Comparative Studies of Photophysicochemical Properties of Non-Peripherally Anisole/Thioanisole-Tetrasubstituted Gallium (III) Phthalocyanines Containing Oxygen/ Sulfur Bridge

Günsel, Armağan

doi:10.18596/jotcsa.357551

Journal of the Turkish Chemical Society, Section A: Chemistry

2017

DOI: 10.18596/jotcsa.357551

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Comparative Studies of Photophysicochemical Properties of Non-Peripherally Anisole/Thioanisole-Tetrasubstituted Gallium (III) Phthalocyanines Containing Oxygen/ Sulfur Bridge

Armağan Günsel

Abstract: Abstract:In this work, we have presented the synthesis and characterization of gallium(III) phthalocyanines (4-6) which are non-peripherally tetra-substituted with anisole or thioanisole functional groups containing oxygen or sulfur bridge. Confirmation of the phthalocyanine structures performed with the cooperation of elemental analysis, FTIR, 1 H-NMR, UV-Vis and MALDI-MS spectral data. Also, we have investigated and discussed the effects of nonperipherally tetra-substitution with different functional groups … Show more

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Cited by 3 publications

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Optical characterizations of synthetic nano PcGaCl thin film. In vitro, hemocompatibility, cytotoxicity, and PDT valuation

Al-Qaissi¹,

Al-qarni²,

Al-Aniezi³

et al. 2022

DJNB

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Doped Phthalocyanines compounds are very applicable materials that have been utilized in different fields of industry and medicine such as photovoltaic, fuel cell, and photodynamic therapy. Here, we report the optical, cytotoxicity, and PDT evaluation of PcGaCl thin film. The optical studies show that the investigated thin film has a high light abortion at a wavelength of 500 nm. the energy gap of PcGaCl thin film has been evaluated using the WDD model and it was found to be 3.9 eV. The hemocompatibility and cytotoxicity studies of PcGaCl thin film have been evaluated in Caco-2, melanoma, and fibroblast. PcGaCl thin film showed no cytotoxicity in the dark. Upon exposure to different radiation doses of 2.5 J/cm2, 4.5 J/cm2, and 8.5 J/cm2, PcGaCl thin film has exhibited a high photocytotoxicity. The result suggests that Ga(III)Cl thin film can be considered a promising photosensitizer for Photodynamic therapy (PDT).

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Optical characterizations of synthetic nano PcGaCl thin film. In vitro, hemocompatibility, cytotoxicity, and PDT valuation

Al-Qaissi¹,

Al-qarni²,

Al-Aniezi³

et al. 2022

DJNB

View full text Add to dashboard Cite

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Ferulic Acid Substituted Zn(II) Phthalocyanine: Synthesis, Characterization and Investigation of Photophysical and Photochemical Properties

Gördük

2018

Journal of the Turkish Chemical Society Section A: Chemistry

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In this study, novel peripherally ferulic acid tetra-substituted Zn(II) phthalocyanine was synthesized for the first time. The synthesized phthalocyanine was characterized by elemental analysis, infrared spectroscopy, UV-Vis spectrophotometry, 1 H-NMR spectroscopy, and MALDI-TOF MS techniques. The photophysical, photochemical and aggregation properties of this phthalocyanine were also investigated in DMSO and DMF solvents. The aggregation studies showed that the synthesized Zn(II) phthalocyanine does not aggregate in DMSO and DMF. Fluorescence quantum yield (ΦF: 0.23 in DMSO and 0.17 in DMF), singlet oxygen quantum yield (Φ∆:0.57 in DMSO and 0.45 in DMF) and photodegradation quantum yield (Φd:1.08x10 -5 in DMSO and 4.44x10 -5 in DMF) were also determined. These results show that the synthesized phthalocyanine has potential use in photodynamic therapy.

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Investigation of singlet oxygen production property of peripherally tetra-substituted In(III)CI phthalocyanine for photodynamic therapy

Gördük

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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Phthalocyanines (Pcs) are macrocyclic compounds of great importance. Different metals and ligands can be used in the synthesis of Pc compounds and they give different properties to Pcs. Thus, the applications of Pcs have been increasing every day. One of the most important areas of use of Pcs is photodynamic therapy (PDT) application. The scope of this study is synthesis, characterization, and investigation of singlet oxygen generation property of new peripherally tetrakis(benzodioxane) substituted indium(III) chloride phthalocyanine (InCIPc). The compound may be used as a potential photosensitizer for PDT applications. The new compound was characterized by various techniques such as elemental analysis, FT-IR, 1 H NMR, MS, and UV-Vis techniques. Furthermore, photophysical and photochemical properties of the synthesized Pc were investigated for PDT studies. At the same time, the effect of combination of heavy indium atom and benzodioxane groups bearing oxygen atom on solubility and photophysicochemical properties was discussed. The results showed that this compound exhibits good solubility in DMSO and shows high singlet oxygen production (ΦΔ: 0.76). According to the displayed properties and singlet oxygen production, we can say that this compound is a potential candidate for PDT applications.

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Comparative Studies of Photophysicochemical Properties of Non-Peripherally Anisole/Thioanisole-Tetrasubstituted Gallium (III) Phthalocyanines Containing Oxygen/ Sulfur Bridge

Cited by 3 publications

References 29 publications

Optical characterizations of synthetic nano PcGaCl thin film. In vitro, hemocompatibility, cytotoxicity, and PDT valuation

Optical characterizations of synthetic nano PcGaCl thin film. In vitro, hemocompatibility, cytotoxicity, and PDT valuation

Ferulic Acid Substituted Zn(II) Phthalocyanine: Synthesis, Characterization and Investigation of Photophysical and Photochemical Properties

Investigation of singlet oxygen production property of peripherally tetra-substituted In(III)CI phthalocyanine for photodynamic therapy

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