Comparative performance of three ceramic bone graft substitutes

Hing, Karin A.; Wilson, Lester; Buckland, Thomas

doi:10.1016/j.spinee.2006.07.017

Cited by 268 publications

(203 citation statements)

References 84 publications

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“…A study that evaluated β-TCP blocks with different pore sizes found that fast resorption was associated with lower bone content and more soft tissue within the blocks (von Doernberg et al 2006). Another study of porous β-TCP struts implanted into an osteochondral defect in rabbits showed signs of rapid resorption, and β-TCP degradation products were found to provoke an inflammatory response that impaired and reversed bone apposition (Hing et al 2007). Our histological preparation of the implant-tissue interface did not allow an analysis of inflammatory response, but there was no sign of inhibition of bone growth in implants with advanced resorption.…”

Section: Discussionmentioning

confidence: 99%

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

et al. 2008

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Background and purpose We studied whether osseointegration and fixation of plasma-sprayed titanium implants grafted with β-TCP granules (Ossaplast) can be improved by adding an osteogenic signal (Colloss E). The results were compared to implants grafted with fresh frozen morselized allograft with and without the Colloss E device.Methods 4 porous-coated Ti implants were placed in the proximal humeri in each of 10 dogs. All implants were surrounded by a 2.5-mm defect, which was grafted with: (A) β-TCP, (B) β-TCP + 20 mg Colloss E, (C) allograft, or (D) allograft + 20 mg Colloss E. The observation time was 4 weeks.Results Mechanical testing showed that the β-TCP group with Colloss E was twice as well fixed as the control group grafted with β-TCP granules alone, and comparable to both allograft groups. We found that every control implant in the β-TCP grafted group was covered by a dense fibrous membrane. No fibrous tissue was seen in the β-TCP group augmented with Colloss. These implants were well osseointegrated, with new bone covering 10-25% of the implant surface. Both treated groups had increased graft resorption compared to their respective control groups. Colloss E had no effect on new bone formation or fibrous tissue reduction around the allografted implants.Interpretation The Colloss E device improved early osseointegration of implants grafted with β-TCP granules and increased their mechanical implant fixation to the level of allografted implants. The experiment

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Section: Discussionmentioning

confidence: 99%

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

et al. 2008

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“…The residual phosphate was removed by soaking the granules in 10% v/v CH 3 COOH for 1 hr under agitation, which effectively removes the residual phosphate without dissolving synthesised phosphate [34,35]. The resultant granules were washed in dH 2 …”

Section: Methodsmentioning

confidence: 99%

“…Ideally, the bone void filler should be resorbed and replaced through sequential remodelling cycles that are synchronised with the natural remodelling process. This will ensure that mechanical stability and metabolic function are maintained at the defect site and minimise the risk of failure from infection [2,3]. Over recent years, an increasing number of synthetic bone substitutes have become clinically available as alternatives to traditional graft materials [4,5].…”

Section: Introductionmentioning

confidence: 99%

An in vitro Study to Assess the Potential of a Unique Micro porous Algal Derived Cap Bone Void Filler in Comparison with Clinically-Used Bone Void Fillers

Walsh¹

2011

J Tissue Sci Eng

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“…As early as 1920, there were reports that b-TCP, when injected into the gap of a segmental bony defect, increased bone union. 5 In research models, b-TCP has been used as an empty scaffold to promote bone healing in rats 40 and has also been shown to promote bone regeneration in cranial defects of canines when the scaffold is seeded with bone marrow-derived stromal cells. 114 Additionally, investigators have used a composite scaffold composed of b-TCP, collagen, and autologous bone fragments fixated with fibrin glue to correct cranial defects in canines.…”

Section: Calcium Phosphate Scaffoldsmentioning

confidence: 99%

Cranial bone defects: current and future strategies

Szpalski¹,

Barr²,

Wetterau³

et al. 2010

FOC

182

118

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Bony defects in the craniomaxillofacial skeleton remain a major and challenging health concern. Surgeons have been trying for centuries to restore functionality and aesthetic appearance using autografts, allografts, and even xenografts without entirely satisfactory results. As a result, physicians, scientists, and engineers have been trying for the past few decades to develop new techniques to improve bone growth and bone healing. In this review, the authors summarize the advantages and limitations of current animal models; describe current materials used as scaffolds, cell-based, and protein-based therapies; and lastly highlight areas for future investigation. The purpose of this review is to highlight the major scaffold-, cell-, and protein-based preclinical tools that are currently being developed to repair cranial defects.

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Comparative performance of three ceramic bone graft substitutes

Cited by 268 publications

References 84 publications

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

An in vitro Study to Assess the Potential of a Unique Micro porous Algal Derived Cap Bone Void Filler in Comparison with Clinically-Used Bone Void Fillers

Cranial bone defects: current and future strategies

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