Samsun exhibited the best antioxidant activity in β‐carotene linoleic acid (IC50: 7.33±0.17 mg/mL) and CUPRAC (A0.50: 4.94±0.13 mg/mL) assays, anti‐urease activity (60.63±0.87 %) and anti‐inflammatory activity against COX‐1 (73.94±1.08 %) and COX‐2 (44.96±0.85 %). SHs exhibited mild antimicrobial activity against the test microorganisms while they showed high quorum sensing inhibition zones measured in the range of 42–52 mm against the CV026 strain. The phenolic composition was determined by high performance liquid chromatography with diode array detection (HPLC‐DAD) system and levulinic, gallic, p‐hydroxybenzoic, vanillic and p‐coumaric acids were identified in all studied SHs. The classification of SHs was performed the using PCA and HCA. This study revealed that phenolic compounds and biological properties are effective in classification of SHs according to their geographical origin. The results suggest that studied SHs could be valued as potential agents with versatile bioactivities in oxidative stress‐related disease, microbial infections, inflammation, melanoma, and peptic ulcer.

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Comparative Palynological, Physicochemical, Antioxidant and Antibacterial Properties of Romanian Honey Varieties for Biomedical Applications

Cited by 6 publications

References 59 publications

The amount of antioxidants in honey has a strong relationship with the plants selected by honey bees

The amount of antioxidants in honey has a strong relationship with the plants selected by honey bees

Medical-grade Spore-free Natural Honey is an Effective Choleretic in Neonatal Cholestasis: A Pilot Single-center Trial

HPLC‐DAD Analysis and Versatile Bioactivities of Turkish Sunflower Honeys Using Chemometric Approaches

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