Introduction: Surgical site infections are the most common nosocomial infections worldwide and are also the common problem in developing countries. The impact of its prevalence contributes to morbidity and mortality and therefore the need to determine its prevalence is necessary. Finding out the prevalence of surgical site infections and the frequency of risk variables for surgical site infections in patients undergoing abdominal surgeries at Abbasi Shaheed Hospital in Karachi is the aim of this study. Methodology: This descriptive study was carried out from February 22, 2022- August 22, 2022 at the Abbasi Shaheed Hospital in Karachi with a sample size of 157 subjects with abdominal surgery fulfilling the inclusion criteria. Results: In our study, the mean age, length of operation and BMI were 49.87±8.74 years, 2.14±1.87 hours, 29.72±3 respectively with 61.1% of female and 38.9% male subjects. Out of 157 patients, 22 (14%) and 135 (86%) had and did not have surgical site infection. Conclusion: Patients and the healthcare systems are both heavily impacted by the effects of SSIs. A comprehensive strategy addressing pre-, intra-, and postoperative variables is necessary for the prevention of SSI. In order to lower SSI, hospital infection control procedures should be developed in conjunction with the establishment of an ongoing, long-term surveillance system to detect risk factors.