The purpose of this paper is to identify and analyze the determinants influencing technology-driven initiatives in project-based organizations in Pakistan. Technology-driven initiatives help organizations to improve the efficiency and effectiveness of business processes, products, and services and are a major source of completive advantage. These initiatives have become more important for project-based organizations to improve project efficiency, reduce cost, and enhance effectiveness. Many organizations in Pakistan have structured their hierarchy as project-based organizations and strived to implement technology-driven initiatives to enhance innovation and improve project performance. However, for envisaged improvement, the well-recognized determinants influencing technology-driven initiatives have not been previously analyzed in this context. This study has filled this gap and identified and analyzed four determinants influencing technology-driven initiatives in project-based organizations in Pakistan. This has achieved by developing an explanatory model and testing the model using sample data from 98 respondents. The PLS-SEM-based hierarchical component modeling approach has been applied for data analysis. The results indicate that human resource management practices and organizational culture positively influence technology-driven initiatives in this context. Political deadlocks negatively influence technology-driven initiatives. However, leadership inaction shows no significant influence on technology-driven initiatives. The results are useful for theory and practice.