Comparative studies in vivo of free and liposomal forms of photosensitizer on a base of hydrophilic derivative of chlorin e6

Comparison of a new nanoform of the photosensitizer chlorin e6, based on plant phospholipids, with its free form

“…In Ref. the results were presented of studying Ce6 accumulation in tumors, and the enhancement of PDT efficacy of Ce6 incorporated in the liposomal particles based on egg phosphatidylcholine and poly(ethylene glycol) of about 200 nm in size was noted. In general, a consensus in literature exists that decreasing carrier size will improve tumor deposition .…”

“…For example, Yen et al . report growth of PDT efficacy and increased accumulation of di‐ N ‐methylglucamine salt of Ce6 in tumors when included in liposomes based on egg phosphatidylcholine, cholesterol and poly(ethylene glycol) with size of 178 ± 10 nm. Similarly, Namiki et al .…”

“…Analysis of the literature shows that using liposomes as delivery systems for PSs protect them from inactivation in the plasma during blood circulation, facilitates their accumulation in the tumor tissue and increases photocytotoxicity, all of which improves PDT efficacy. For example, Yen et al [20] report growth of PDT efficacy and increased accumulation of di-N-methylglucamine salt of Ce6 in tumors when included in liposomes based on egg phosphatidylcholine, cholesterol and poly(ethylene glycol) with size of 178 AE 10 nm. Similarly, Namiki et al [21] used Ce6 sodium salt (Ce6-Na) as an example to show that Ce6, when included in stealth liposomes of 100 nm in diameter, had substantially better penetration into cells in vitro and efficiently inhibited tumor growth in vivo.…”

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†

“…These allow the release of the PS or drugs in specific sites of the cell increasing the selectivity and bioaccumulation in the tumor cell and have shown an elevated photodynamic efficiency. In particular, Yen et al (78) described the use of liposomes to include hydrophilic active substance (chlorin e6 di-N-methylglucaminate) in comparison with the commercially available aqueous solution, this result showed a significant enhancement of the level and selectivity of biodistribution of the photosensitizer in tumor tissue compared with normal tissue through the use of liposomes, consequently resulting in a significant enhancement of photodynamic efficiency in comparison to the original commercially produced drug form (aqueous solution) of Fotoditazin.…”