Comparative study between topical tranexamic acid alone versus its combination with autologous platelet rich plasma for treatment of melasma

Gamea, Mohamed M; Kamal, Doha Ali; Donia, Ahmed A.; Hegab, Doaa Salah

doi:10.1080/09546634.2020.1781755

Cited by 28 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Difference in the reduction of mMASI was statistically significant in both the groups. They concluded that PRP may be used to boost the therapeutic effect of TA 21 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Autologous intralesional platelet rich plasma improves melasma

Tuknayat

Thami

Bhalla

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

Platelet rich plasma (PRP) is an upcoming interventional therapy for the treatment of melasma. Its efficacy is due to the multiple growth factors present in it which decrease melanogenesis by various signal transduction pathways. The present study evaluated the efficacy of PRP as a standalone agent in treatment of melasma. This is an open labeled prospective trial. Forty patients were given intralesional PRP at once monthly interval. Three such PRP sessions were carried out and the patients were followed up for 3 months. Assessment was done by calculating the modified melasma area severity index score (mMASI) for each patient. Patients were also asked to selfevaluate their improvement based on a scale. There was an average 54.5% reduction in the mMASI score at the end of the study. There was no relapse in any patient. This reduction was irrespective of the skin type, gender, and type of melasma. Patients self-evaluation showed that more than 90% of the patients were pleased or very pleased with the results. There were no significant side effects. PRP appears to be a potential new therapy with significant efficacy in improving pigmentation of melasma, standalone as monotherapy.

show abstract

“…Difference in the reduction of mMASI was statistically significant in both the groups. They concluded that PRP may be used to boost the therapeutic effect of TA 21 …”

Section: Discussionmentioning

confidence: 99%

“…They concluded that PRP may be used to boost the therapeutic effect of TA. 21 F I G U R E 1 A,B, Patient 1 preoperative and 6 months postoperative…”

Section: Yew Et Al Treated Two Cases Of Refractory Mixed Melasma Bymentioning

confidence: 99%

Autologous intralesional platelet rich plasma improves melasma

Tuknayat

Thami

Bhalla

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…A further four articles were excluded for the lack of essential information. Ultimately, ten studies were included in the data integration for MASI scores and subjective evaluation [19][20][21][22][23][24][25][26][27][28]. The inclusion and exclusion process of the studies is shown in Fig.…”

Section: Search Resultsmentioning

confidence: 99%

“…The year of publication ranged from 2018 to 2021. In terms of study design, there were four RCTs [19][20][21][22], three split-face trials [23,24,27] and three self-controlled trials [25,26,28]. Thelocations of these trials were China (3 trials), India (2 trials), Egypt (3 trials), Thailand (1 trial) and Pakistan (1 trial).…”

Section: Study Characteristicsmentioning

confidence: 99%

Efficacy and Safety of Platelet-Rich Plasma in Melasma: A Systematic Review and Meta-Analysis

Zhao

Xiao

et al. 2021

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Introduction: Melasma is a chronic and recurrent skin problem for which an effective therapy is currently lacking. Platelet-rich plasma (PRP) has recently emerged as a novel treatment for melasma, but to date there has been no systematic evaluation of its efficacy and safety. Methods: The Web of Science, PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and the Cochrane Library databases were searched for relevant articles using the search items ''melasma,'' ''chloasma'' and ''platelet-rich plasma.'' STATA version 15.1 software was used to analyze data. Study outcomes were calculated using standardized mean differences with 95% confidence intervals (CIs). Results: The database search identified ten studies involving 395 adult patients that met the inclusion criteria and were included in the meta-analysis. Analysis of pre-and post-treatment data from these studies revealed that the post-treatment modified Melasma Area and Severity Index (mMASI) score decreased by 1.18 (95% CI 0.89-1.47; p = 0.02). Subjective satisfaction evaluation of PRP treatment showed that melasma treated with the combination therapy of PRP ? microneedling may have been the most efficacious treatment compared to PRP alone or in combination with intradermal injection. Adverse reactions were minor, with only a few patients reporting local congestion, temporary erythema, hyperpigmentation and discoloration. Conclusion: These results support the efficacy and safety of PRP used in combination or alone as treatment for melasma.

show abstract

“…Platelets contain more than 30 growth factors such as platelet-derived growth factor (PDGF), transforming growth factor (TGF) beta 1 and 2, epidermal growth factor (EGF), platelet-derived angiogenesis factor, and fibrinogen. [48] ese growth factors play a role in various homeostatic mechanisms of the body.…”

Section: Platelet-rich Plasma (Prp) Therapymentioning

confidence: 99%

Tips for managing post-inflammatory hyperpigmentation of acne

Garg¹,

Tuknayat²

2021

CSDM

View full text Add to dashboard Cite

Post-inflammatory hyperpigmentation (PIH) is a reactive hypermelanosis, profoundly common in the Asian skin. The post-acne sequelae may have profound effects on the patients’ mental status, sometimes even more than the acne itself, as they are long lasting and sometimes treatment refractory. PIH occurs secondary to release of inflammatory mediators such as prostaglandins and interleukins in acne which stimulate melanogenesis. There are a multitude of therapeutic modalities available for the treatment of PIH associated with acne. Treating acne and PIH simultaneously would be a logical approach. Epidermal PIH usually responds to topical skin lightening agents which are the first line in these cases. Patients refractory to topical and oral treatment modalities usually have dermal PIH and may be offered interventional therapies. These therapies can be utilized simultaneously along with conventional therapies to hasten up the results, as combination treatment works synergistically by multipronged action at different pathways of etiopathogenesis. The patients with dermal PIH refractory to standard treatment may require other adjunctive therapies such as chemical peels, PRP, and lasers. This review provides an insight into rational and holistic approach to the management of the underlying acne, early customized treatment along with correction of underlying nutritional deficiencies, and lifestyle modifications in effective treatment of PIH.

show abstract

Comparative study between topical tranexamic acid alone versus its combination with autologous platelet rich plasma for treatment of melasma

Cited by 28 publications

References 30 publications

Autologous intralesional platelet rich plasma improves melasma

Autologous intralesional platelet rich plasma improves melasma

Efficacy and Safety of Platelet-Rich Plasma in Melasma: A Systematic Review and Meta-Analysis

Tips for managing post-inflammatory hyperpigmentation of acne

Contact Info

Product

Resources

About