Comparative Percutaneous Absorption of Lindane and Permethrin

Franz, Thomas; Lehman, Paul A.; Franz, S. F.; Guin, Jere D.

doi:10.1001/archderm.1996.03890320049007

Cited by 85 publications

(20 citation statements)

References 23 publications

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“…Topical exposure to this insecticide is the most common route of exposure in humans. Further, permethrin has been shown to cross the skin in mice (Grissom, Brownie, and Guthrie 1987;Baynes, Halling, and Riviere 1997), rats and monkeys (Sidon, Moody, and Franklin 1988), rabbits (Snodgrass 1992), guinea pigs and humans (Franz et al 1996), suggesting possible systemic effects. The two most noteworthy observations from the present studies were thymic atrophy and inhibited contact hypersensitivity (CH) response in mice following topical exposure to permethrin.…”

Section: Discussionmentioning

confidence: 99%

Topical Permethrin Exposure Causes Thymic Atrophy and Persistent Inhibition of the Contact Hypersensitivity Response in C57BI/6 Mice

et al. 2000

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Permethrin was applied to the shaved dorsal interscapular region of female C57Bl/6 mice at doses of 0.5 or 1.5 µ l/day in corn oil and neat 5.0 µ l/day. These doses corresponded to approximately 22, 66, and 220 mg/kg/day topical permethrin. Mice were exposed in this manner either daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. Body weight was not affected by any of the treatment regimens. However, thymic weight was decreased and splenic weight was increased by 1.5 or 5.0 µ l permethrin/day, 2 days after termination of 10 consecutive days of topical chemical exposure. Cell surface antigen expression did not change in any treatment group on thymocytes (CD4, CD8), splenocytes (CD45R, Thy 1.2), or bone marrow cells (CD45, CD45R). A persistent, dose-related inhibition of the contact hypersensitivity (CH) response occurred in mice at all exposure levels of permethrin tested.

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Section: Discussionmentioning

confidence: 99%

Topical Permethrin Exposure Causes Thymic Atrophy and Persistent Inhibition of the Contact Hypersensitivity Response in C57BI/6 Mice

et al. 2000

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“…This phenomenon was in accordance with the previous study. After guinea pigs were dermally exposed to permethrin, the measured permethrin in brain was 7-fold higher than that in plasma at 24 h [40]. It might be attributed to the high fat content of the brain, resulting in the accumulation in brain.…”

Section: Degradation Studiesmentioning

confidence: 93%

Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards ( Eremias argus ) Following Oral Administration

Chen

Diao

et al. 2016

Journal of Hazardous Materials

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“…Usually, the topical agents did not reach such a high serum level to induce AGEP. However, by general and repeated application of the lipophilic lindane solution, the serum level can be elevated [1]. This is a possible explanation of why AGEP induced by other topical agents had not been reported before.…”

mentioning

confidence: 88%

“…Transcutaneous absorption is of concern, especially in infants and small children [1]. Systemic untoward effects of lindane include eczema, urticaria, aplastic anemia and symptoms related to central nervous system intoxication such as lethargy, nausea and drowsiness [2].…”

mentioning

confidence: 99%