Comparative Studies of Hyaluronan in Marketed Ophthalmic Products

Liu, X. Michael; Harmon, Patricia S.; Maziarz, E. Peter; Rah, Marjorie J.; Merchea, Mohinder

doi:10.1097/opx.0000000000000100

Cited by 13 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2, 8 The molecular weight variants have been used in a variety of biomedical applications eliciting varying biologic responses. 9-10 Clinically, HA has been used in several applications, including ophthalmology as a drug delivery system, 11-12 in osteoarthritis for viscosupplementation, 13-15 and as a dermal filler. 16-17 …”

Section: Introductionmentioning

confidence: 99%

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Rayahin

Buhrman

Zhang

et al. 2015

ACS Biomater. Sci. Eng.

491

400

View full text Add to dashboard Cite

Macrophages exhibit phenotypic diversity permitting wide-ranging roles in maintaining physiologic homeostasis. Hyaluronic acid, a major glycosaminoglycan of the extracellular matrix, has been shown to have differential signaling based on its molecular weight. With this in mind, the main objective of this study was to elucidate the role of hyaluronic acid molecular weight on macrophage activation and reprogramming. Changes in macrophage activation were assessed by activation state selective marker measurement, specifically quantitative real time polymerase chain reaction, and cytokine enzyme-linked immunoassays, after macrophage treatment with differing molecular weights of hyaluronic acid under four conditions: the resting state, concurrent with classical activation, and following inflammation involving either classically or alternatively activated macrophages. Regardless of initial polarization state, low molecular weight hyaluronic acid induced a classically activated-like state, confirmed by up-regulation of pro-inflammatory genes, including nos2, tnf, il12b, and cd80, and enhanced secretion of nitric oxide and TNF-α. High molecular weight hyaluronic acid promoted an alternatively activated-like state, confirmed by up regulation of pro-resolving gene transcription, including arg1, il10, and mrc1, and enhanced arginase activity. Overall, our observations suggest that macrophages undergo phenotypic changes dependent on molecular weight of hyaluronan that correspond to either (1) pro-inflammatory response for low molecular weight HA or (2) pro-resolving response for high molecular weight HA. These observations bring significant further understanding of the influence of extracellular matrix polymers, hyaluronic acid in particular, on regulating the inflammatory response of macrophages. This knowledge can be used to guide the design of HA-containing biomaterials to better utilize the natural response to HAs.

show abstract

Section: Introductionmentioning

confidence: 99%

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Rayahin

Buhrman

Zhang

et al. 2015

ACS Biomater. Sci. Eng.

491

400

View full text Add to dashboard Cite

show abstract

“…Biotrue (Bausch and Lomb Incorporated, Rochester, NY) (FDA 510(k) Summary K083757, ) is a sterile, isotonic solution containing high molecular weight (HMW) hyaluronic acid (HA) (MW = 1.4 MDa; concentration 0.01%, wt/wt),(Liu, Harmon, Maziarz, Rah, & Merchea, ) sulfobetaine zwitterionic detergent (<0.1%) and Tetronic 1107 (<5%) surfactant, boric acid (<1%), sodium borate (<1%), edetate disodium (<1%), sodium chloride (<1%), and a dual disinfection system of polyaminopropyl biguanide (0.00013%, wt/wt) and polyquaternium‐1 (0.0001%) (Liu et al, ; Reindel, Cairns, & Merchea, ) OPTI‐FREE EXPRESS (Alcon Laboratories, Inc., Ft. Worth, TX) is a sterile, isotonic solution containing sorbitol detergent, Tetronic 1304 surfactant, sodium citrate, sodium chloride, boric acid, aminomethylpropanol 95, disodium EDTA, and a dual disinfection system of polyquaternium‐1 (0.001%) and myristamidopropyl dimethylamine (0.0005%) (FDA 510(k) Summary K021143, ). OPTI‐FREE Puremoist (Alcon Laboratories) is a sterile, isotonic solution containing sorbitol detergent, Tetronic 1304 and ethylene oxide—butylene oxide block co‐polymer (EOBO‐41) surfactants, sodium citrate, sodium chloride, boric acid, aminomethylpropanol 95, disodium EDTA, and a dual disinfection system of polyquaternium‐1 (0.001%) and myristamidopropyl dimethylamine (0.0006%) (FDA 510(k) Summary K102860, ).…”

