Comparative Studies on Autoplastic Lymph Node and Thymus Transplants.

Marmorston-Gottesman, J.; Gottesman, J.

doi:10.3181/00379727-25-3914

Cited by 4 publications

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“…In agreement with the findings of other authors [Marmorston-Gottesman & Gottesman, 1928;Ingle, 1937;Wyman & TumSuden, 1937] the present investigation has also shown that adrenalectomy causes a considerable increase in the toxicity of histamine for the rat, the LD 50 found being substantially similar to that found by Komrad & Wyman [ 1951 ] if the molecular weight of the different histamine compounds used be taken into account. The LD 50 for rats enucleated for 2 months is twenty-two times greater than that for adrenalectomized animals and is about one-half the value for normal animals.…”

Section: Discussionsupporting

confidence: 94%

“…The results of the present investigation confirm that the normal rat shows a high resistance to histamine [Crivellari, 1927;Marmorston-Gottesman & Gottesman, 1928;Feldberg & Schilf, 1930], slightly less than that of the mouse [Halpern & Wood, 1950], but higher than that ofthe pigeon, guinea-pig, rabbit, dog, cat and monkey [Feldberg & Schilf, 1930;Bovet & Bovet-Nitti, 1948]. In agreement with the findings of other authors [Marmorston-Gottesman & Gottesman, 1928;Ingle, 1937;Wyman & TumSuden, 1937] the present investigation has also shown that adrenalectomy causes a considerable increase in the toxicity of histamine for the rat, the LD 50 found being substantially similar to that found by Komrad & Wyman [ 1951 ] if the molecular weight of the different histamine compounds used be taken into account.…”

Section: Discussionsupporting

confidence: 89%

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Role of the Adrenal Cortex Regenerated After Enucleation in the Resistance Against Histamine Shock

Brogi¹

1956

Journal of Endocrinology

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1. The resistance of rats to the injection of histamine has been studied quantitatively by determining the LD 50 for this substance in normal and adrenalectomized rats, and in rats whose adrenals had been enucleated 2 months previously.2. The LD50 for adrenalectomized rats is about one-fiftieth, and for enucleated rats greater than one-third of that for normal animals. The LD50 for adrenalectomized rats injected with 100 \g=m\g of adrenaline was similar to that of enucleated rats.3. The administration of 100\g=m\g of adrenaline to enucleated animals significantly increased their resistance to histamine, but did not bring it back to normal values; the difference between enucleated and normal rats thus appeared to be related, in part, at least, to the absence of the medullary secretion; no data are available to account for the rest of the difference.An earlier study of the resistance of rats with enucleated adrenals to intraperitoneal injections of hypertonic glucose solution [Brogi, 1954a] has shown that 13 days after enucleation, the resistance of the animals to this form of stress, markedly lowered as a consequence of the operation, is fully re-established. Together with the observations of Pellegrino (personal communication) on the resistance of enucleated rats to phloridzin diabetes and to fasting, these data show that 15 days after enucleation a normal resistance to some forms of noxious stimulus is re-established. On the other hand, according to Houssay [1952], enucleated adrenals are relatively little able to protect animals against the effects of histamine, the lethal dose of this substance in rats enucleated for an unstated length of time (presumably at least 1 month) being onetenth of that which kills normal animals.Since, therefore, the protective ability of the enucleated adrenal does not seem to apply equally to all noxious stimuli, it was thought worth while (i) to study the phenomenon observed by Houssay [1952] more accurately and from a quantitative point of view, and (ii) to investigate the relationship of this phenomenon to the absence of the adrenal medulla which is characteristic of the enucleated gland. MATERIALS AND METHODS AnimalsTwo hundred and forty female albino rats of the Italico strain were divided into the following five groups: group 1, normal, unoperated; group 2, adrenalectomized; group 3, adrenalectomized and subsequently given adrenaline; group 4, subjected to adrenal enucleation [Hartman, Brownell & Knouff, 1947]; group 5, enucleated and subsequently given adrenaline. All operations were performed under light ether anaesthesia.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 89%

Role of the Adrenal Cortex Regenerated After Enucleation in the Resistance Against Histamine Shock

Brogi¹

1956

Journal of Endocrinology

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“…About 65 years ago the first experiments on transplanting lymph node fragments into pockets of the abdominal muscles were published (Jaffe and Richter, 1928;Marmorston-Gottesman and Gottesman, 1928). Initially nearly all cells underwent necrosis, but some reticular cells appeared to survive at the outer border, as in the present study.…”

Section: Discussionsupporting

confidence: 72%

Development of the high endothelial venule in rat lymph node autografts

1994

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Vascular reconstruction during rat lymph node regeneration was investigated in autotransplanted mesenteric lymph node fragments, which had been implanted in the renal parenchyma. In addition to light microscopy, vascular casting and transmission electron microscopy were used. From day 3 onwards capillaries grew into the autografts together with lymphatic vessels. The capillaries showed obvious signs of proliferation by day 5. The surviving interstitial cells at the outer border of the transplant produced extracellular substance. High endothelial venules (HEV) differentiated from capillaries from about day 7. A first sign of their development was a vessel with a narrow, branching luminal space and with endothelial cells containing rich cytoplasm and small Golgi complexes. As the Golgi complexes grew and the cisternae and vesicles increased, the lumen dilated, the cell coat on the luminal surface became prominent, and, finally, lymphocytes emigrated through these venules from around day 10. The typical lymph node structure was complete by day 28. These results suggest that the interaction among the remaining interstitial cells, invading capillaries, and lymphatic penetration results in differentiation and maturation of HEV in lymph node regeneration. The development of Golgi complexes is strongly associated with lymphocyte emigration from the blood.

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Die Thymektomie und ihr Erscheinungsbild

Bomskov¹,

Hölscher²

1942

Pflügers Arch.

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Comparative Studies on Autoplastic Lymph Node and Thymus Transplants.

Cited by 4 publications

References 0 publications

Role of the Adrenal Cortex Regenerated After Enucleation in the Resistance Against Histamine Shock

Role of the Adrenal Cortex Regenerated After Enucleation in the Resistance Against Histamine Shock

Development of the high endothelial venule in rat lymph node autografts

Die Thymektomie und ihr Erscheinungsbild

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