Comparative Study Between Silver Nanoparticles Dressing (SilvrSTAT Gel) and Conventional Dressing in Diabetic Foot Ulcer Healing: A Prospective Randomized Study

Abstract

Background We are trying to evaluate silver nanoparticles’ effectiveness (SilvrSTAT Gel) in accelerating healing rate of nonischemic diabetic foot ulcers (DFUs). Methods This prospective, double-blind, randomized, controlled study includes 80 patients with nonischemic DFUs classified into 2 groups. Group A was subjected to SilvrSTAT Gel dressing, and group B was subjected to conventional dressing (wet-to-moist dressing with or without povidone-iodine). All cases had minimal debridement before treatment. In both groups, all cases were nonischemic after successful revascularization either by bypass surgery or endovascular therapy. Results The healing rate of the SilvrSTAT group was significantly higher than that of the conventional group. The healing rate per week of the SilvrSTAT group was considerably higher than that of the conventional group ( P < .0001). The rate of complete healing for ulcers in group A was achieved in 22 patients (55%) by the 6th week, while 29 (72.5%), 34 (85%), and 36 (90%) patients were healed entirely by the 8th, 10th, and 12th weeks, respectively. In group B: 20 (50%), 27 (67.5%), and 30 (75%) patients were completeley healed by the 8th, 10th, and 12th weeks, respectively. Conclusions SilvrSTATGel is effective in the treatment of DFU.

Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Composite Nanosilver (AgNPs) - Based Dressing Vs. Traditional Dressing: A Prospective Randomized Control Study

“…After the implementation of the hydrogel/nano silverbased dressing on patient's with DFU of the present study, the findings illustrated that use of hydrogel\nano silver wound dressing compared to the traditional dressing showed a more significant reduction in the area when the initial wound area is compared to the subsequent area measurements expressed as the initial percentage. The wound healing is in agreement with Essa et al 2021, who have recently compared silver Nanoparticles dressing and conventional dressing in diabetic foot healing, and their findings proved that the healing rate was statistically significant and the healing rate per week and the complete recovery was achieved with SliverSTAT group, around onefifth of the study sample by six weeks where the rest of the patients were healed from week eight to week twelve, whereas the conventional group the wound healing started from week eight to week twelve (31) .…”

Cost-Effectiveness of Nano Silver Compounds as a Single Dressing in Wound Healing

“…On the other hand, Wounds were healed spontaneously in 14 patients (70%) in group B patients and skin graft was successfully taken in 4 patients 20%. Essa reported that: After the implementation of the hydrogel/ nano silver-based dressing on patients with chronic leg ulcer of the present study, the findings illustrated that use of hydrogel\nano silver wound dressing compared to the traditional dressing showed a more significant reduction in the area when the initial wound area is compared to the subsequent area measurements expressed as the initial percentage and their findings proved that the healing rate was statistically significant and the healing rate per week and the complete recovery was achieved with Sliver STAT group, around one-fifth of the study sample by six weeks where the rest of the patients were healed from week eight to week twelve, whereas the conventional group the wound healing started from week eight to week twelve [12].…”

Nanocomposites used in the treatment of skin lesions: a scoping review

“…Healing in diabetic foot ulcers has been described at around 95.8% ( 26 ) , 85% ( 33 ) , 81.8% ( 27 ) , 71% ( 28 ) and a reduction of ±7 cm ( 18 ) , pressure sores at 16.4% ( 29 ) and a reduction of ±15 cm ( 20 ) ; leg ulcers a reduction of ±5 cm ( 19 ) and a reduction of 43 days in treatment time ( 35 ) ; venous ulcers healing was 92.8% ( 22 ) , 86.4% ( 30 ) ; surgical wounds healing was 93% ( 31 ) and burns 90.7% ( 24 ) .…”

“…The technological advance inherent in the development of nanotechnology strengthens and disseminates in the academic field technological possibilities for resolving preponderant issues in the field of health ( 37 ) . The manufacture of nanocomposites for the health care of patients with skin lesions is being explored with this nanotechnological development, resulting in the supply of synthetic dressings with silver nanoparticles ( 21 , 24 , 32 , 36 ) , biomaterials with nanocrystalline silver ( 27 , 34 ) , nanofibers loaded with bioactive substances ( 16 , 18 , 19 , 30 , 35 ) , nanofibers loaded with growth factors ( 17 , 28 ) or even synthetic dressings with growth factors ( 25 ) , hydrogels with growth factors ( 26 ) , nanogels ( 23 , 33 ) , nanoemulsions ( 31 ) and the possibility of associating adjuvant therapies with nanocomposites ( 22 , 29 ) .…”