Comparative sequence analysis of B5R gene of zoonotic buffalo pox virus isolates with other orthopoxviruses

Chandranaik, B. M.; Singh, Raj Kumar; Hosamani, M.; Krishnappa, G.; Harish, Balur R.; Chethana, C. S.; Renukaprasad, C.

doi:10.1007/s11250-010-9700-5

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…Buffalopox is endemic with increasing trend in India (Prabhu et al, 2012) and outbreaks are reported from Maharashtra, Gujarat, Rajasthan, Andhra Pradesh, Tamilnadu and Karnataka states in India (Figure 3) Bhanuprakash et al, 2010c;Chandranaik et al, 2011;Gurav et al, 2011). Apart from Egypt, India, it is also been reported from several other countries namely Italy, Russia, Pakistan, Indonesia, Bangladesh and Nepal .…”

Section: Geographical Distributionmentioning

confidence: 99%

Camelpox and Buffalopox: Two Emerging and Re-emerging Orthopox Viral Diseases of India

Prabhu¹

2015

Adv. Anim. Vet. Sci.

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| World Health Assembly declared that the world is free from smallpox virus infection and vaccination against smallpox is not recommended since May 8, 1980. Since then several incidences of infections due to poxvirus reported in different parts of the world in humans and animals and the trend has now been increasing. In India, camelpox and buffalopox are the two important Orthopoxvirus (OPV) infections considered as emerging public health concern since last decade due to augmented reports of outbreaks and isolated cases. Both are highly contagious zoonotic viral diseases. Camelpox is an economically important, notifiable skin disease of camelids and could be used as a potential bio-warfare agent. Though, vaccines are available in few countries, this disease has received much attention in present days due to emergence of infections in human beings. Buffalopox is also causing tangible and intangible losses in affected herds which has no commercial vaccines at field to protect. Hence, novel, specific, sensitive, rapid and cost-effective diagnostic techniques would be useful in identification, thereby early implementations of therapeutic and preventives measures to curtail these diseases. This review provides an overview on the epidemiology, clinical picture, biology, diagnostic approaches and the preventive measures on the two emerging and re-emerging disease of India viz. camelpox and buffalopox.

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Section: Geographical Distributionmentioning

confidence: 99%

Camelpox and Buffalopox: Two Emerging and Re-emerging Orthopox Viral Diseases of India

Prabhu¹

2015

Adv. Anim. Vet. Sci.

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“…Buffalopox virus (BPXV), a variant of vaccinia virus, is associated with severe disease outbreaks among buffaloes and cattle . The disease also occurs in humans in close contact with BPXV affected animals . In recent years, infection because of vaccinia and vaccinia‐like Contagalo and Aracatuba viruses has been reported from South American counties .…”

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“…Scab lesions collected from ailing farmers and buffaloes for laboratory investigations were processed and inoculated separately in 9‐day‐old chick embryos by chorio‐allontoic membrane (CAM) route and on to confluent monolayer of Vero cells as per previously described procedures . Characteristic pock lesions on CAM of chicken embryos (Fig.…”

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Isolation and molecular characterization of zoonotic Buffalopox virus from skin lesions of humans in India

et al. 2018

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“…Молекулярно-биологическая оценка выделенных за последние 20 лет от человека и буйволов изолятов показала, что все они относятся к вирусу оспы буйволов. Важно отметить, что все штаммы вируса оспы буйволов, выделенные на территории Индии, практически не различаются, но отличаются от изолированных в других странах, кроме штамма Hyderabad: различия для ATIгена составляют 0,3% [30,31].…”

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Buffalopox

Borisevich

Маренникова

Stovba

et al. 2016

Problems of Virology

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Buffalopox is a contagious viral disease affecting milch buffaloes (Bubalus Bubalis) and, rarely, cows. The disease has zoonotic implications, as outbreaks are frequently associated with human infections, particularly in the milkers. Buffalopox is associated with high morbidity (80%). The clinical symptoms of the disease are characterized by wartline lesions on the udder, teats, inguinal region, base of the ears, and over the parotid. In the severe form, generalized rash is observed. Although the disease does not lead to high mortality, it has an adverse effect on the productivity and working capacity of the animals resulting in large economic losses. The outbreaks of buffalopox occurred frequently in India, Pakistan, Bangladesh, Nepal, Iran, Egypt, and Indonesia, where buffaloes are reared as milch animals. The buffalopox is closely related with other Orthopoxviruses. In particular, it is close to the vaccinia virus. There is a view that the buffalopox virus might be derived from the vaccinia virus. It is possible that it became pathogenic to humans and animals through adaptive evolution of the genome by obtaining the virulence genes. PCR is performed for the C18L gene for the purpose of specific detection and differentiation of the buffalopox virus from other orthopoxviruses. The C18L gene encodes the ankyrin repeat protein, which determines the virus host range. The open reading frame of this gene is only 150-nucleotide long as against 453 nucleotide in the vaccinia virus, 756 - in the camelpox virus, and 759 - in the cowpox virus. It can be concluded that a systematic study based on the epidemiology of the virus, existence of reservoirs, biological transmission, and the molecular organization of the buffalopox virus from buffalo, cow, and humans may pave the way to a better understanding of the circulating virus and contribute to the control of the disease using the suitable diagnostic and prophylactic measures.

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Comparative sequence analysis of B5R gene of zoonotic buffalo pox virus isolates with other orthopoxviruses

Cited by 5 publications

References 14 publications

Camelpox and Buffalopox: Two Emerging and Re-emerging Orthopox Viral Diseases of India

Camelpox and Buffalopox: Two Emerging and Re-emerging Orthopox Viral Diseases of India

Isolation and molecular characterization of zoonotic Buffalopox virus from skin lesions of humans in India

Buffalopox

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