Comparative Studies of the Aqueous and Ethanolic Extracts of Ocimum gratissimum and Gongronema latifolium Leaves on the invivo Antioxidant levels of Wistar Albino Rats

Nwaka, Andrew C.

doi:10.25240/tjans.2017.2.1.09

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…The oral median lethal doses (LD50) of N. laevis stem-bark extract were estimated to be greater than 5000 mg/kg suggesting that the extract was relatively safe and non-toxic. 19 This result is consistent with the report of [27][28] who reported that no mortality was recorded up to 5000 mg/kg in the root and ethanol leaf extracts of N. laevis and the estimated LD50 was greater than 5000 mg/kg. For the 28 days treatment, an obvious increase in weight was seen as from week 2 at which the group that received the highest dose (1,000 mg/kg) showed significant (p ≤ 0.05) increase in weight compared to all other groups, but subsequently in weeks 3 and 4, significant (p ≤ 0.05) and dose dependent weight increase was observed at all doses administered (Figure 1).…”

Section: Resultssupporting

confidence: 91%

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

2023

TJNPR

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This research aimed at evaluating the toxicological profile of ethanol stem-bark extract of N. laevis in Wistar rats. Repeated oral dose toxicity studies (28 and 90 days) were carried out with 32 rats for 28-day study and 40 rats for 90-day study. The rats were divided into 4 groups (A, B, C and D) of six rats per group and were treated with 250, 500 and 1,000 mg/kg body-weight of the extract for 28 and 90 days respectively. Blood samples were collected at the end of the experiment and were used for Biochemical and Haematological investigations, organs were also collected for histological examination. There was significant (p ≤ 0.05) reduction in WBCs following 28-day treatment and a significant (p ≤ 0.05) increase after 90-day treatment. The RBCs, haemoglobin and haematocrit increased significantly (p ≤ 0.05) at 1,000 mg/kg following 28-day treatment and at all doses for RBCs and haemoglobin after 90-day treatment. A significant (p ≤ 0.05) increase in HDL and a decrease in LDL was observed after 28-day treatment, the 90 days treatment showed significant (p ≤ 0.05) decrease in HDL and an increase in LDL. The AST level also increased significantly (p ≤ 0.05) after 28-day treatment. Histological-examination revealed pathological abnormalities in kidney and liver of the treated rats at all doses. This study showed that extract of N. laevis stem-bark was toxic when used at high doses and for a long period of time in the treated rats.

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Section: Resultssupporting

confidence: 91%

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

2023

TJNPR

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“…The ethanol extract of C. odorata showed a significant decrease in bleeding and clotting times. The results indicated that the leaves of C. odorata had a potent hemostatic properties [41].…”

Section: Hemostatic Propertiesmentioning

confidence: 97%

Standardization of Chromolaena Odorata, Kaempferia Parviflora and Zanthoxylum Piperitum

Pitakpawasutthi

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Chromolaena odorata (L.) R.M. King & H. Rob. or Sabsue is a species in family Asteraceae. In Thailand, it is locally used to treat skin diseases, diabetes, as well as insect bites. Kaempferia parviflora Wall. ex Baker or Krachai Dum belongs to Zingiberaceae family. In herbal medicine, it is generally used to promote health, to cure gastrointestinal disorder and anti-inflammation. Zanthoxylum piperitum (L.) DC., belonging to the Rutaceae family, is known in Thai name as Prig Horm. All parts of Z. piperitum are used to treat abdominal pain, vomiting and diarrhea. Chlorogenic acid, 5,7-dimethoxyflavone and xanthoxylin are the active components in C. odorata leaves, K. parviflora rhizomes and Z. piperitum fruits respectively and these compounds were used as a standard marker in this study. For quantitative analysis, the results indicated that the chlorogenic acid, 5,7-dimethoxyflavone and xanthoxylin contents quantified by TLC-densitometry and TLC image analysis were not statistically significantly different (P > 0.05). For in vitro biological activities, the results revealed that each extract and its active constituents showed its antioxidant and anti-diabetic potentials. K. parviflora rhizome showed potent toxicity whilst C. odorata leaf and Z. piperitum fruit ethanolic extract showed weak toxicity against brine shrimp nauplii. As the result of cell viability activity, all tested samples exhibited no significant cytotoxic activity against 5 human cancer and 1 normal cell lines. For GC-MS analysis, each plant samples showed its major components of essential oil. Furthermore, the pharmacognostic specification of K. parviflora rhizomes were established in order to provide macroscopic and microscopic evaluation, physico-chemical parameters and chemical fingerprints.

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Comparative Studies of the Aqueous and Ethanolic Extracts of Ocimum gratissimum and Gongronema latifolium Leaves on the invivo Antioxidant levels of Wistar Albino Rats

Cited by 2 publications

References 9 publications

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

Studies on the Toxicological Properties of Ethanol Stem-Bark Extract of Newbouldia laevis (P. Beauv) Seem in Rats

Standardization of Chromolaena Odorata, Kaempferia Parviflora and Zanthoxylum Piperitum

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