Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species

Baert, Kris; Backer, R De

doi:10.1016/s1532-0456(02)00184-9

Cited by 135 publications

(137 citation statements)

References 22 publications

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“…The plasma half-life of acetaminophen ranges between 1-4 h across various species which could increase in cases of overdose (St. Omer and Mohammad 1984;Bannwarth and Pehourcq 2003;Neirinckx et al 2010). Sodium salicylate administration in birds resulted in a plasma half-life of salicylic acid in the chicken (3.13 h) which was shorter than those in the pigeon and duck (Baert and De Backer, 2003). Neirinckx et al (2010) reported the pharmacokinetics parameters of acetaminophen in five-week old chickens after intravenous and oral administration (10 mg/kg).…”

Section: Resultsmentioning

confidence: 99%

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Comparative single intraperitoneal dose pharmacokinetics of aspirin and acetaminophen in chicks

Mohammad¹,

Mansoor²,

Al-Zubaidy³

2012

Vet. Med. - Czech

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Limited information is available on the pharmacokinetics and bioavailability of aspirin and acetaminophen in young chicks. The purpose of the present study was to examine the pharmacokinetics of acetyl salicylic acid (aspirin) and acetaminophen in 12-day old chicks after a single intraperitoneal administration of each drug alone at the dose of 100 mg/kg body weight. Blood samples were collected from chicks (six/each time period) at 10, 20, 30, 60 and 120 min after each drug administration. The concentrations of aspirin and acetaminophen in the plasma were determined by spectrophotometric methods. The pharmacokinetic parameters of the drugs were calculated by a non-compartmental analysis. The elimination half-lives of aspirin and acetaminophen were 1.68 and 1.36 h with steady state volume of distributions 0.079 and 1.11 l/kg and total body clearances of 0.029 and 0.53 l/h/kg, respectively. The mean residence times of the drugs were 2.74 and 2.09 h and their area under the plasma concentration-time curves (0-∞) were 3486 and 188 μg·h/ml, respectively. In conclusion, the data show the pharmacokinetic profiles of single intraperitoneal doses of aspirin and acetaminophen in chicks and suggest that acetaminophen is well distributed in the body of the chicks and eliminated faster from the body compared to aspirin. These parameters should be taken into consideration in further therapeutic and toxicological studies of drugs in chickens.

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Section: Resultsmentioning

confidence: 99%

“…Limited information is available on the pharmacokinetics and bioavailability of aspirin and acetaminophen in young chicks (Lambert et al 1986;Baert and De Backer 2003). De Backer (2002, 2003) have reported the pharmacokinetic parameters of sodium salicylate after intravenous administration in adult chickens.…”

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confidence: 99%

Comparative single intraperitoneal dose pharmacokinetics of aspirin and acetaminophen in chicks

Mohammad¹,

Mansoor²,

Al-Zubaidy³

2012

Vet. Med. - Czech

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“…The lack of effect on latency was not surprising because bioavailability was anticipated to be highest several hours after dosing (Baert & DeBacker, 2002, 2003Hothersall et al, 2012). The LTL results were more promising, with standing times being longer in lame birds administered either NSAID 5h previously.…”

Section: Discussionmentioning

confidence: 99%

“…Graphical data presented as part of this study indicated that the most substantial improvement occurred 2-6 h post-treatment. Baert & DeBacker (2002, 2003 described pharmacokinetic parameters of an intravenous dose of meloxicam at 0.5mg/kg in broiler chickens based on doses previously used in other species. They reported an elimination half-life of 3.21 hours, but did not include a behavioural assay.…”

Section: Introductionmentioning

confidence: 99%

Effects of carprofen, meloxicam and butorphanol on broiler chickens’ performance in mobility tests

Hothersall

Caplen

Parker³

et al. 2016

Anim. welf.

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(Gait Score (GS) 2.5-4) and non-lame (GS 0-1) broilers administered analgesia or a saline control.We used exploratory subcutaneous doses of the Non-Steroidal Anti-Inflammatory Drugs meloxicam (5mg/ kg) or carprofen (35mg/kg) or the opioid butorphanol tartrate (4mg/kg). We included butorphanol to explore the possibility that NSAID drugs could improve mobility by reducing inflammation without necessarily invoking an analgesic effect. Lameness was a significant predictor in all analyses. Neither the number of obstacle crossings nor latency to cross an obstacle was significantly changed by either NSAID, but LTL was longer in lame birds given carprofen and meloxicam than in lame birds given saline. LTL was associated with foot pad dermatitis and ameliorated by both NSAIDS. Butorphanol did not affect LTL but appeared soporific in the obstacle test, increasing latency to cross and, in non-lame birds, reducing the number of crossings. Combined with data from other studies, the results suggest carprofen and meloxicam had some analgesic effect on lame birds, lending further support to concerns that lameness compromises broiler welfare. Further investigation of opioid treatments and lameness types is needed to disentangle effects on mobility and on pain.

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“…Medication doses and frequency were based on literature (Likoff et al 1981;Huff et al 1998Huff et al , 2004Baert and De Backer 2003;Jayakumar et al 2010). In order to maximize the chance of efficacy, drugs were administered long term, i.e.…”

Section: Introductionmentioning

confidence: 99%

Effect of anti-inflammatory drugs on colibacillosis lesions in broilers afterInfectious Bronchitis Virusand subsequentEscherichia coliinfection

Landman

Matthijs

Eck

2012

Veterinary Quarterly

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Background: In case of persistent and sterile inflammation, anti-inflammatory drugs should be considered as first choice treatment instead of antibiotics. Objective: To assess the effect of anti-inflammatory drugs on lesions due to colibacillosis. Animals & methods: Five groups of day-old broilers of 15 birds each were housed in isolators and were inoculated at 29 days of age with Infectious Bronchitis Virus strain M41 by the oculo-nasal and IT (intratracheal) route (10 5.4 EID 50 (egg infectious dosis 50)/broiler) and at 33 days of age with Escherichia coli strain 506 by the IT route (10 7.6 colony forming units/broiler). Broilers of four groups were treated from day 28 up to and including day 39 orally on a daily basis with either carbasalate calcium (4 Â 12.5 mg), meloxicam (2 Â 0.5 mg), acetaminophen (4 Â 2.5 mg), or dexamethasone (1 Â 1.0 mg). The fifth group was placebo-medicated. At 40 days of age, the experiment was ended and at post-mortem examination, colibacillosis lesions were assessed. Results: All broilers in the dexamethasone group died. This mortality exceeded significantly (p 5 0.05) that of the other groups in which mortality ranged from 2 to 5. Mean lesion score of surviving broilers of medicated groups ranged from 5.3 to 5.8 compared to 3.9 in the placebo group and did not differ significantly between groups. Conclusion: None of the anti-inflammatory drugs had a positive effect on colibacillosis lesions. Clinical importance: Anti-inflammatory drugs cannot be considered as an alternative for antibiotic treatment.

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Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species

Cited by 135 publications

References 22 publications

Comparative single intraperitoneal dose pharmacokinetics of aspirin and acetaminophen in chicks

Comparative single intraperitoneal dose pharmacokinetics of aspirin and acetaminophen in chicks

Effects of carprofen, meloxicam and butorphanol on broiler chickens’ performance in mobility tests

Effect of anti-inflammatory drugs on colibacillosis lesions in broilers afterInfectious Bronchitis Virusand subsequentEscherichia coliinfection

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