Comparative pharmacokinetics of cefquinome following intravenous and intramuscular administration in goats

Dumka, V. K.; Dinakaran, V.; Ranjan, Bibhuti; Rampal, Satyavan

doi:10.1016/j.smallrumres.2013.02.010

Cited by 31 publications

(34 citation statements)

References 21 publications

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“…CFQ in red‐eared slider turtles displayed a small V dss with the mean value of 0.37 L/kg, which was similar to the ranged of 0.36–0.49 L/kg reported in some mammalian and avian species (Dumka et al., ; Li et al., ; Uney et al., ; Xie et al., ; Yuan et al., ) and to a V dss of 0.42 L/kg following ceftazidime administration in loggerhead sea turtles (Stamper et al., ). This limited distribution of CFQ might be due to its hydrophilic nature and low pKa values of 2.51 or 2.91 (CVMP, ).…”

Section: Pharmacokinetic Parameters Of Cfq In Red‐eared Sliders (N = supporting

confidence: 79%

“…The dose of CFQ used in the present study (2 mg/kg) was chosen based on pharmacokinetic data in several mammalian (Dumka, Dinakaran, Ranjan, & Rampal, ; Hwang et al., ; Li et al., ; Uney et al., ) and avian species (Xie et al., ). Our results suggested that single IV or IM administration of 2 mg/kg CFQ was well tolerated and did not cause clinically adverse effects.…”

Section: Pharmacokinetic Parameters Of Cfq In Red‐eared Sliders (N = mentioning

confidence: 99%

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Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Üney

Altan

Gül

et al. 2017

Vet Pharm & Therapeutics

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The purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2 mg/kg body weight in red-eared slider turtles. Plasma concentrations of CFQ were determined by high-performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: , and total body clearance (Cl T ) 12.66 ± 2.51 ml hr −1 kg −1. The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (C max ) 3.94 ± 0.84 μg/ml, time to peak concentration (T max ) 3 hr, t 1/2λz26.90 ± 4.33 hr, and AUC 0-∞ 145 ± 48 μg hr −1 ml −1. The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half-life and a high bioavailability in red-eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.

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Section: Pharmacokinetic Parameters Of Cfq In Red‐eared Sliders (N = supporting

confidence: 79%

Section: Pharmacokinetic Parameters Of Cfq In Red‐eared Sliders (N = mentioning

confidence: 99%

Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Üney

Altan

Gül

et al. 2017

Vet Pharm & Therapeutics

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“…The plasma concentration–time profile following single IM dose of cefquinome in buffalo calves was best described by a mono‐compartment open model which is similar to that `described in goats (Dumka et al., ) and camels (Al‐Taher, ). However, a two‐compartment model was shown to provide the best fit for IM cefquinome plasma concentration–time data in sheep (Uney et al., ).…”

Section: Pharmacokinetic Parameters (Mean ± Sd) Of Cefquinome In Buffmentioning

confidence: 86%

“…Cefquinome is one of the fourth‐generation cephalosporins developed exclusively for use in animals and has been used in the treatment of respiratory tract diseases, acute mastitis, and foot rot in cattle, calf septicemia, respiratory diseases in pigs, metritis,mastitis, and agalactia syndrome in sows, foal septicemia, and respiratory tract diseases in horses (CVMP, , , ). Pharmacokinetics of cefquinome following intramuscular (IM) administration have been reported in lactating cows (Ehinger, Schmidt, & Kietzmann, ), goats (Dumka, Dinakaran, Bibhuti, & Satyavan, ), sheep (Tohamy, ; Uney, Altan, & Elmas, ), and camels (Al‐Taher, ), and the pharmacokinetics following intravenous (IV) administration have been reported in buffalo calves (Dinakaran, Dumka, Ranjan, Balaje, & Sidhu, ), horses (Dumka et al., ) and goats (Dumka et al., ). However, there are no published report on the disposition and bioavailability of cefquinome following IM administration in buffalo calves.…”

Section: Pharmacokinetic Parameters (Mean ± Sd) Of Cefquinome In Buffmentioning

confidence: 99%

Pharmacokinetics of a single intramuscular injection of cefquinome in buffalo calves

Venkatachalam

Dumka

Ranjan

2017

Vet Pharm & Therapeutics

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The objective of this study was to investigate the pharmacokinetics of cefquinome following single intramuscular (IM) administration in six healthy male buffalo calves.Cefquinome was administered intramuscularly (2 mg/kg bodyweight) and blood samples were collected prior to drug administration and up to 24 hr after injection. No adverse effects or changes were observed after the IM injection of cefquinome.Plasma concentrations of cefquinome were determined by high-performance liquid chromatography. The disposition of plasma cefquinome is characterized by a monocompartmental open model. The pharmacokinetic parameters after IM administration (mean ± SE) were C max 6.93 ± 0.58 μg/ml, T max 0.5 hr, t ½kα 0.16 ± 0.05 hr, t ½β 3.73 ± 0.10 hr, and AUC 28.40 ± 1.30 μg hr/ml after IM administration. A dosage regimen of 2 mg/kg bodyweight at 24-hr interval following IM injection of cefquinome would maintain the plasma levels required to be effective against the bacterial pathogens with MIC values ≤0.39 μg/ml. The suggested dosage regimen of cefquinome has to be validated in the disease models before recommending for clinical use in buffalo calves.

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“…The beta-lactam antiobiotic is safer in the target animals as compared to other antibiotics (Dumka et al, 2013). The beta lactam antibiotic is time dependent and its bactericidal activity is lower as compared to other bactericidal antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle

et al. 2015

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Cefquinome is a fourth generation cephalosporin with antimicrobial activity against gram negative and gram positive bacterial species, including Staphylococcus aureus. The aim of our study was to observe the ex-vivo activity of cefquinome against Staphylococcus aureus strains by using bovine serum from intravenously treated cattle. Cefquinome kinetics were measured by liquid chromatography and UV detection. In vitro post antibiotic effects (PAEs) and mutant prevention concentrations were determined with S. aureus strain ATCC 12598. Cefquinome exhibited time-dependent killing and produced in vitro PAEs increasing with concentration and time of exposure. A pharmacokinetic-pharmacodynamic model was established to simulate the efficacy of cefquinome for different dosage regimens. A dosage of 2 mg/kg every 12 h for 3 days was expected to reach a bactericidal activity against S. aureus in case of septicemia.

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Comparative pharmacokinetics of cefquinome following intravenous and intramuscular administration in goats

Cited by 31 publications

References 21 publications

Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Pharmacokinetics of cefquinome in red‐eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

Pharmacokinetics of a single intramuscular injection of cefquinome in buffalo calves

Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle

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