Comparative studies of phytochemical analysis and pharmacological activities of wild and micropropagated plant ethanol extracts of Manihot esculenta

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“…However, it occurs in most natural sources and is responsible for their medicinal uses. Earlier studies reported that n-hexadecanoic acid has antiinflammatory, antioxidant, anti-androgenic, and hypocholesterolemic activities 20 . n-hexadecanoic acid suppresses the inflammatory process by its inhibitory action of phospholipase A2 enzyme 23 .…”

“…Tetradecanoic acid, a saturated fatty acid (myristic acid) that was identified in the extract, has antioxidant, anti-cancer activity, and hypocholesterolemic activities 20 . Whereas a ketone compound, 2-pentadecanone 6, 10, 14-trimethylwith anti-inflammatory, wound healing, and antibacterial activity 21 was also identified with 0.92% peak area in this extract (CICME).…”

“…A phthalic ester compound, 1, 2-benzene dicarboxylic acid, mono (2-ethylhexyl) ester has previously been reported with anti-cancer and cytotoxic activities 34 . Some of the compounds identified in the extract such as 1-methyl-pyrrolidine-2-carboxylic acid 17 , Octadecanoic acid 32 , 9-Octadecanoic acid, (Z)methyl ester, have been reported to have antifungal and antibacterial activities 20,35 .…”

“…Linolenic compounds such as n-hexadecanoic acid (27.65%), 9, 12-Octa-decadienoic acid, (Z, Z) -(5.34%), 9, 12, 15-Octadecatrieonic acid,(Z, Z, Z)-( 19.75%) and Octadecanoic acid (4.77%) are more common in several medicinal plants. However, these secondary metabolites are responsible for their pharmacological actions such as anti-inflammatory, antioxidant, and anti-cancer activities 20,22,38 . Additionally, octadecanoic acid has antibacterial and antifungal activities 32 .…”

Box-Behnken experimental design for extraction optimization of cytotoxic activity from Curcuma aeruginosa rhizome

“…Previous works have founded the presence of various metabolites such as germacrene, camphor (Akarchariya et al, 2017), curcuminoid (Nurcholis et al, 016a, 2019), cycloisolongifolene, 8,9-dihydro formyl, dihydrocostunolide (Kamazeri et al, 2012), terpenoids (Simoh and Zainal, 2015), and sesquiterpenes (Takano et al, 1995;Suphrom et al, 2012;Awin et al, 2019) in the C. aeruginosa extract. Several reports have reported that the metabolites content in medicinal plant extract associated with the pharmacological activities (Mosbah et al, 2018;Chinnadurai et al, 2019;Bistgani and Se idkon, 2019). Thus, the development of rhizome extraction is needed to produce rhizome extract from C. aeruginosa with high pharmacological properties.…”