Comparative Studies on the Effect of Vitamin A, B₁ and B₆Deficiency on Oxalate Metabolism in Male Rats

Abstract

The study was conducted to investigate the effect of vitamin A, B₁ and B₆ deficiency on oxalate metabolism in rats. A significant hyperoxaluria was the common observation in all the three vitamin deficiencies (vitamin B₆> vitamin A > vitamin B₁). The activities of hepatic glycolate oxidase and glycolate dehydrogenase were markedly enhanced in vitamin-A- and vitamin-B₆-deficient rats. However, lactate dehydrogenase levels remained unaltered in these deficiencies as compared to their respective pair-fed controls. Vitamin B₁ deficiency of 4 weeks’ duration could augment the activity of glycolate oxidase only, with no alterations in the glycolate dehydrogenase and lactate dehydrogenase levels. Intestinal oxalate uptake studies revealed increased bio-availability of oxalate from the gut in vitamin-A- and vitamin-B₆-deficient rats. Thus, the results suggest the relative contribution of both exogenous as well as endogenous oxalate in the process of calculogenesis under various nutritional stress conditions in rat.

The efficacy of antioxidant therapy against oxidative stress and androgen rise in ethylene glycol induced nephrolithiasis in Wistar rats

“…A and Vit. B6-deficient rats, 34 and pyridoxine is known to be an effective first-line therapy to decrease hyperoxaluria in patients who develop stones. 16 Ascorbic acid, as well as other radical scavengers, and the antioxidant enzymes decreased in urolithic condition, suggestive of the active involvement of free radical-mediated lipid peroxidation-induced membrane damage in kidney.…”

Antidotes for toxicological emergencies: A practical review

“…thiamine hydrochloride 100 mg and i.v. pyridoxine hydrochloride 50 mg every six hours should shunt the metabolism of ethylene glycol away from production of oxalic acid to production of less toxic metabolites 26,27 ; though there are no data from studies of humans to support this practice, these agents are well tolerated and the potential benefits outweigh any risks.…”

Influence of Multivitamin Regimen on Urinary Oxalate in Home Parenteral Nutrition Patients

“…Hyperoxaluria has been noted in the presence of thiamin and pyridoxine deficiencies. 28,29 This would be an unlikely cause because the HPN patients were provided with adequate dosages of these vitamins. 18,30 Serum levels were not measured, but the patients did not exhibit any clinical signs of thiamin or pyridoxine deficiency.…”