Comparative Studies of Asymptomatic Proteinuria and Hematuria

Chen, Beatrice T. M.

doi:10.1001/archinte.1974.00320230111022

Cited by 22 publications

(9 citation statements)

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“…Chen et at. [4] found all but 4 patients had normal renal histological findings of 25 young men with persistent asymptomatic proteinuria. These findinge are at variance with the results presented here.…”

Section: Discussionmentioning

confidence: 81%

Clinicopathological Correlations of Persistent Asymptomatic Proteinuria in Children

Yoshikawa¹,

Uehara²,

Yamana³

et al. 1980

Nephron

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36 patients with persistent asymptomatic proteinuria were studied over an average period of 2.9 years. All fulfilled the following criteria: persistent proteinuria, normal blood pressure, renal function and pyelogram, no previous nor family history of renal disease. Renal biopsy showed minimal change or diffuse proliferation of glomeruli. The disappearance of proteinuria correlated inversely with the degree of glomerular sclerosis. 12 of 14 children with minimal or no sclerosis lost their proteinuria. In contrast, in 8 of 11 patients with moderate sclerosis and in all 7 patients with marked sclerosis proteinuria persisted. Age over 16 years or heavy proteinuria with or without haematuria were indicative of marked glomerular sclerosis. The thickness of the glomerular basement increased with age. Impairment of renal function occurred in only 1 patient.

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Section: Discussionmentioning

confidence: 81%

Clinicopathological Correlations of Persistent Asymptomatic Proteinuria in Children

Yoshikawa¹,

Uehara²,

Yamana³

et al. 1980

Nephron

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“…There is a considerable percentage of cases of unexplained haematuria following urological investigations.16"'8 In studies which actively included renal biopsy in cases of unexplained haematuria, a high percentage have been found to have glomerular disease. In one study, Chen et aP9 found that, in a group of Asian military recruits with asymptomatic haematuria aged [17][18][19][20][21][22][23][24][25] years, 54% had glomerular disease. Topham et aP0 found glomerular disease in 47% of 165 patients with asymptomatic haematuria, with the highest frequency in the younger age groups.…”

Section: Glomerular Diseasementioning

confidence: 99%

Haematuria

Rockall

Newman-Sanders

Al-Kutoubi

et al. 1997

Postgraduate Medical Journal

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“…However glomerular disease is increasingly appreciated to be a common ® nding in patients with isolated haematuriaÐ it was present in 46% and 54% of patients in 2 large studies 9,10 . The commonest patterns of glomerular disease in isolated haematuria are IgA nephropathy and thin membrane nephropathy, both of which may result in progressive renal failure in a signi® cant minority of patients.…”

Section: Introductionmentioning

confidence: 99%

Isolated microscopic haematuria in the genitourinary clinic: the value of renal biopsy

Topham¹,

Young²,

Harper³

et al. 1997

Int J STD AIDS

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Isolated microscopic haematuria is a common finding in the genitourinary clinic. The conventional approach to investigation includes urological referral for cystourethroscopy if renal imaging is normal. However the diagnostic yield is very low; in particular urothelial malignancy at age < 40 years is rare. Glomerular disease is increasingly recognized as a common cause of microscopic haematuria. In this study 50 patients with persistent microscopic haematuria detected at a genitourinary clinic underwent renal biopsy. Twelve (24%) had an abnormal biopsy--IgA nephropathy 6 (12%), thin membrane nephropathy 3 (6%), other glomerulonephritis 3 (6%). In 7 others no abnormality was found but information was incomplete as electron microscopy was unavailable. It is important to establish these diagnoses since some patients will develop progressive renal disease. In this clinical setting renal biopsy will give diagnostic and prognostic information, protects from repeated urological investigation, and allows reassurance if renal histology is normal. Renal biopsy is recommended for patients age < 40 years with persistent microscopic haematuria. An algorithm for the investigation of microscopic haematuria is presented.

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Comparative Studies of Asymptomatic Proteinuria and Hematuria

Cited by 22 publications

References 0 publications

Clinicopathological Correlations of Persistent Asymptomatic Proteinuria in Children

Clinicopathological Correlations of Persistent Asymptomatic Proteinuria in Children

Haematuria

Isolated microscopic haematuria in the genitourinary clinic: the value of renal biopsy

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