Section: Methodsmentioning

confidence: 99%

Effect of multipurpose care solutions upon physical dimensions of silicone hydrogel contact lenses

et al. 2019

View full text Add to dashboard Cite

Interactions between contact lens multipurpose solution (MPS) components and the contact lenses with which they are used are both lens and solution dependent. As such, lens dimensional changes may arise after cleaning and immersion cycling in different lens care solutions over different time courses. In this study, the dimensional stability of five planned-replacement silicone hydrogel lenses (lotrafilcon B, comfilcon A, senofilcon A, senofilcon C, and samfilcon A) over 30 cycles in three different MPSs (Biotrue, OPTI-FREE Express, and OPTI-FREE Puremoist) was evaluated. Measurements of diameter, sagittal depth, power, roundness, and center thickness were obtained prior to, during, and after 30 cycles of cleaning and storage. Diameters of all lenses increased when soaked in Express or Biotrue but held the International Standards Organization (ISO) tolerance over the full course of 30 disinfection cycles; however, the diameters of comfilcon A, senofilcon A, senofilcon C, and samfilcon A lenses soaked in Puremoist exceeded ISO tolerance after between 4 and 9 immersion cycles. In contrast, the diameter of lotrafilcon B held tolerance. Similarly, all lenses cycled in Express or Biotrue held tolerance for sagittal depth, while in Puremoist only lotrafilcon B held tolerance. All lenses became less round in all MPSs but held tolerance for both power and central thickness. Given the lack of reported clinical issues with Puremoist when used with lenses other than lotrafilcon B, we propose that it may be appropriate to revisit the ISO test methods and tolerances to determine if they are still applicable for silicone hydrogel lenses. K E Y W O R D S ISO, lens care, lens-solution compatibility, multipurpose solution (MPS)

show abstract

“…The BBS-HA, BBS-P, and BBS-HA-P solutions contained 0.01% wt/vol HA, 0.2% wt/vol P and 0.01% wt/vol HA + 0.2% wt/vol P, respectively. Finally, the commercial multi-purpose solution Biotrue ® from Bausch + Lomb (pH = 7.50 ± 0.02 and osmolarity equal to 285 ± 1.0 mOsm/L) [21,22] was also evaluated.…”

Section: Materials and Solutionsmentioning

confidence: 99%

Terahertz-based system for dehydration analysis of hydrogel contact lenses

et al. 2019

View full text Add to dashboard Cite

The use of terahertz-based techniques has grown very fast since they are capable of performing evaluations at molecular level, being very suitable for the analysis of biological samples and biomaterials such as those for contact lenses. These biomaterials are continuously evolving to enhance the lens wearer's comfort by improving their hydration state and surface wettability. Therefore, this study examines a novel terahertz system for the assessment of the temporary in vitro dehydration of hydrogel contact lenses, which provides a new index to assess their state of hydration. Several conventional and silicone hydrogel contact lenses and lens care solutions were analysed. Traditional methods such as the gravimetric determination of water content and the measurement of the static contact angle were also carried out for the validation of the developed system. The dehydration rate measurements of contact lenses obtained with the proposed system correlated with the values provided by traditional methods. As a whole, conventional hydrogel contact lenses exhibited the lowest values for dehydration rate. The tests conducted on various solutions showed a correlation between the wetting action of the solution and the dehydration rate of the contact lens material.

show abstract

Comparative Studies of Hyaluronan in Marketed Ophthalmic Products

Cited by 13 publications

References 17 publications

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Effect of multipurpose care solutions upon physical dimensions of silicone hydrogel contact lenses

Terahertz-based system for dehydration analysis of hydrogel contact lenses

Contact Info

Product

Resources

About