Comparative Studies of Serum Polysaccharides in Rheumatoid Arthritis and Degenerative Joint Disease

Objective Evaluation of Patients with Rheumatic Diseases. II. Paper Electrophoretic Studies of Serum Glycoprotein and Protein from Patients with Rheumatoid Arthritis1

“…Only slight changes of albumin carbohydrate percentage occurred in patients with rheumatoid arthritis. This is in contrast to data obtained by salt fractionation methods as previously reported (11) in which striking increases of albumin bound carbohydrate were found in active rheumatoid arthritis. The most likely explanation of the disparity between the data obtained by the two methods is that the albumin fraction obtained by salt fractionation contains appreciable amounts of carbohydrate rich globulin, and thus has a higher carbohydrate content.…”

Content and Composition of the Mucoprotein Fraction of Human Serum (Seromucoid) in Disease, With Special Reference to Hematologic Disorders1

“…Thus, its constituents are usually recovered from the a1-, a2-, and ft-fractions; in pathologic conditions they may be recovered from the y-fraction. Other supportive evidence can be obtained from the literature which suggests the largest amount of protein-bound hexoses to be found with the a-globulins in most disease states (13)(14)(15). In carcinoma and in rheumatic fever, however, protein-bound hexoses are most abundant in the albumin fraction (16,17).…”

“…were separated as described by . This method is based on the precipita- (21,22,16), sarcoidosis and cancer (22,16), rheumatic fever in relapse (9), rheumatoid arthritis (15), diabetes mellitus with complications (14), disseminated malignancies (23,24), leukemia, lymphoma, chronic infections, colitis, acute glomerulonephritis, prostatic hypertrophy (24). Elevated in carcinoma, benign tumors, arthritis, bacterial infections (17), disseminated malignancies (25,26), tuberculosis (27,28).…”

“…Decreased in liver disease, some endocrine dysfunctions, nephrosis (12). Elevated in rheumatoid arthritis (15 Tables II and III show that dilution and molarity of perchloric acid were of relatively little bearing on the final yield of mucoproteins. Thus, a molarity of 0.24 M was used in the course of this study, a figure which seemed to assure the complete precipitation of the total protein fraction with a minimum amount of reagent.…”

Serum Mucoprotein

“…As a result, it seems to have stronger relation to atheromatous changes than abnormal metabolism, however, further study must be preformed to make definite com ment about this point. Sinkin et al (25) and Shetlar et al (26) reported that in coronary infarction, correlation between serum mucoprotein level and changes in myocardium was stronger than correlation between changes in myocardium and erythrocyte sedi mentation rate or leucocyte count. In present study, there was strong correlation between serum mucoprotein levels and cardiac involvement, not only just after the myocardial infarction, but in cases of which electrocardiogram revealed myocardial damage.…”