Comparative Studies in Relation to the Structure and Biochemical Properties of the Active Compounds in the Volatile and Nonvolatile Fractions of Turmeric (C. longa) and Ginger (Z. officinale)

Jacob, James N.

doi:10.1016/b978-0-444-63602-7.00004-7

Cited by 20 publications

(14 citation statements)

References 111 publications

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“…It was active against human mouth epidermal carcinoma (KB) cells and mouse leukemia (P388) cells, with respective IC 50 values of 1.088 and 0.084 mg/mL [ 177 ]. It was also cytotoxic to the pancreatic cancer (PANC-1), melanoma (B16), prostate cancer (LNCaP), and human cervical adenocarcinoma (HeLa) cell lines due to the presence of ar -turmerone, α-turmerone, β-turmerone, curlone, ar -curcumene, zingiberene, and β-sesquiphellandrene [ 23 , 74 , 175 , 176 ]. Crude organic extracts of turmeric-inhibited lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)-α (IC 50 = 15.2 μg/mL) and prostaglandin E2 (PGE2; IC 50 = 0.92μg/mL) in human leukemia (HL-60) cells [ 181 ].…”

Section: Biological Activities Of Curcuma Oilsmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

2018

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Members of the genus Curcuma L. have been used in traditional medicine for centuries for treating gastrointestinal disorders, pain, inflammatory conditions, wounds, and for cancer prevention and antiaging, among others. Many of the biological activities of Curcuma species can be attributed to nonvolatile curcuminoids, but these plants also produce volatile chemicals. Essential oils, in general, have shown numerous beneficial effects for health maintenance and treatment of diseases. Essential oils from Curcuma spp., particularly C. longa, have demonstrated various health-related biological activities and several essential oil companies have recently marketed Curcuma oils. This review summarizes the volatile components of various Curcuma species, the biological activities of Curcuma essential oils, and potential safety concerns of Curcuma essential oils and their components.

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Section: Biological Activities Of Curcuma Oilsmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

2018

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“…Cyclocurcumin,(E)-2-4-hydroxy-3-methoxyphenyl-6-(4-hydrox-3-methoxystyryl)2H-pyra-4(3H)-one, isolated and identified from turmeric have some structural similarities to curcumin. They are formed by the addition of enol oxygen group through intramolecular Michael addition to enone group [9]. They have shown inhibitory action on breast cancer (MCF-7) cells [12].…”

Section: Non-curcuminoids As Anticancer Agentsmentioning

confidence: 99%

“…This rhizomatous herbaceous perennial plant found abundantly in Asia is renowned for its cosmetic, culinary, color, and medicinal applications for centuries [7,8]. Basically, its volatile oil and nonvolatile oleoresin constitutes of bioactive components, which are classified as diphenylheptanoids (nonvolatile) diphenylpentanoids (nonvolatile), phenyl propene (cinnamic acid type) derivatives (nonvolatile), turmeric oil containing terpenoids (volatile) [9]. Major diphenylheptanoids are curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which are collectively called curcuminoids [10,11].…”

Section: Introductionmentioning

confidence: 99%

Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations

Nair¹,

Amalraj²,

Jacob³

et al. 2019

Biomolecules

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Over the past decades curcuminoids have been extensively studied for their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypotensive, antihypocholesteremic, and anticancer activities. With the perception of limited toxicity and cost, these compounds forms an integral part of cancer research and is well established as a potential anticancer agent. However, only few studies have focused on the other bioactive molecules of turmeric, known as non-curcuminoids, which are also equally potent as curcuminoids. This review aims to explore the comprehensive potency including the identification, physicochemical properties, and anticancer mechanism inclusive of molecular docking studies of non-curcuminoids such as turmerones, elemene, furanodiene (FN), bisacurone, germacrone, calebin A (CA), curdione, and cyclocurcumin. An insight into the clinical studies of these curcumin-free compounds are also discussed which provides ample evidence that favors the therapeutic potential of these compounds. Like curcuminoids, limited solubility and bioavailability are the most fragile domain, which circumscribe further applications of these compounds. Thus, this review credits the encapsulation of non-curcuminoid components in diverse drug delivery systems such as co-crystals, solid lipid nanoparticles, liposomes, microspheres, polar-non-polar sandwich (PNS) technology, which help abolish their shortcomings and flaunt their ostentatious benefits as anticancer activities.

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“…Several studies indicated that the bioactive ingredients of Curcuma rhizome are the non-volatile curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) and the volatile oil (sesquiterpenoids and monoterpenoids) [14,18]. Curcumin, the most active curcuminoid in turmeric rhizome, has anticancer [19], anti-inflammatory [20], antioxidant [21], antibacterial, anti-fungal [22], analgesic, digestive, antidepressant [23], and hypoglycemic [23] properties and has shown potential against cardiovascular diseases [24] and Alzheimer’s disease [25]. Curcuma essential oil (EO) is often extracted by distillation of the fresh or dry rhizome [26], or by supercritical fluid extraction [27].…”

Section: Introductionmentioning

confidence: 99%

Variations in the Volatile Compositions of Curcuma Species

Dosoky

Satyal

Setzer

2019

Foods

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Curcuma species have been cultivated in tropical and subtropical regions in Asia, Australia, and South America for culinary as well as medicinal applications. The biological activities of Curcuma have been attributed to the non-volatile curcuminoids as well as to volatile terpenoids. Curcuma essential oils have demonstrated a wide variety of pharmacological properties. The objective of this work was to examine the variation in the compositions of Curcuma rhizome essential oils. In this work, the volatile oils from C. longa and C. zedoaria were obtained and analyzed by gas chromatography-mass spectrometry. The chemical compositions of C. longa and C. zedoaria essential oils, including those reported in the literature, were analyzed by hierarchical cluster analysis. In addition, cluster analyses of the chemical compositions of C. aromatica and C. aeruginosa from the literature were also carried out. Curcuma longa volatiles were dominated by α-turmerone, curlone, ar-turmerone, β-sesquiphellandrene, α-zingiberene, germacrone, terpinolene, ar-curcumene, and α-phellandrene and showed four distinct chemical clusters. C. zedoaria rhizome oil contained 1,8-cineole, curzerenone/epi-curzerenone, α-copaene, camphor, β-caryophyllene, elemol, germacrone, curzerene, and β-elemene and showed two different chemical types. C. aromatica had three clearly defined clusters, and C. aeruginosa had three types.

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Comparative Studies in Relation to the Structure and Biochemical Properties of the Active Compounds in the Volatile and Nonvolatile Fractions of Turmeric (C. longa) and Ginger (Z. officinale)

Cited by 20 publications

References 111 publications

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations

Variations in the Volatile Compositions of Curcuma Species

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